IP Library › Patent Application 13423095
Patent Application
App. No. 13/423,095

COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERPLASIA

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
13/423,095
Abstract

In accordance with the present invention, there are provided methods for treating hyperplasia in a subject in need thereof. In another aspect of the invention, there are provided methods for reducing neointimal hyperplasia associated with vascular interventional procedures. Formulations contemplated for use herein comprise proteins and at least one pharmaceutically active agent.

Claims (21)

1 . A method for treating hyperplasia in a subject in need thereof, said method comprising administering to said subject an effective amount of a composition comprising drug and protein.

2 . A method according to claim 1 wherein said drug is in nanoparticle form and is dispersed in said protein.

3 . A method according to claim 1 wherein said hyperplasia occurs in blood vessel neointima.

4 . A method according to claim 1 wherein said effective amount falls in the range of about 0.01 mg/kg up to about 15 mg/kg for a human subject.

5 . A method according to claim 4 wherein said administration of said composition is repeated over a dosing cycle between 1 day and 6 months.

6 . A method according to claim 1 wherein said composition is administered systemically.

7 . A method according to claim 6 wherein administration is accomplished intra-arterially, intravenously, by inhalation, or orally.

8 . A method according to claim 1 wherein said composition is administered before, during or after the occurrence of said hyperplasia.

9 . A method for reducing neointimal hyperplasia associated with vascular interventional procedure(s) in a subject in need thereof, said method comprising administering to said subject an effective amount of a composition comprising at least one drug and protein.

10 . A method according to claim 9 wherein said procedure comprises angioplasty, stenting or atherectomy.

11 . A method according to claim 9 wherein said composition is administered before, during or after the vascular interventional procedure.

12 . A method according to claim 9 wherein said composition is administered at the time of the vascular interventional procedure.

13 . A method according to claim 9 wherein said effective amount falls in the range of about 0.01 mg/kg up to about 15 mg/kg for a human subject.

14 . A method according to claim 13 wherein said administration of said composition is repeated over a dosing cycle between 1 day and 6 months.

15 . A method according to claim 9 wherein said composition is administered systemically.

16 . A method according to claim 9 wherein said composition is administered by deployment of a stent containing said at least one drug coated thereon.

17 . (canceled)

18 . A composition for treatment of hyperplasia, said composition comprising at least one drug and protein.

19 . A composition according to claim 18 wherein said at least one drug is in nanoparticle form and is dispersed in said protein.

20 . A composition according to claim 18 wherein said hyperplasia occurs in blood vessel neointima.

21 - 30 . (canceled)