BIO-ABSORBABLE BRACHYTHERAPY STRANDS
Provided herein are bio-absorbable strands for use in brachytherapy. In an embodiment, a plurality of discrete hollow bio-absorbable segments spaced apart from one another and encapsulated using a bio-absorbable material to form an elongated member configured to be implantable in patient tissue using a hollow needle. Each hollow bio-absorbable segment has a length, an outer periphery and an inner channel. Radioactive material is within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment. Contrast material is within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment.
1 . A bio-absorbable strand for use in brachytherapy, comprising:
a plurality of discrete hollow bio-absorbable segments made from a first bio-absorbable polymer material spaced apart from one another and encapsulated using a second bio-absorbent polymer material to form an elongated member configured to be implantable in patient tissue using a hollow needle;
each hollow bio-absorbable segment having a length, an outer periphery and an inner channel;
a radioactive material within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment; and
a contrast material, which is different from said first bio-absorbent polymer material and said second bio-absorbent polymer material, within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment.
2 . The strand of claim 1 , wherein the plurality of hollow bio-absorbable segments are spaced apart from one another in accordance with a treatment plan such that a spacing between one pair of segments is different than a spacing between another pair of segments.
3 . The strand of claim 1 , wherein the lengths of the plurality of hollow bio-absorbable segments are in accordance with a treatment plan such that a said length of one said segment is different than a length of another said segment.
4 . The strand of claim 1 , wherein both the radioactive material and the contrast material are within at least a portion of the inner channel each hollow bio-absorbable segment.
5 . The strand of claim 1 , wherein both the radioactive material and the contrast material coat at least a portion of the outer periphery each hollow bio-absorbable segment.
6 . The strand of claim 1 , wherein the contrast material comprises a radiopaque material.
7 . The strand of claim 1 , wherein the plurality of hollow bio-absorbable segments are spaced apart from one another by a plurality of discrete spacers.
8 . The strand of claim 1 , wherein the encapsulated plurality of discrete hollow bio-absorbable segments are overmolded using the second bio-absorbable polymer material to form the elongated member.
9 . The strand of claim 1 , wherein the encapsulated plurality of discrete hollow bio-absorbable segments are inserted into a hollow tube of the second bio-absorbable polymer material to form the elongated member.
10 . The strand of claim 1 , wherein the encapsulated plurality of discrete hollow bio-absorbable segments are inserted between a pair of bio-absorbable half-shell members of the second bio-absorbable polymer material to form the elongated member.
11 . The strand of claim 1 , further comprising a hollow helical groove extending through at least a portion of the elongated member to improve ultrasound visibility of the elongated member.
12 . A bio-absorbable strand for use in brachytherapy, comprising:
a plurality of discrete hollow bio-absorbable segments made from a first bio-absorbent polymer material and spaced apart from one another and encapsulated using a second bio-absorbable polymer material to form an elongated member configured to be implantable in patient tissue using a hollow needle;
each hollow bio-absorbable segment having a length, an outer periphery and an inner channel;
a contrast material, which is different from said first bio-absorbent polymer material and said second bio-absorbable polymer material, within at least a portion of the inner channel of each hollow bio-absorbable segment; and
a radioactive material coating at least a portion of the outer periphery of each hollow bio-absorbable segment.
13 . The strand of claim 12 , wherein the plurality of hollow bio-absorbable segments, which have the contrast material within at least a portion of the inner channel and the radioactive material coating at least a portion of the outer periphery, are spaced apart from one another in accordance with a treatment plan such that a spacing between one pair of segments is different than a spacing between another pair of segments.
14 . The strand of claim 12 , wherein the lengths of the plurality of hollow bio-absorbable segments, which have the contrast material within at least a portion of the inner channel and the radioactive material coating at least a portion of the outer periphery, are in accordance with a treatment plan such that a said length of one said segment is different than a length of another said segment.
15 . The strand of claim 12 , wherein the contrast material comprises a radiopaque material.
16 . The strand of claim 12 , wherein the plurality of hollow bio-absorbable segments are spaced apart from one another by a plurality of discrete spacers.
17 . The strand of claim 12 , wherein the encapsulated plurality of discrete hollow bio-absorbable segments are overmolded using the second bio-absorbable polymer material to form the elongated member.
18 . The strand of claim 12 , wherein the encapsulated plurality of discrete hollow bio-absorbable segments are inserted into a hollow tube of the second bio-absorbable polymer material to form the elongated member.
19 . The strand of claim 12 , wherein the encapsulated plurality of discrete hollow bio-absorbable segments are inserted between a pair of bio-absorbable half-shell members of the second bio-absorbable polymer material to form the elongated member.
20 . The strand of claim 12 , wherein at least one of the outer periphery and the inner channel, of each of the hollow bio-absorbable segments, has a generally helical shape extending along at least a portion of its length to improve ultrasound visibility of each of the segments.
21 . The strand of claim 12 , further comprising a hollow helical groove extending through at least a portion of the elongated member to improve ultrasound visibility of the elongated member.
22 . A bio-absorbable strand for use in brachytherapy, comprising:
a plurality of discrete hollow bio-absorbable segments made from a first bio-absorbent polymer material spaced apart from one another and encapsulated using a second bio-absorbable polymer material to form an elongated member configured to be implantable in patient tissue using a hollow needle;
each hollow bio-absorbable segment having a length, an outer periphery and an inner channel;
a radioactive material within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment; and
a contrast material, which is different from said first bio-absorbent polymer material and said second bio-absorbent polymer material, within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment;
wherein the plurality of hollow bio-absorbable segments are spaced apart from one another in accordance with a treatment plan such that a spacing between one pair of segments is different than a spacing between another pair of segments.
23 . A bio-absorbable strand for use in brachytherapy, comprising:
a plurality of discrete bio-absorbable segments made from a first bio-absorbent polymer material spaced apart from one another and encapsulated using a second bio-absorbable polymer material to form an elongated member configured to be implantable in patient tissue using a hollow needle;
each bio-absorbable segment having a length;
a radioactive material associated with each bio-absorbable segment; and
a contrast material, which is different from said first bio-absorbent polymer material and said second bio-absorbent polymer material, and which is associated with each bio-absorbable segment;
wherein the plurality of bio-absorbable segments are spaced apart from one another in accordance with a treatment plan such that a spacing between one pair of segments is different than a spacing between another pair of segments.
24 . The bio-absorbent strand of claim 1 wherein the first bio-absorbable polymer material is the same as the second bio-absorbable polymer material.
25 . The bio-absorbent strand of claim 12 wherein the first bio-absorbable polymer material is the same as the second bio-absorbable polymer material.
26 . The bio-absorbent strand of claim 22 wherein the first bio-absorbable polymer material is the same as the second bio-absorbable polymer material.
27 . The bio-absorbent strand of claim 23 wherein the first bio-absorbable polymer material is the same as the second bio-absorbable polymer material.