Electrolyte and pH monitoring for fluid removal processes
Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.
1. A system comprising:
a blood fluid removal device comprising:
(i) an inlet for receiving blood from a patient,
(ii) an outlet for returning blood from the patient,
(iii) a medium for removing fluid and contaminants from the blood, the medium being positioned between the inlet and the outlet, and
(iv) a fluid source for carrying dialysate to the medium;
a concentrate source for housing a concentrate solution comprising concentrated electrolyte or pH buffer;
a concentrate flow control element for controlling the rate that the concentrate solution enters the fluid source;
a first sensor configured to monitor an indicator of blood electrolyte concentration or blood pH in the blood before the blood enters the medium,
a second sensor configured to monitor an indicator of blood electrolyte concentration or blood pH in the blood after the blood exits the medium and before a replacement fluid is added to the blood; and
control electronics in operable communication with the first sensor and the concentrate flow control element,
wherein the control electronics are configured, via the concentrate flow control element, to adjust the rate at which the concentrate solution enters the fluid source based on the rate of change of blood pH or blood electrolyte concentration based on data obtained from the first sensor and the second sensor.
2. The system of claim 1 , wherein the control electronics are in operable communication with the second sensor and are configured to compare data acquired from the first sensor to data acquired from the second sensor, and wherein the control electronics are configured to adjust the rate at which the concentrate solution enters the fluid source based on the comparison of the data acquired from the first sensor and the second sensor.
3. The system of claim 1 , wherein a third sensor is configured to monitor the indicator in fluid removed from the blood after the fluid removed from the blood exits the medium.
4. The system of claim 3 , wherein the control electronics are configured to derive the blood pH or blood electrolyte concentration based on data acquired from the third sensor.
5. The system of claim 3 , further comprising a fourth sensor configured to monitor the indicator in dialysate in the fluid source before the dialysate enters the medium, wherein the control electronics are in operable communication with the fourth sensor and are configured to compare data acquired from the third sensor to data acquired from the fourth sensor, and wherein the control electronics are configured to adjust the rate at which the concentrate solution enters the fluid source based on the comparison of the data acquired from the third sensor and the fourth sensor.
6. The system of claim 1 , further comprising a third sensor configured to monitor the indicator in the blood after the replacement fluid has been added to the blood.
7. The system of claim 1 , wherein the control electronics, or components thereof, are housed within a housing of the blood fluid removal device.
8. The system of claim 1 , further comprising a computer readable medium, wherein the computer readable medium comprises instructions that cause the control electronics to control the concentrate flow control element to adjust the rate at which the concentrate solution enters the fluid source based on data obtained from the first sensor and the second sensor.