Methods of treating inflammatory and autoimmune diseases with natalizumab
Natalizumab is a safe and efficacious treatment for inflammatory and autoimmune diseases, such as multiple sclerosis, Crohn's Disease, and rheumatoid arthritis. Chain swapping between natalizumab and IgG4 molecules acts to reduce the level of bivalent natalizumab present following administration of natalizumab, and thus to lower the activity of natalizumab in the patient. Differences in IgG4 levels across patients or within a single patient across time may change the pharmacokinetic profile of natalizumab. Patients with lower levels of IgG4 may experience higher nadir levels of natalizumab during a dosing period. Monitoring IgG4 and/or bivalent natalizumab levels, and determining a dose or dosage period based on the monitoring may improve the safety and/or efficacy of natalizumab therapy.
1. A method of treating a patient with multiple sclerosis or Crohn's disease with natalizumab comprising:
(a) detecting an amount of endogenous IgG4 in the patient's plasma or serum prior to initiating treatment; and
(b) administering a dose of natalizumab to the patient for a dosage period, wherein the dose is lower than 300 mg by IV infusion and/or the dosage period is longer than four weeks and the amount of endogenous IgG4 detected is below 200 μg/mL.
2. The method of claim 1 , wherein the administered dose of natalizumab is below 300 mg by IV infusion.
3. The method of claim 1 , wherein the amount of IgG4 in the patient's blood is below 200 μg/ml and the administered dose of natalizumab is administered for a dosage period longer than four weeks.
4. The method of claim 1 , further comprising monitoring the patient for indicators of serious infection and/or treating the patient with prophylaxis designed to reduce the risk of developing serious infection.
5. The method of claim 1 , further comprising monitoring the patient for indications of progressive multifocal leukoencephalopathy.
6. The method of claim 5 , wherein the monitoring detects JCV in the patient's urine, blood, and/or cerebrospinal fluid.
7. The method of claim 5 , wherein the monitoring comprises testing for clinical and/or radiologic symptoms of progressive multifocal leukoencephalopathy.
8. The method of claim 5 , further comprising, in the presence of indicators of progressive multifocal leukoencephalopathy, providing at least one treatment selected from intravenous immunoglobulin therapy, plasmapheresis, and antiviral therapy.
9. A method of inhibiting binding between an α4-integrin expressed on a leukocyte and one or more molecules selected from VCAM-1, MAdCAM-1, osteopontin, and fibronectin in a patient comprising
(a) detecting an amount of endogenous IgG4 in the patient's plasma or serum prior to initiating treatment with natalizumab; and
(b) administering a dose of natalizumab to the patient for a dosage period, wherein the dose is lower than 300 mg by IV infusion and/or the dosage period is longer than four weeks and the amount of endogenous IgG4 detected is below 200 μg/mL.
10. The method of claim 9 , wherein the administered dose of natalizumab is below 300 mg by IV infusion.
11. The method of claim 9 , wherein the amount of IgG4 in the patient's blood is below 200 μg/ml and the administered dose of natalizumab is administered for a dosage period longer than four weeks.
12. The method of claim 9 , further comprising monitoring the patient for indicators of serious infection and/or treating the patient with prophylaxis designed to reduce the risk of developing serious infection.
13. The method of claim 9 , further comprising monitoring the patient for indications of progressive multifocal leukoencephalopathy.
14. The method of claim 13 , wherein the monitoring detects JCV in the patient's urine, blood, and/or cerebrospinal fluid.
15. The method of claim 13 , wherein the monitoring comprises testing for clinical and/or radiologic symptoms of progressive multifocal leukoencephalopathy.
16. The method of claim 13 , further comprising, in the presence of indicators of progressive multifocal leukoencephalopathy, providing at least one treatment selected from intravenous immunoglobulin therapy, plasmapheresis, and antiviral therapy.
17. The method of claim 5 , wherein the monitoring comprises serially removing samples of the patient's blood, measuring the amount of IgG antibodies to JCV in the samples, and comparing the amount of the antibodies in the samples.
18. The method of claim 13 , wherein the monitoring comprises serially removing samples of the patient's blood, measuring the amount of IgG antibodies to JCV in the samples, and comparing the amount of the antibodies in the samples.