Bioactive load-bearing composites
View Patent ↗Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
1. A method of preparing an osteoproductive composite comprising:
a) blending polyetheretherketone particles and bioactive glass particles to form a particle mixture, wherein the bioactive glass particles have an average particle size of from about 10 microns to about 400 microns, and the polyetheretherketone particles have an average particle size of about 1 to about 400 microns;
b) adding a polar organic solvent to the particle mixture to form a mixture containing a weight ratio of the solvent to the particle mixture of about 1:1 to about 4:1, wherein the solvent contains less than about 5% by weight of water;
c) agitating the mixture for period of time and under conditions sufficient to achieve substantial homogeneity of the mixture; and
d) removing substantially all of the solvent from the mixture to obtain substantially homogeneous particle mixture.
2. The method of claim 1 , wherein the bioactive glass particles have an average particle size of from about 10 microns to about 150 microns.
3. The method of claim 1 , wherein the bioactive glass particles have an average particle size of from about 10 microns to about 25 microns.
4. The method of claim 1 , wherein the bioactive glass particles are present in an amount of about 5-60% by weight of the particle mixture.
5. The method of claim 1 , wherein the bioactive glass particles comprise combeite glass-ceramic.
6. The method of claim 1 , wherein the number of the polyetheretherketone particles is greater than the number of the bioactive glass particles.
7. The method of claim 1 , wherein a number ratio of the polyetheretherketone particles to the bioactive glass particles is between about 6:1 to about 10:1.
8. The method of claim 1 , wherein the particle size ratio of polyetheretherketone particles to bioactive glass particles is about 1:1.5.
9. The method of claim 1 , further comprising mixing at least one filler with the polyetheretherketone particles and the bioactive glass particles.
10. The method of claim 1 , wherein the weight ratio of the solvent to the particle mixture is about 2:1.
11. The method of claim 1 , wherein the solvent is alcohol.
12. The method of claim 1 , further comprising blending the particle mixture from the step (d).
13. The method of claim 1 , wherein the composite is bioactive in vitro.
14. A method of preparing an osteoproductive implant comprising:
a) blending polyetheretherketone particles and bioactive glass particles to form a particle mixture, wherein the bioactive glass particles have an average particle size of from about 10 microns to about 400 microns, and the polyetheretherketone particles have an average particle size of about 1 to about 400 microns;
b) adding a nonaqueous, polar organic solvent to the particle mixture to form a mixture containing a weight ratio of the solvent to the particle mixture of about 1:1 to about 4:1, wherein the solvent contains less than about 5% by weight of water;
c) agitating the mixture for a time and under conditions sufficient to achieve substantial homogeneity of the mixture;
d) removing substantially all of the solvent from the mixture to obtain substantially homogeneous particle mixture; and
e) molding the substantially homogeneous particle mixture under conditions of heat and pressure sufficient to provide an integral shaped body.
15. The method of claim 14 , wherein the molding comprises heating to a temperature sufficient to melt at least one component of the particle mixture.
16. The method of claim 14 , wherein the molding comprises applying pressure.
17. The method of claim 14 , further comprising holding the mixture for a time and at a temperature sufficient to effect curing.
18. The method of claim 14 , further comprising cooling the shaped body.
19. The method of claim 14 , further comprising cooling the shaped body to at or below ambient temperature.
20. A method of preparing an osteoproductive composite comprising:
a) preparing a bioactive glass to reduce alkali surface reactivity, wherein the bioactive glass has an average particle size of from about 10 microns to about 400 microns, and the polyetheretherketone particles have an average particle size of about 1 to about 400 microns;
b) blending polyetheretherketone particles and the bioactive glass to form a particle mixture;
c) adding a polar organic solvent to the particle mixture to form a mixture containing a weight ratio of the solvent to the particle mixture of about 1:1 to about 4:1, wherein the solvent contains less than about 5% by weight of water;
d) agitating the mixture for a period of time and under conditions sufficient to achieve substantial homogeneity of the mixture; and
e) removing substantially all of the solvent from the mixture to obtain substantially homogeneous particle mixture.
21. The method of claim 1 , wherein the solvent contains less than about 1% by weight of water.