System and method for reconstructing cardiac activation information

1. A method of reconstructing biological activation information, the method comprising:

processing a first biological signal and a second biological signal associated with an organ via a computing device to determine whether there is a point of change in a derivative of the first biological signal with respect to a derivative of the second biological signal above a threshold; and

assigning an activation onset time in the first biological signal at the point of change to define biological activation associated with the organ in the first biological signal if it is determined that the point of change is above the threshold.

2. The method of claim 1 , wherein the point of change is determined at about the same time point for the first biological signal and the second biological signal.

3. The method of claim 1 , wherein the point of change is determined from one or more of slope, amplitude, timing and shape for the first biological signal and the second biological signal.

4. The method of claim 1 , wherein determination of the point of change comprises:

forming a composite biological signal from the first biological signal and the second biological signal;

determining ratio values at a plurality of points in the first biological signal, each ratio value representing a difference between the derivative of the second biological signal and a derivative of the composite biological signal to a difference between derivative of the first biological signal and the derivative of the composite biological signal; and

selecting as the point of change in the first biological signal a point having a largest ratio value from the determined ratio values.

5. The method of claim 1 , wherein the threshold is higher than a noise level associated with the first biological signal and the second biological signal.

6. The method of claim 5 , wherein a point of change at or below the noise level is associated with one or more signals from a heart, respiratory system, gastrointestinal tract, neurological system and electronic interference.

7. The method of claim 1 , further comprising:

matching at least one characteristic of the first biological signal to at least one characteristic of a reference biological signal in a catalog of biological signals if it is determined that there is no point of change above the threshold; and

assigning an activation onset time in the first biological signal as an activation onset time of the reference biological signal to define biological activation associated with the organ in the first biological signal.

8. The method of claim 1 , further comprising performing processing and assigning to define multiple biological activations associated with the organ in the first biological signal.

9. The method of claim 1 , further comprising iteratively selecting the first biological signal and the second biological signal from a plurality of biological signals.

10. The method of claim 1 , further comprising:

iteratively selecting pairs of biological signals from a plurality of biological signals, each pair having a first biological signal and different second biological signal;

performing processing and assigning for each of the pairs to define multiple biological activations associated with the organ for the first biological signal in each of the pairs; and

reconstructing a biological activation pattern based on assigned activation onset times of biological activations from the plurality of biological signals to indicate a source of a biological rhythm disorder.

11. A system to reconstruct biological activation information comprising: at least one computing device configured to:

process a first biological signal and a second biological signal associated with an organ to determine whether there is a point of change in a derivative of the first biological signal with respect to a derivative of the second biological signal above a threshold; and

assign an activation onset time in the first biological signal at the point of change to define biological activation associated with the organ in the first biological signal if it is determined that the point of change is above the threshold.

12. A system of claim 11 , further comprising a computer readable medium comprising instructions, which when executed by the at least one computing device, cause the at least one computing device to process and assign.

13. The system of claim 11 , wherein the point of change is determined at about the same time point for both the first biological signal and the second biological signal.

14. The system of claim 11 , wherein the at least one computing device is further configured to:

form a composite biological signal from the first biological signal and the second biological signal;

determine ratio values at a plurality of points in the first biological signal, each ratio value representing a difference between the derivative of the second biological signal and a derivative of the composite biological signal to a difference between the derivative of the first biological signal and the derivative of the composite biological signal; and

select as the point of change in the first biological signal a point having a largest ratio value from the determined ratio values.

15. The system of claim 11 , wherein the at least one computing device is further configured to:

match at least one characteristic of the first biological signal to at least one characteristic of a reference biological signal in a catalog of biological signals if it is determined that there is no point of change above the threshold; and

assign an activation onset time in the first biological signal as an onset time of the reference biological signal to define biological activation associated with the organ in the first biological signal.

16. The system of claim 11 , wherein the at least one computing device is further configured to perform processing and assigning to define multiple biological activations associated with the organ in the first biological signal.

17. The system of claim 11 , wherein the at least one computing device is further configured to iteratively select the first biological signal and the second biological signal from a plurality of biological signals.

18. The system of claim 11 , further comprising a catheter with at least a first sensor and a second sensor to detect the first biological signal and the second biological signal, respectively.

19. The system of claim 11 , wherein the at least one computing device is further configured to:

iteratively select pairs of biological signals from a plurality of biological signals, each pair having a first biological signal and different second biological signal;

process and assign for each of the pairs to define multiple biological activations associated with the organ for the first biological signal in each of the pairs;

reconstruct a biological activation pattern based on assigned activation onset times of biological activations from the plurality of biological signals to indicate a source of a biological rhythm disorder; and

display the reconstructed biological activation pattern to facilitate treatment of organ tissue at the source to suppress, lessen or eliminate the biological rhythm disorder.

20. A method of treating a biological rhythm disorder, the method comprising:

iteratively accessing a first biological signal and a second biological signal from a plurality of biological signals associated with an organ;

processing the first biological signal and the second biological signal via a computing device to determine whether there are points of change in a derivative of the first biological signal with respect to a derivative of the second biological signal above a threshold;

assigning activation onset times to the first biological signal at the points of change to define biological activations associated with the organ in the first biological signal if it is determined that the points of change are above the threshold;

reconstructing a biological activation pattern based on the assigned activation onset times to indicate a source of the biological rhythm disorder; and

treating organ tissue at the source to suppress or eliminate the biological rhythm disorder.