Polymer scaffold degradation control via chemical control
View Patent ↗A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.
1. A method for synthesizing a copolymer comprising a known stoichiometric ratio of maleate and fumarate monomers, the method comprising blending malonyl chloride and fumaryl chloride monomers in a predetermined ratio with a polyalcohol species at low temperature with an inert gas sparge.
2. The method of claim 1 further comprising, identifying a desired density for the copolymer; and selecting the predetermined ratio of maleate to fumarate dichloride monomers based on the desired density.
3. The method of claim 1 wherein the reaction is carried out at a temperature lower than 10° C.
4. The method of claim 1 wherein the reaction is carried out at 0° C.
5. The method of claim 1 wherein the inert gas is nitrogen.
6. The method of claim 1 wherein the polyalcohol species is butane diol or glycerol.
7. The method of claim 1 wherein synthesis is carried out in the presence of a proton scavenger.
8. The method of claim 1 wherein synthesis is carried out in the absence of a proton scavenger.