Photodynamic therapy for tumors with localized delivery

1. A method of treatment of tumors comprising the steps of:

positioning a catheter having at least one inflatable balloon positioned adjacent a distal end thereof in a bodily cavity adjacent to target tissue;

delivering a photosensitizing agent to the target tissue via at least one opening in said catheter;

radiating the target tissue with light; and

repeatedly inflating and at least partially deflating said at least one inflatable balloon by supplying fluid thereto and withdrawing fluid therefrom via said catheter such that a resecting outer surface of said balloon contacts the radiated target tissue and resects said tissue.

2. The method of claim 1 , wherein the photosensitizing agent is an up-converting phosphor.

3. The method of claim 1 , wherein the photosensitizing agent comprises a biomarker, and the method further comprises the step of monitoring absorption of the photosensitizing agent into the tumor tissue via the biomarker.

4. The method of claim 3 , wherein the biomarker is a fluorinated compound.

5. The method of claim 3 , wherein the biomarker is a radiopaque marker.

6. The method of claim 1 , wherein the steps of delivering the photosensitizing agent to the target tissue and radiating the target tissue with light are synchronized.

7. The method of claim 1 , further comprising delivering an oxygenating agent to the target tissue and radiating the target tissue with ionizing radiation.

8. The method of claim 7 , wherein the oxygenating agent comprises oxygen.

9. The method of claim 7 , wherein the oxygenating agent comprises doxorubicin.

10. The method of claim 1 , wherein said catheter has a first lumen through which fluid is supplied to said at least one balloon to inflate the balloon and a second lumen for supplying the photosensitizing agent to the target tissue via said at least one opening in the catheter.

11. The method of claim 1 , wherein the step of delivering a photosensitizing agent to the target tissue comprises injecting the photosensitizing agent into the target tissue.

12. The method of claim 1 , wherein the step of radiating the target tissue with light comprises radiating the target tissue from an external source positioned outside of a patient's body.

13. The method of claim 1 , wherein the step of radiating the target tissue with light comprises radiating the target tissue locally by positioning a light source in the bodily cavity adjacent to the target tissue.

14. The method of claim 13 , wherein the light source positioned in the bodily cavity comprises a probe for radiating the target tissue.

15. The method of claim 1 , further comprising the step of delivering a vaso-occlusive agent to the target tissue.

16. The method of claim 15 , wherein the vaso-occlusive agent comprises an antifibrinolytic drug eluting nanoparticle.

17. The method claim 16 , wherein the nanoparticle comprises a tranexamic acid eluting PLGA microsphere.

18. The method of claim 1 , further comprising the step of repeating the steps of radiating the target tissue and resecting the target tissue.

19. The method of claim 1 , wherein said at least one inflatable balloon comprises a first balloon, and wherein said catheter further comprises a second balloon positioned distally of the first balloon and a third balloon positioned proximally of the first balloon, and wherein the method further comprises the step of inflating the second and third balloons by supplying fluid thereto to create a chamber therebetween.

20. The method of claim 1 , wherein the resecting outer surface comprises a mesh disposed on an outer wall of said at least one balloon.

21. The method of claim 1 , wherein the resecting outer surface comprises a textured surface on an outer wall of said at least one balloon.