NOVEL COCHLEATE FORMULATIONS
A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca 2+ or Zn 2+ , forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
1 . A cochleate composition comprising a population of cochleates, wherein the cochleates comprise:
a negatively charged first lipid;
a divalent cation or higher valency cation and
an additional biologically relevant molecule,
wherein the mean particle size of the cochleates is less than one micron.
2 - 72 . (canceled)