IP Library › Granted Patent US 8,450,321
Granted Patent B2
US 8,450,321 · App. 13/441,441 · Granted May 28, 2013

6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor

Inventors: Scott A. Mitchell (East Haven, CT); Kevin S. Currie (North Branford, CT)
Assignee: Gilead Connecticut, Inc.
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Quick Facts
Patent No.
US 8,450,321
App. No.
13/441,441
Granted
May 28, 2013
Kind
B2
Abstract

An imidazopyrazine having the structure or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Claims (5)

1. A compound having the structure:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising

the compound of claim 1 ; and

at least one pharmaceutically acceptable vehicle selected from the group consisting of carriers, adjuvants, and excipients.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2020
From: GILEAD CONNECTICUT, INC.
To: KRONOS BIO, INC.
Reel/Frame 053927/0969 →
MERGER AND CHANGE OF NAME Recorded Sep 17, 2020
From: COUGAR MERGER SUB, INC.; CGI PHARMACEUTICALS, INC.; CGI PHARMACEUTICALS, INC.
To: GILEAD CONNECTICUT, INC.
Reel/Frame 053799/0190 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CITY NAME IN THE ADDRESS OF THE ASSIGNEE FROM FORSTER CITY TO FOSTER CITY PREVIOUSLY RECORDED ON REEL 028008 FRAME 0234. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNEE. Recorded Apr 24, 2013
From: MITCHELL, SCOTT A.; CURRIE, KEVIN S.
To: GILEAD CONNECTICUT, INC.
Reel/Frame 030292/0960 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 6, 2012
From: MITCHELL, SCOTT A.; CURRIE, KEVIN S.
To: GILEAD CONNECTICUT, INC.
Reel/Frame 028008/0234 →
Continuity (5)
Continuation In Part 12632140 · Dec 7, 2009
Provisional Application 61240979 · Sep 9, 2009
Provisional Application 61140514 · Dec 23, 2008
Provisional Application 61120587 · Dec 8, 2008
Related Publication 20120220582A1 · Aug 30, 2012