Stirred tank reactor systems and methods of use
View Patent ↗A reactor system includes a flexible bag having an interior surface bounding a compartment. An elongated tubular connector is disposed within the compartment of the flexible bag, the tubular connector having a first end and an opposing second end, the first end of the tubular connector being coupled with the flexible bag. An impeller is disposed within the compartment of the flexible bag and is secured to the tubular connector. A drive shaft is removably received within the tubular connector such that rotation of the drive shaft facilitates rotation of the impeller.
1. A reactor system comprising:
a flexible bag having an interior surface bounding a compartment;
an elongated tubular connector disposed within the compartment of the flexible bag, the tubular connector having a first end and an opposing second end;
a rotational assembly which includes a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the hub having a passageway extending therethrough, the first end of the tubular connector being secured to the hub;
an impeller disposed within the compartment of the flexible bag, the impeller being coupled with the second end of the tubular connector; and
a drive shaft removably received within the tubular connector and removably coupled with the impeller such that continuous rotation of the drive shaft facilitates continuous rotation of the impeller.
2. The reactor system as claimed in claim 1 , wherein the drive shaft directly engages the impeller.
3. The reactor system as claimed in claim 1 , wherein the drive shaft engages the hub such that rotation of the drive shaft facilitates rotation of the hub.
4. The reactor system as claimed in claim 1 , wherein rotation of the drive shaft facilitates rotation of the impeller, hub, and tubular connector.
5. The reactor system as claimed in claim 1 , further comprising an annular seal disposed between the hub and the casing so as to form an aseptic seal therebetween.
6. The reactor system as claimed in claim 1 , further comprising a bearing disposed between the hub and the casing.
7. The reactor system as claimed in claim 1 , wherein the drive shaft has a frustoconical head disposed outside of the tubular connector.
8. The reactor system as claimed in claim 1 , wherein the impeller is secured to the second end of the tubular connector.
9. The reactor system as claimed in claim 1 , wherein the drive shaft is linear.
10. The reactor system as claimed in claim 1 , wherein the tubular connector comprises a flexible tube.
11. A method for mixing a fluid, the method comprising:
delivering a fluid into a compartment of a flexible bag, an elongated tubular connector being coupled to the flexible bag and projecting into the compartment thereof, an impeller being coupled with the tubular connector and disposed within the compartment;
removably inserting a drive shaft into the tubular connector so that the drive shaft engages with the impeller;
continuously rotating the drive shaft so that the drive shaft continuously rotates the impeller and mixes the fluid within the compartment; and
further comprising a casing mounted to the flexible bag and a hub rotatably mounted to the casing, the hub being coupled to the tubular connector and having a passageway extending therethrough, the step of removably inserting the drive shaft comprising passing the drive shaft through the passageway of the hub.
12. The method as recited in claim 11 , wherein a first end of the tubular connector is rotatably coupled to the flexible bag so that rotation of the drive shaft causes rotation of the first end of the tubular connector with respect to the flexible bag.
13. The method as recited in claim 11 , further comprising rotating the drive shaft so that the drive shaft rotates the impeller, tubular connector, and hub relative to the flexible bag.
14. The method as recited in claim 11 , wherein the step of removably inserting the drive shaft comprises passing the drive shaft through the passageway of the hub so that the drive shaft engages with the hub.
15. The reactor system as recited in claim 1 , wherein the drive shaft extends through the tubular connector to directly engage the impeller.
16. The reactor system as recited in claim 1 , wherein continuous rotation of the drive shaft facilitates continuous rotation of the tubular connector.
17. The reactor system as recited in claim 1 , wherein the first end of the tubular connector is rotatably coupled with the flexible bag.
18. The reactor system as recited in claim 1 , further comprising:
a housing;
a motor mount disposed on the housing and having a passage extending therethrough;
a drive motor coupled with the motor mount for selectively rotating the motor mount relative to the housing, the drive shaft being engaged with the motor mount so that rotation of the motor mount by the drive motor facilitates continuous rotation of the drive shaft.
19. The reactor system as recited in claim 18 , wherein:
the drive shaft has a first engaging portion with a substantially frustoconical configuration; and
the motor mount has a second engaging portion having a substantially frustoconical configuration complementary to the first engaging portion, the first engaging portion being received within the second engaging portion.