IP Library › Granted Patent US 8,497,357
Granted Patent B2
US 8,497,357 · App. 13/446,652 · Granted Jul 30, 2013

Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom

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Quick Facts
Patent No.
US 8,497,357
App. No.
13/446,652
Granted
Jul 30, 2013
Kind
B2
Abstract

A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.

Claims (4)

1. A hydrogel comprising,

a co-polymerization product of a PEG multiacrylate and a heterobifunctional PEG conjugate wherein,

(i) the multiacrylate has the formula of CH 2 ═CHCO 2 -PEG-O 2 CCH═CH 2 , wherein PEG is polyethylene glycol, and

(ii) the conjugate has the formula of (CH 2 ═CZ—CO 2 -PEG-W-L) x -T, wherein Z is an alkyl group or hydrogen atom, W is a hydrolytically unstable linkage comprising a hydrolysable covalent bond, L is a covalent linkage, PEG is a polyethylene glycol, T is a protein, and x is number from 1 to 10.