Treatment and diagnosis of inflammatory disorders and HIV
View Patent ↗This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
1. A method of ameliorating symptoms of inflammatory autoimmune psoriasis in a mammalian subject in need thereof comprising administering to said subject a composition consisting of a pharmaceutically acceptable carrier and a therapeutically effective amount of an isolated leukotoxin set forth as SEQ ID NO: 1.
2. The method of claim 1 , wherein the autoimmune psoriasis is characterized by leukocytes expressing upregulated and activated leukocyte function antigen-1 (LFA-1) on their surface.
3. The method of claim 1 , wherein the leukotoxin is purified.
4. The method of any one of claims 1 - 3 , wherein the leukotoxin is obtained from Aggregatibacter actinomycetemcomitans.