IP Library Granted Patent US 9,278,943
Granted Patent B2
US 9,278,943 · App. 13/450,854 · Granted Mar 8, 2016

Methods of using as analgesics 1-benzyl-1-hydroxy-2, 3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds

Inventors: Bertrand Leblond (Paris, FR); Eric Beausoleil (Paris, FR); Thierry Taverne (St. Martin Boulogne sur Mer, FR); John E. Donello (Dana Point, CA); Fabien (Jacques) Schweighoffer (Fontenay sous Bois, FR)
Assignees: Exonhit Therapeutics SA; Allergan, Inc.
C07D265/30A61K31/40A61K31/4025A61K31/4409A61K31/4439A61K31/4545A61K31/4709A61K31/496A61K31/5375A61K31/5377A61K31/541C07D213/64C07D295/12C07D319/18
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Quick Facts
Patent No.
US 9,278,943
App. No.
13/450,854
Granted
Mar 8, 2016
Kind
B2
Abstract

The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.

Claims (22)

1. A method of treating pain in a mammal in need of such treatment, comprising administering to said mammal a compound selected from the group consisting of the compounds shown by structural formulas below

or any pharmaceutically acceptable salt thereof.

2. A method in accordance with claim 1 wherein the compound has the formula

or any pharmaceutically acceptable salt thereof.

3. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

4. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

5. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

6. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

7. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

8. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

9. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

10. A method in accordance with claim 1 wherein the compound has the formula

or any other pharmaceutically acceptable salt of said compound.

11. A method in accordance with claim 1 wherein said pain is chronic pain.

12. A method in accordance with claim 11 , wherein said chronic pain results from peripheral neuropathy.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 6, 2012
From: ALLERGAN, INC.
To: EXONHIT THERAPEUTICS SA; ALLERGAN, INC.
Reel/Frame 028509/0503 →
Continuity (3)
Division 11814604
Provisional Application 60647271 · Jan 26, 2005
Related Publication 20120225881A1 · Sep 6, 2012