Pyridinium boronic acid quenchers for use in analyte sensors
View Patent ↗Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
1. An analyte sensor comprising:
a fluorophore comprising a pyranine derivative configured to absorb light at a first wavelength and emit light at a second wavelength; and
a quencher having the structure:
2. The analyte sensor of claim 1 , wherein said pyranine derivative is a hydroxypyrene trisulfonamide derivative.
3. The analyte sensor of claim 1 , wherein said pyranine derivative is a polymeric derivative of hydroxypyrene trisulfonic acid.
4. The analyte sensor of claim 1 , wherein said pyranine derivative is HPTS-TrisCys-MA.
5. The analyte sensor of claim 1 , wherein the said quencher is in the form of a polymer.
6. An analyte sensor comprising:
a fluorophore comprising a pyranine derivative configured to absorb light at a first wavelength and emit light at a second wavelength; and
a quencher having the following structure:
(P-2), wherein n=1-10.