Crosslinked zwitterionic hydrogels
View Patent ↗Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.
1. A compound represented by the formula:
wherein
R 1 and R 2 are independently selected from the group consisting of hydrogen, fluorine, trifluoromethyl, C1-C6 alkyl, and C6-C12 aryl groups;
R 3 is selected from the group consisting of C1-C6 alkyl, C6-C12 aryl, CH 2 ═C(R 1 )-L 1 -, and CH 2 ═C(R 2 )-L 2 -;
L 1 and L 2 are independently selected from the group consisting of —C(═O)O—(CH 2 ) n — and —C(═O)NH—(CH 2 ) n —, wherein n is an integer from 1 to 20;
L 3 is —(CH 2 ) n —, where n is an integer from 1 to 20;
A 1 is C, S, SO, P, or PO;
X − is the counter ion associated with the N + cationic center; and
M + is a counterion associated with the (A 1 =O)O − anionic center.
2. The compound of claim 1 , wherein R 1 , R 2 , and R 3 are independently selected from the group consisting of C1-C6 alkyl.
3. The compound of claim 1 , wherein L 1 and L 2 are —C(═O)O—(CH 2 ) n —, wherein n is 1-6.
4. The compound of claim 1 , wherein L 3 is —(CH 2 ) n —, where n is an integer from 1-6.
5. The compound of claim 1 , wherein A 1 is C or SO.
6. The compound of claim 1 , wherein M + at each occurrence is a metal or organic ion.
7. The compound of claim 1 , wherein X − at each occurrence is halide, carboxylate, alkylsulfonate, sulfate; nitrate, perchlorate, tetrafluoroborate, hexafluorophosphate, trifluoromethylsulfonate, bis(trifluoromethylsulfonyl)amide, lactate, or salicylate.