Phenoxy acetic acids as PPAR delta activators
View Patent ↗The present invention describes phenoxy-acetic acids and pharmaceutical compositions containing the same and methods of using the same. The phenoxy-acetic acids are activators of PPAR-δ and should be useful for treating conditions mediated by the same.
1. A method of treating a renal disease selected from the group consisting of glomerulonephritis, glomerulosclerosis, nephrotic syndrome, and hypertensive nephrosclerosis comprising: administering to a human subject {4-[3-isobutoxy-5-(3-morpholin-4-yl-prop-1-ynyl)-phenylsulfanyl]-2-methyl-phenoxy}-acetic acid or a pharmaceutically acceptable salt thereof.
2. A method of treating a renal disease selected from the group consisting of glomerulonephritis, glomerulosclerosis, nephrotic syndrome, and hypertensive nephrosclerosis comprising: administering to a human subject {4-[3-isobutoxy-5-(3-morpholin-4-yl-prop-1-ynyl)-benzylsulfanyl]-2-methyl-phenoxy}-acetic acid or a pharmaceutically acceptable salt thereof.
3. A method of treating a cardiovascular disease selected from the group consisting of atherosclerosis, mortality reduction, coronary artery disease, coronary heart diseases, heart attack, myocardial ischemia, myocardial infarct, coronary infarct, transient ischemic attack (TIA), and stroke comprising: administering to a human subject {4-[3-isobutoxy-5-(3-morpholin-4-yl-prop-1-ynyl)-phenylsulfanyl]-2-methyl-phenoxy}-acetic acid or a pharmaceutically acceptable salt thereof.
4. A method of treating a cardiovascular disease selected from the group consisting of atherosclerosis, mortality reduction, coronary artery disease, coronary heart diseases, heart attack, myocardial ischemia, myocardial infarct, coronary infarct, transient ischemic attack (TIA), and stroke comprising: administering to a human subject {4-[3-isobutoxy-5-(3-morpholin-4-yl-prop-1-ynyl)-benzylsulfanyl]-2-methyl-phenoxy}-acetic acid or a pharmaceutically acceptable salt thereof.