Granted Patent
B2
US 8,653,103 · App. 13/467,185 · Granted Feb 18, 2014
Solid forms of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
Inventors:
Ali Keshavarz-Shokri (San Diego, CA); Beili Zhang (San Diego, CA); Mariusz Krawiec (Marlborough, MA)
Assignee:
Vertex Pharmaceuticals Incorporated
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Abstract
The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.
Claims (1)
1. A pharmaceutical composition comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid characterized as Form I, a pharmaceutically acceptable carrier, and N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide.
Assignments (5)
RELEASE OF SECURITY INTEREST
Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
ASSIGNEE CHANGE OF ADDRESS
Recorded Feb 4, 2016
From: VERTEX PHARMACEUTICALS INCORPORATED
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 037697/0001 →
ASSIGNEE CHANGE OF ADDRESS
Recorded Feb 2, 2016
From: VERTEX PHARMACEUTICALS INCORPORATED
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 037681/0375 →
SECURITY INTEREST
Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 30, 2012
From: KESHAVARZ-SHOKRI, ALI; ZHANG, BEILI; KRAWIEC, MARIUSZ
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 028874/0295 →
Continuity (3)
Provisional Application
61012162
· Dec 7, 2007