Xinafoate salt of N4-(2,2-difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-N2-[3-(methylaminocarbonylmethyleneoxy)phenyl]2,4-pyrimidinediamine
View Patent ↗The present invention relates to the xinafoate salt of N4-[(2,2-difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-N2-[3-(methylaminocarbonylmethyleneoxy)phenyl]-2,4-pyrimidinediamine. This compound is a suitable drug substance and is useful in the treatment of conditions including asthma.
1. A method for treating a disease for which a Syk inhibitor is indicated in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of the xinafoate salt of N4-[(2,2-difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-N2-[3-(methylaminocarbonylmethyleneoxy)phenyl]-2,4-pyrimidinediamine.
2. The xinafoate salt of claim 1 having shifts at about −69.2, −72.4 and −164.0 ppm when characterized by fluorine solid state NMR referenced to an external sample of trifluoroacetic acid (50% by volume in H 2 O) assigned a resonance at −76.54 ppm.