IP Library › Patent Application 13472368
Patent Application
App. No. 13/472,368

FORMULATIONS AND METHODS FOR TREATING AMYLOIDOSIS

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Quick Facts
Patent No.
US None
App. No.
13/472,368
Abstract

Methods, formulations, and compositions for the treatment of amyloidosis are described.

Claims (5)

1 . A method of treating or preventing AA amyloidosis in a target subject comprising,

administering to the target subject a therapeutically effective amount of a compound having the formula:

Y—(CH 2 ) n —[CH 2 Y] m   (I)

wherein Y is SO 3 X or OSO 3 X independently chosen for each occurrence; X is cationic group independently chosen for each occurrence; n is 1, 2, 3 or 4; and m is 1 or 2, such that AA amyloidosis is treated or prevented while maintaining an acceptable tolerance index (ATI) for a parameter associated with renal impairment (PRI),

wherein the target subject is being treated for AA amyloidosis and has or is susceptible to a parameter associated with renal impairment.