System and method for spray drying a liquid
View Patent ↗Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
1. A spray drying chamber, comprising:
an elongated side wall extending between two open ends and defining a central lumen receiving an aerosolized flow of liquid sample and a drying gas to produce a spray dried powder, the central lumen extending along a longitudinal axis;
a reducing wall extending between an open widened end and an open narrowed end, the opened widened end attached to one of the open ends of the elongated side wall; and
an attachment flange attached to the open narrowed end of the reducing wall and adapted for attachment to a collection device for collecting the spray dried powder, the elongated side wall, reducing wall, and attachment flange defining a fluid-tight open channel extending along the longitudinal axis.
2. The spray drying chamber of claim 1 , wherein at least one of the elongated side wall, the reducing wall, and the attachment flange comprises a plurality of sub-sections.
3. The spray drying chamber of claim 2 , wherein the elongated side wall, the reducing wall, and the attachment flange of at least one sub-section. are contiguous.
4. The spray drying chamber of claim 1 , wherein at least one of the elongated side wall, the reducing wall, and the attachment flange are formed from a thin-walled, collapsible material.
5. The spray drying assembly of claim 4 , wherein at least a portion of the elongated side wall is substantially transparent, allowing for observation of an interior region of the spray drying chamber.