Hydrolytically stable maleimide-terminated polymers
View Patent ↗The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
1. A conjugate formed by the reaction of an active agent comprising a reactive amino group and a thiol group with a water-soluble polymer having the structure:
wherein (n) is 3 to 3000 and further wherein the conjugate so formed has of the following structure
wherein (n) is 3 to 3000 and —NH— of “—NH-active agent” corresponds to the amino group of the active agent, wherein the active agent is selected from the group consisting of peptides and proteins.
2. The conjugate of claim 1 , wherein (n) is 20 to 1000.
3. The conjugate of claim 1 , wherein the active agent is a peptide.
4. The conjugate of claim 1 , wherein the active agent is a protein.