Adhesive compositions for medical use: single additive as both the thickening agent and the accelerator
The present invention relates to compositions of cyanoacrylate monomer, a method of improving the viscosity and the curing speed with a single additive and a process of providing sterilized cyanoacrylate adhesive compositions for application in the medical field.
1. A sterile cyanoacrylate adhesive composition, comprising a cyanoacrylate monomer stabilized with 2000 to 8000 parts per million of the cyanoacrylate monomer of butylated hydroxyl anisole and 10 to 200 parts per million of the cyanoacrylate monomer of sulfur dioxide, homogenously mixed together with about 0.04% to about 0.5% by weight of the composition of a poloxamer, wherein the composition is sterilized by irradiation and has a viscosity between about 20 centipoise to about 2000 centipoise following sterilization.
2. The sterile adhesive composition of claim 1 wherein the viscosity of the composition is between about 20 and about 1000 centipoise.
3. The sterile adhesive composition of claim 1 wherein the viscosity of the composition is between about 20 and about 200 centipoise.
4. The sterile adhesive composition of claim 1 wherein the viscosity of the composition is between about 500 and about 2000 centipoise.
5. The sterile adhesive composition of claim 1 wherein the viscosity of the composition is between about 1000 and about 2000 centipoise.
6. The adhesive composition of claim 1 wherein the poloxamer is selected from the group consisting of poloxamer 238, poloxamer 188, poloxamer 108, poloxamer 338, poloxamer 407, and mixtures thereof.
7. The sterile cyanoacrylate adhesive composition of claim 6 , wherein said poloxamer is poloxamer 407 in an amount of about 0.04 to about 0.22% by weight of the composition.
8. The sterile cyanoacrylate adhesive composition of claim 6 , wherein said poloxamer is poloxamer 238 in an amount of 0.16% to 0.45% by weight of the composition.
9. The sterile cyanoacrylate adhesive composition of claim 6 , wherein said poloxamer is poloxamer 108 in an amount of 0.1% to 0.2% by weight of the composition.
10. The sterile cyanoacrylate adhesive composition of claim 6 , wherein said poloxamer is poloxamer 188 in an amount of 0.06% to 0.4% by weight of the composition.
11. The sterile cyanoacrylate adhesive composition of claim 6 , wherein said poloxamer is poloxamer 338 in an amount of 0.1% to 0.5% by weight of the composition.
12. The composition of claim 1 , wherein the cyanoacrylate monomer is a 2-cyanoacrylate ester selected from the group consisting of an alkyl cyanoacrylate ester, an alkoxyl cyanoacrylate ester, a cycloalkyl cyanoacrylate ester, and an alkylalkoxyl cyanoacrylate ester.
13. The sterile cyanoacrylate adhesive composition of claim 1 , wherein the cyanoacrylate monomer comprises 2-octyl cyanoacrylate monomer.
14. A viscous, sterile cyanoacrylate adhesive composition, comprising a cyanoacrylate monomer stabilized with 2000 to 8000 parts per million of the cyanoacrylate monomer of butylated hydroxyl anisole and 10 to 6000 parts per million of the cyanoacrylate monomer of sulfur dioxide, and homogenously mixed together with about 0.04% to about 0.5% by weight of the composition of a poloxamer, wherein the composition is sterilized by irradiation, and the sterilized composition comprises a gel.
15. The viscous, sterile cyanoacrylate adhesive composition of claim 14 , wherein the poloxamer is selected from the group consisting of poloxamer 238, poloxamer 188, poloxamer 108, poloxamer 338, poloxamer 407, and mixtures thereof.
16. The viscous, sterile cyanoacrylate adhesive composition of claim 14 , wherein said poloxamer is poloxamer 407 in an amount of about 0.04% to about 0.22% by weight of the composition.
17. The viscous, sterile cyanoacrylate adhesive composition of claim 14 , wherein said poloxamer is poloxamer 108 in an amount of 0.1% to 0.2% by weight of the composition.
18. The viscous, sterile cyanoacrylate adhesive composition of claim 14 , wherein said poloxamer is poloxamer 188 in an amount of 0.06% to 0.4% by weight of the composition.
19. The sterile cyanoacrylate adhesive composition of claim 14 , wherein the cyanoacrylate monomer comprises 2-octyl cyanoacrylate monomer.
20. A sterile cyanoacrylate adhesive composition, comprising a cyanoacrylate monomer stabilized with 2000 to 8000 parts per million of the cyanoacrylate monomer of butylated hydroxyl anisole and 10 to 200 parts per million of the cyanoacrylate monomer of sulfur dioxide, homogenously mixed together with about 0.04% to about 0.5% by weight of the composition of a poloxamer selected from the group consisting of poloxamer 108, poloxamer 338, and poloxamer 407, wherein the composition is sterilized by irradiation and has a viscosity between about 20 centipoise to about 2000 centipoise following sterilization.