Oxidized regenerated cellulose hemostatic powders and methods of making
The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and/or into the wound of a patient.
1. A hemostatic material comprising a ball milled compacted ORC powder comprising particles having average aspect ratio from about 1 to about 18, said powder having tapped density of at least 0.45 g/cm 3 , an average particle size of 1.75 microns to 116 microns with a median size of 36 microns and a flowability of at least 7.5 cm/s.
2. The hemostatic material of claim 1 , wherein said material further comprises an additive, wherein said additive is CMC or other polysaccharides, calcium salt, anti-infective agent, hemostasis promoting agent, gelatin, collagen, or combinations thereof.
3. A hemostatic paste comprising the hemostatic material according to claim 1 and a saline solution.
4. The hemostatic paste of claim 3 , wherein the paste has a viscosity of over 10000 Pa-s.
5. The hemostatic material of claim 1 , said powder comprising particles having an average aspect ratio from about 1 to about 5, a tapped density of at least 0.67 g/cm 3 and flowability of at least 70.
6. A method of making the hemostatic material of claim 1 comprising the steps of: introducing an ORC-based material into a compaction device;
compacting the ORC-based material into a powder by ball-milling, until said powder reaches an aspect ratio of from about 1 to about 18.
7. The method of claim 6 , wherein said ORC material is ORC fabric, ORC non-woven, or shredded ORC material.
8. The method of claim 6 further comprising the step of mixing the ORC material with an additive, wherein said additive is CMC, calcium salt, anti-infective agent, hemostasis promoting agent, gelatin, collagen, saline, or combinations thereof.
9. A method of treating a wound comprising the steps of applying the hemostatic powder of claim 1 onto and/or into the wound of a patient.