Methods for preventing flea allergy dermatitis in companion animals
View Patent ↗Methods for reducing the incidence of flea allergy dermatitis (FAD) in a companion animal are disclosed, the methods directed to inhibiting blood feeding by ectoparasites on a companion animal. The methods of the present invention involve administering a pesticide composition comprising cyphenothrin to a companion animal, specifically dogs and cats, in doses and proportions which are parasiticidally effective against a variety of ectoparasites, and in formulations which are convenient for topical application to the animal's skin, preferably localized over a small surface area. Such methods are useful in preventing and/or reducing the incidence of flea allergy dermatitis.
1. A method for reducing the incidence of flea allergy dermatitis in a companion animal by reducing blood feeding by ectoparasites on the companion animal by at least 80%, the method comprising: administering a composition comprising up to about 50% (w/w) cyphenothrin and about 50% to about 85% (w/w) organic solvent, wherein the composition is administered in a volume sufficient to deliver a dosage of cyphenothrin ranging from about 0.1 mg/kg to about 40 mg/kg of animal weight.
2. The method of claim 1 , wherein composition is a spot-on composition.
3. The method of claim 2 , wherein the method further comprises administering a localized cutaneous application of the spot-on composition between the shoulders of the companion animal.
4. The method of claim 1 , wherein blood feeding by ectoparasites is reduced by at least 90%.
5. The method of claim 1 , wherein the ectoparasite is a flea.
6. The method of claim 5 , wherein the flea is Ctenocephalides felis.
7. The method of claim 1 , wherein the composition comprises between about 20% to about 30% (w/w) cyphenothrin.
8. The method of claim 1 , wherein the composition is administered as a one-time treatment.
9. The method of claim 1 , wherein the composition is administered once every five weeks.
10. The method of claim 1 , wherein the composition is administered once every six weeks.
11. The method of claim 1 , wherein the companion animal is a dog.
12. The method of claim 1 , wherein the composition further comprises about 1% to about 10% (w/w) of an antioxidant.
13. The method of claim 12 , wherein the antioxidant comprises a vitamin E compound.
14. The method of claim 12 , wherein the antioxidant is selected from the group consisting of tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, tocopherol succinate, ascorbyl tocopherol phosphate, dioleyl tocopherol methylsilanol, tocophersolan, tocopherol linoleate/oleate, and combinations thereof.
15. The method of claim 14 , wherein the antioxidant is tocopherol nicotinate.
16. The method of claim 1 , wherein the composition further comprises about 1% to about 10% (w/w) of an insect growth regulator.
17. The method of claim 1 , wherein the composition comprises about 1% to about 5% (w/w) of an insect growth regulator.
18. The method of claim 17 , wherein the insect growth regulator is a juvenile hormone mimic selected from the group consisting of fenoxycarb, hydroprene, kinoprene, methoprene, pyriproxyfen, triprene, and combinations thereof.
19. The method of claim 13 , wherein the insect growth regulator is pyriproxyfen.
20. The method of claim 1 , wherein the composition comprises between about 1% to about 50% (w/w) cyphenothrin.
21. The method of claim 1 , wherein the organic solvent comprises diethylene glycol monoethyl ether.
22. The method of claim 1 , wherein the composition is administered once every four weeks.
23. A method of reducing the incidence of flea allergy dermatitis in a companion animal by reducing blood feeding by ectoparasites on the companion animal by at least 80%, the method comprising: administering a composition comprising up to about 50% (w/w) cyphenothrin, up to about 5% (w/w) insect growth regulator, and about 50% to about 85% (w/w) diethylene glycol monoethyl ether, wherein the composition is administered once every four weeks in a volume sufficient to deliver a dosage of cyphenothrin ranging from about 0.1 mg/kg to about 40 mg/kg of animal weight.
24. A method of reducing the incidence of flea allergy dermatitis in a companion animal by reducing blood feeding by ectoparasites on the companion animal by at least 80%, the method comprising: administering a composition comprising about 20% (w/w) cyphenothrin, about 2% (w/w) pyriproxyfen, and about 78% (w/w) diethylene glycol monoethyl ether, wherein the composition is administered once every four weeks in a volume sufficient to deliver a dosage of cyphenothrin ranging from about 0.1 mg/kg to about 40 mg/kg of animal weight.
25. A method of reducing the incidence of flea allergy dermatitis in a companion animal by reducing blood feeding by ectoparasites on the companion animal by at least 80%, the method comprising: administering a composition comprising about 30% (w/w) cyphenothrin, about 2% (w/w) pyriproxyfen, and about 68% (w/w) diethylene glycol monoethyl ether, wherein the composition is administered once every four weeks in a volume sufficient to deliver a dosage of cyphenothrin ranging from about 0.1 mg/kg to about 40 mg/kg of animal weight.
26. A method of reducing the incidence of flea allergy dermatitis in a dog weighing between 11 and 20 pounds by reducing blood feeding by ectoparasites on the dog by at least 80%, the method comprising:
(a) removing one 4.0 mL tube containing a composition comprising about 30% (w/w) cyphenothrin, about 2% (w/w) pyriproxyfen, and about 68% (w/w) diethylene glycol monoethyl ether from a package;
(b) opening the tube to form an open end of the tube;
(c) placing the open end of the tube onto the dog's skin; and
(d) squeezing the tube to apply the composition to the dog's skin.
27. The method of claim 26 , further comprising disposing of the tube in a trash receptacle after application of the composition to the dog.
28. The method of claim 26 , wherein the open end of the tube is placed on a starting location high on the back of the dog's neck.
29. The method of claim 28 , further comprising squeezing the tube to deposit the composition as a stripe from the starting location to an ending point.
30. The method of claim 29 , wherein the ending point is midway between the dog's neck and tail.
31. The method of claim 26 , further comprising repeating the method once every four weeks.
32. A method of reducing the incidence of flea allergy dermatitis in a dog weighing between 21 and 39 pounds by reducing blood feeding by ectoparasites on the dog by at least 80%, the method comprising:
(a) removing one 3.0 mL tube containing a composition comprising about 30% (w/w) cyphenothrin, about 2% (w/w) pyriproxyfen, and about 68% (w/w) diethylene glycol monoethyl ether from a package;
(b) opening the tube to form an open end of the tube;
(c) placing the open end of the tube onto the dog's skin; and
(d) squeezing the tube to apply the composition to the dog's skin.
33. A method of reducing the incidence of flea allergy dermatitis in a dog weighing between 40 and 60 pounds by reducing blood feeding by ectoparasites on the dog by at least 80%, the method comprising:
(a) removing one 4.5 mL tube containing a composition comprising about 30% (w/w) cyphenothrin, about 2% (w/w) pyriproxyfen, and about 68% (w/w) diethylene glycol monoethyl ether from a package;
(b) opening the tube to form an open end of the tube;
(c) placing the open end of the tube onto the dog's skin; and
(d) squeezing the tube to apply the composition to the dog's skin.
34. A method of reducing the incidence of flea allergy dermatitis in a dog weighing at least 61 pounds by reducing blood feeding by ectoparasites on the dog by at least 80%, the method comprising:
(a) removing one 6.0 mL tube containing a composition comprising about 30% (w/w) cyphenothrin, about 2% (w/w) pyriproxyfen, and about 68% (w/w) diethylene glycol monoethyl ether from a package;
(b) opening the tube to form an open end of the tube;
(c) placing the open end of the tube onto the dog's skin; and
(d) squeezing the tube to apply the composition to the dog's skin.