Method for treating an inflammation or lesion caused by a virus
View Patent ↗A method for treating an inflammation or lesion caused by herpes virus, comprising topically applying to said inflammation or lesion a composition comprising or consisting essentially of a C 1 to C 3 monohydroxy alcohol or a C 2 to C 4 diol and a sufficient amount of an acid to adjust the pH of the composition to below 4.6. Topical administration of the composition is preferred and is effective in treating lesions associated infections by viruses such as Herpes simplex. Nasal deliverable forms are effective in treating symptoms due to viruses that cause the common cold. Pharmaceutical compositions for use in the present method are provided.
1. A composition for inactivating an enveloped virus, wherein
the active components of said composition consist of a C1-C3 alcohol or a C2-C4 diol, where the concentration of said ethanol in said composition is between about 0.2% and 12.5% by volume, and a sufficient amount of an acid to adjust the pH of the composition to about 4.6 or less;
said composition further comprises a pharmaceutically acceptable carrier; and
said composition is suitable for administration to a canker sore or lesion on the skin surface and effective to kill or inactivate a virus upon such topical administration.
2. The composition of claim 1 , wherein said alcohol is selected from the group consisting of methanol, ethanol, 1-propanol, 2-propanol, 2,3-butanediol, 1,2-butanediol, 1,3-butanediol, and 1,4-butanediol.
3. The composition of claim 2 , wherein said alcohol is ethanol.
4. The composition of claim 1 , wherein said acid is an organic acid.
5. The composition of claim 4 , wherein said organic acid selected from the group consisting of glycolic acid, lactic acid, succinic acid, malic acid, citric acid and acetic acid.
6. The composition of claim 1 , wherein said acid is an inorganic acid.
7. The composition of claim 6 , wherein said acid is hydrochloric acid.
8. The composition of claim 1 , wherein the pH of said composition is 2.45.
9. The composition of claim 1 , wherein said virus is a member of the Herpesviridae family.
10. The composition of claim 9 , wherein said virus is selected from the group consisting of Herpes simplex 1, Herpes simplex 2, and Varicella zoster.
11. The composition of claim 1 , wherein said composition is a topical preparation selected from the group consisting of a tincture, gel, ointment, cream, salve, lotion, lip balm, foam.
12. The composition of claim 1 , wherein said composition comprises 10% by volume ethanol and 0.6% by weight glycolic acid.
13. The composition of claim 12 , wherein said composition is a topical preparation selected from the group consisting of a tincture, gel, ointment, cream, salve, lotion, lip balm, foam.