Agonists of GPR131 and uses thereof

1. A compound of Formula (I)

or a derivative thereof, wherein

A is H, —OH, halo, alkyl, alkoxy, aryl, arylalkyl, aryloxy, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

B is alkyl, alkenyl, or alkynyl, each of which may be optionally substituted, or B is —(CR a1 R a2 ) i O(CR a3 R a4 ) j —, —(CR a1 R a2 ) i C(O)(CR a3 R a4 ) j —, —(CR a1 R a2 ) i S(CR a3 R a4 ) j —, —(CR a1 R a2 ) i S(O)(CR a3 R a4 ) j —, —(CR a1 R a2 ) i S(O) 2 (CR a3 R a4 ) j —, —(CR a1 R a2 ) i N(R a5 )(CR a3 R a4 ) j —, —C(O)C(R a1 R a2 ) i S—, or absent;

D is H, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

E is —(CR b1 R b2 ) k O—, —(CR b1 R b2 ) k C(O)—, —(CR b1 R b2 ) k OC(O)—, —(CR b1 R b2 ) k S—, —(CR b1 R b2 ) k S(O)—, —(CR b1 R b2 ) k S(O) 2 —, —(CR b1 R b2 ) k N(R b3 )—, —(CR b1 R b2 ) k C(O)N(R b3 )—, —(CR b1 R b2 ) k S(O) 2 N(R b3 )—, or absent;

G is —(CR c1 R c2 ) m —, —C(O)—, or optionally substituted alkenyl;

L is H, —OH, halo, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

W is CR 1 or N;

each i, j, and k is independently 0, 1, or 2;

m is 1, 2, or 3;

each R a1 , R a2 , R a3 , R a4 , R a5 , R b1 , R b2 , R c1 , and R c2 is independently H, F, or optionally substituted alkyl;

R b3 is H or optionally substituted alkyl;

or R c1 and R b3 together with the atoms to which they are attached may form an optionally substituted heterocycloalkyl; and

each R 1 is independently H, halo, cyano, amino, or optionally substituted alkyl; with the proviso that if G is —(CR c1 R c2 ) m — wherein R c1 and R c2 are both —CH 3 and m is 1, then E is not absent.

2. A compound of claim 1 , wherein A is aryl or heteroaryl, each of which may be optionally substituted.

3. A compound of claim 1 , wherein A is an optionally substituted alkyl.

4. A compound of claim 1 , wherein B is —CH 2 CH 2 —, —CH 2 O—, —CH 2 S—, —CH 2 S(O)—, or —CH 2 S(O) 2 —.

5. A compound of claim 1 , wherein D is aryl or alkyl, each of which may be optionally substituted.

6. A compound of claim 1 , wherein E is —(CR b1 R b2 ) k C(O)N(R b3 )— and wherein R b3 is H or C 1-3 alkyl, and k is 0.

7. A compound of claim 1 , wherein G is —CH 2 —.

8. A compound of claim 1 , wherein L is aryl or heteroaryl, each of which may be optionally substituted.

9. A compound of claim 1 , wherein W is CR 1 wherein R 1 is H or C 1-3 alkyl.

10. A compound of claim 1 , wherein W is N.

11. A compound of claim 1 , wherein i is 1, j is 0, k is 0 or 1, and m is 1.

12. A compound of Formula (II)

or a derivate thereof, wherein

A is H, —OH, halo, alkyl, alkoxy, aryl, arylalkyl, aryloxy, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

B is alkyl, alkenyl, or alkynyl, each of which may be optionally substituted, or B is —(CR a1 R a2 ) i O(CR a3 R a4 ) j —, —(CR a1 R a2 ) i C(O)(CR a3 R a4 ) j —, —(CR a1 R a2 ) i S(CR a3 R a4 ) j —, —(CR a1 R a2 ) i S(O)(CR a3 R a4 ) j —, —(CR a1 R a2 ) i S(O) 2 (CR a3 R a4 ) j —, —(CR a1 R a2 ) i N(R a5 )(CR a3 R a4 ) j —, —C(O)C(R a1 R a2 ) i S—, or absent;

D is H, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

L is H, halo, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

W is CR 1 or N;

each i and j is independently 0, 1, or 2;

each R a1 , R a2 , R a3 , R a4 , R a5 , R b3 , R c1 , and R c2 is independently H or optionally substituted alkyl, or R c1 and R b3 together with the atoms to which they are attached may form an optionally substituted heterocycloalkyl; and

each R 1 is independently H, halo, or optionally substituted alkyl.

13. A compound of Formula (III)

or a derivate thereof, wherein

A is H, halo, alkyl, alkoxy, aryl, arylalkyl, aryloxy, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

L is H, halo, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted;

W is CR 1 or N;

each X is independently halo, cyano, sulfonamide, optionally substituted alkyl, —OR a , —NR a R b , —C(O)R a , —C(O)OR a , —C(O)NR a R b , —NR a C(O)R b , —SR a , —S(O)R a , —S(O) 2 R a , or —NR a S(O) 2 R b , wherein R a and R b are independently H or optionally substituted alkyl;

n is 0, 1, 2, 3, 4 or 5;

each R b3 , R c1 , and R c2 is independently H or optionally substituted alkyl, or R c1 and R b3 together with the atoms to which they are attached may form an optionally substituted heterocycloalkyl; and

each R 1 is independently H, halo, or optionally substituted alkyl.

14. A compound selected from the group consisting of

N-Benzyl-2-((2-chloro-6-fluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

1-(1,3-Dimethyl-1H-pyrazol-4-yl)-N-((1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazol-5-yl)methyl)-N-methylmethanamine;

1-(4-Fluorophenyl)-N-methyl-N-((3-methylpyridin-4-yl)methyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

4-((1-(4-Fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamido)methyl)-3-methylpyridine 1-oxide;

Ethyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylate;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(1,3-Dimethyl-1H-pyrazol-4-yl)-N-((1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)methyl)-N-methylmethanamine;

N-(3,4-Dimethoxybenzyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

(E)-N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(2,3,6-trifluorostyryl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)sulfonyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((2,3,6-trifluorophenyl)amino)methyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(2,3,6-trifluorophenyl)-1H-imidazole-5-carboxamide;

N-((1-Ethyl-3-methyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-N-((1,3,5-trimethyl-1H-pyrazol-4-yl)methyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-((1-methylpiperidiN-4-yl)methyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-N-ethyl-1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((methyl(2,3,6-trifluorophenyl)amino)methyl)-1H-imidazole-5-carboxamide;

N-((2,4-Dimethylthiazol-5-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(2,3,6-trifluorophenethyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-((1-methylpyrrolidiN-3-yl)methyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2-oxo-2-phenylethyl)thio)-1H-imidazole-5-carboxamide;

N-(1-(1,3-Dimethyl-1H-pyrazol-4-yl)ethyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)methyl)-N-1,3-trimethyl-1H-pyrazole-4-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-2-(2,3,6-trifluorophenethyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2-methyl-1-oxo-1-phenylpropan-2-yl)thio)-1H-imidazole-5-carboxamide;

4-(((1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)methoxy)methyl)pyridine;

1-(1,3-Dimethyl-1H-pyrazol-4-yl)-N-((1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)methyl)methanamine;

2-((2-Chloro-6-fluorobenzyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-2-(2-methyl-1-(2,3,6-trifluorophenyl)propan-2-yl)-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-fluorophenyl)-N,N-dimethyl-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)oxy)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorophenyl)ethynyl)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-(2-Fluorophenethyl)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

(2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl)(2-(pyridin-4-yl)pyrrolidin-1-yl)methanone;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-2-(2-(trifluoromethyl)phenethyl)-1H-imidazole-5-carboxamide;

(2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl)(2-(pyridin-4-yl)piperidin-1-yl)methanone;

tert-butyl 4-(((5-(((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)(methyl)carbamoyl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)methyl)-3,5-difluorobenzoate;

4-(((5-(((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)(methyl)carbamoyl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)methyl)-3,5-difluorobenzoic acid;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((3,3,3-trifluoro-2-oxopropyl)thio)-1H-imidazole-5-carboxamide;

2-((Cyclopropylmethyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(neopentylthio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-2-(isobutylthio)-N-methyl-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-2-((3,3-dimethyl-2-oxobutyl)thio)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

2-((2-Chlorobenzyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

2-((2-Chlorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-((2-methylpyridin-4-yl)methyl)-1H-imidazole-5-carboxamide;

2-((3-Chloropyridin-2-yl)methyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((5-methyl-1,2,4-oxadiazol-3-yl)methyl)thio)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-chlorophenyl)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-N-methyl-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-N-methyl-1-phenyl-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-N-methyl-1-phenyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-chlorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-N-methyl-N-(pyridin-4-ylmethyl)-1-(4-(trifluoromethyl)phenyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-ethylphenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-(4-methoxyphenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2,6-Dimethylbenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2,6-Dichlorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-2-((2-methylbenzyl)thio)-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-N-methyl-N-(pyridin-4-ylmethyl)-1-(p-tolyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-(3-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-1-cyclohexyl-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorobenzyl)thio)-N-methyl-1-neopentyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-(((2,6-Dichlorophenyl)thio)methyl)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorophenoxy)methyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((2,3,5,6-tetrafluorophenyl)thio)methyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2-(2,3,6-trifluorophenyl)propan-2-yl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((2,3,6-trifluorobenzyl)thio)methyl)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((2,3,6-trifluorobenzyl)sulfonyl)methyl)-1H-imidazole-5-carboxamide;

(E)-3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)prop-2-en-1-one;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)oxy)methyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-((2-methylpyridin-4-yl)methyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((2-Chloropyridin-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((pyridine-4-ylmethyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(methyl(2,3,6-trifluorobenzyl)amino)-1H-imidazole-5-carboxamide;

N-((4-Ethyl-2-methylthiazol-5-yl)methyl)-1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-((1-methyl-5-phenoxy-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carboxamide;

2-((3-Chloro-4-fluorophenethyl)thio)-1-(4-fluorophenyl)-N-((2-methylpyridin-4-yl)methyl)-1H-imidazole-5-carboxamide;

N-(4-(Dimethylamino)benzyl))-1-(4-fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-4-dimethyl-N-((2-methylpyridin-4-yl)methyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

2-((3-Chloro-4-fluorophenethyl)sulfonyl)-1-(4-fluorophenyl)-N-methyl-N-((2-methylpyridin-4-yl)methyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-2-((2,3,6-trifluorobenzyl)thio)-N-((2-trifluoromethyl)pyridin-4-yl)methyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluorophenethyl)sulfonyl)-1-(4-fluorophenyl)-N-methyl-N-((2-methylpyridin-4-yl)methyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-2-iodo-N-methyl-N-((2-methylpyridin-4-yl)methyl)-1H-imidazole-5-carboxamide;

2-Bromo-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamine;

(2-((6-Chloro-2-fluoro-3-methoxybenzyl)thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl)(2-(pyridin-4-yl)pyrrolidin-1-yl)methanone;

(2-(2-Fluorophenethyl)-1-(4-fluorophenyl)-1H-imidazol-5-yl)(2-(pyridin-4-yl)pyrrolidin-1-yl)methanone;

2-(Benzylthio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

5-((6-Chloro-2-fluoro-3-methoxybenzyl)thio)-4-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-4H-1,2,4-triazole-3-carboxamide;

5-((6-Chloro-2-fluoro-3-methylbenzyl)thio)-4-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-4H-1,2,4-triazole-3-carboxamide;

2-((6-Chloro-2-fluoro-3-methoxybenzyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

2-((6-Chloro-2-fluoro-3-methylbenzyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

3-((2-Chloro-6-fluorobenzyl)oxy)-5-((2-chloro-6-fluorobenzyl)thio)-4-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole;

4-(3-Chlorophenyl)-3-((2,4-dichlorobenzyl)thio)-5-((2,3-difluorobenzyl)oxy)-4H-1,2,4-triazole;

1-(4-Fluorophenyl)-N-methyl-N-((2-methylthiazol-5-yl)methyl)-2-((2,3,6-trifluorobenzyl)-sulfinyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-((4-methylthiophen-2-yl)methyl)-2-((2,3,6-trifluorobenzyl)-sulfinyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-((2-methylthiazol-5-yl)methyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-3-ylmethyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyrazin-2-ylmethyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyrazin-2-ylmethyl)-2-((2,3,6-trifluorobenzyl)sulfinyl)-1H-imidazole-5-carboxamide;

4-(((1-(4-Fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)methoxy)methyl)-pyridine;

2-((2-Fluoro-6-(trifluoromethyl)benzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((4-Fluoro-2-(trifluoromethyl)benzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((4-Chloro-2-(trifluoromethyl)benzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Fluoro-3-(trifluoromethyl)benzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2,5-Difluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((6-Chloro-2-fluoro-3-methoxybenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Fluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-2-((2-(trifluoromethyl)benzyl)thio)-1H-imidazole-5-carboxamide;

2-((2-Chloro-5-fluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((5-Chloro-2-fluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-3,6-difluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Chloro-4,5-difluorobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-2-((2,3,5-trifluorobenzyl)thio)-1H-imidazole-5-carboxamide;

2-((2-Chloro-6-fluoro-3-methylbenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-2-((3-(trifluoromethyl)benzyl)thio)-1H-imidazole-5-carboxamide;

2-((6-Chloro-2-fluoro-3-methylbenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((5-Chloro-2-(trifluoromethyl)benzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((2-Cyanobenzyl)thio)-1-(4-fluorophenyl)-N-methyl-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

1-(4-Fluorophenyl)-N-methyl-2-((5-methyl-2-(trifluoromethyl)benzyl)thio)-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((6-Chloro-2-fluoro-3-methoxybenzyl)thio)-N-ethyl-1-(4-fluorophenyl)-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

2-((6-Chloro-2-fluoro-3-methylbenzyl)thio)-N-ethyl-1-(4-fluorophenyl)-N-(pyridin-4-ylmethyl)-1H-imidazole-5-carboxamide;

4-((1-(1-(4-Fluorophenyl)-4-methyl-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)ethoxy)methyl)pyridine;

2-((Benzo[d]oxazol-2-ylmethyl)thio)-N-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-2-(((3-ethyl-1,2,4-oxadiazol-5-yl)methyl)thio)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-2-(((3-isopropylisoxazol-5-yl)methyl)thio)-N-methyl-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((pyrazolo[1,5-a]pyridin-2-ylmethyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((1-methyl-1H-pyrazol-3-yl)methyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((1-methyl-1H-1,2,4-triazol-3-yl)methyl)thio)-1H-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-((pyrimidin-2-ylmethyl)thio)-M-imidazole-5-carboxamide;

N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methyl-2-(((4-methylthiazol-2-yl)methyl)thio)-1H-imidazole-5-carboxamide; and

Ethyl 2-((5-(((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)carbamoyl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)acetate;

or a pharmaceutically acceptable salt thereof.

15. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

16. A pharmaceutical composition comprising an amount of a compound of claim 1 effective to modulate GPR131, and a pharmaceutically acceptable carrier.

17. A method of treating a subject suffering from or at risk of a disease or condition for which GPR131 modulation provides a therapeutic benefit, comprising administering to the subject an effective amount of a compound of claim 1 .

18. The method of claim 17 wherein the disease is type 2 diabetes.

19. A method of treating a subject suffering from or at risk of a disease or condition for which GPR131 modulation provides a therapeutic benefit, comprising the concomitant administration of a compound of claim 1 and a DPP IV inhibitor.

20. The method of claim 19 wherein the DPP IV inhibitor is sitagliptin or vildagliptin.