Partial peptide of lacritin
The invention provides a polypeptide containing an amino acid sequence, which is a particular partial sequence of lacritin and is characterized by gyro-modification of N-terminal glutamine. The polypeptide promotes adhesion between a cell and extracellular matrix and is stable in aqueous solution.
1. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO: 1.
2. A method of promoting corneal epithelial cell adhesion, comprising contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 1 .
3. A medicament comprising the polypeptide of claim 1 as an effective ingredient.
4. The medicament of claim 3 , which is aqueous liquid.
5. A method for the treatment of a corneal epithelium disorder in a patient in need thereof, which comprises administering an effective amount of the polypeptide of claim 1 , wherein the corneal epithelium disorder is dry eye or a disease associated with dry eye.