Granted Patent
B2
US 8,709,417 · App. 13/498,570 · Granted Apr 29, 2014
Combination immunotherapy for the treatment of cancer
Inventors:
James Allison (New York, NY); Padmanee Sharma (Bellaire, TX); Sergio A. Quezada (Berkhamsted, GB); Tihui Fu (Houston, TX)
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Abstract
Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-I, etc.) are demonstrated herein to be useful for the treatment of tumors.
Claims (6)
1. A method of treating cancer in a patient comprising administering to the patient simultaneously or sequentially a blocking anti-CLTA-4 antibody and an ICOS ligand (ICOS-L).
2. The method of claim 1 , wherein the ICOS ligand is soluble.
3. The method of claim 1 , wherein the ICOS ligand is expressed on the surface of a cell.
4. The method of claim 3 , wherein the cell is a tumor cell.
5. The method of claim 4 , wherein the tumor cell is irradiated.
6. The method of claim 4 , wherein the tumor cell was surgically removed from the patient.
Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 3, 2012
From: QUEZADA, SERGIO A.
To: MEMORIAL SLOAN-KETTERING CANCER CENTER
Reel/Frame 028554/0743 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 3, 2012
From: HOWARD HUGHES MEDICAL INSTITUTE
To: MEMORIAL SLOAN-KETTERING CANCER CENTER
Reel/Frame 028554/0749 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 3, 2012
From: ALLISON, JAMES P.
To: HOWARD HUGHES MEDICAL INSTITUTE
Reel/Frame 028554/0755 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 3, 2012
From: PADMANEE SHARMA, M.D., PH.D.; FU, TIHUI D. PH.D.
To: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 028554/0762 →
Continuity (2)
Provisional Application
61247438
· Sep 30, 2009