Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy
A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.
1. A dentifrice composition comprising in a single phase:
an orally acceptable vehicle;
a source of fluoride ions;
a source of stannous ions;
a source of zinc ions; and
at least one polyphosphate salt selected from the group consisting of inorganic polyphosphate salts which have equal to or less than three phosphorous atoms;
wherein
the dentifrice composition has a total water content of less than about 10% based on the weight of the composition; and
the vehicle comprises a thickening agent comprising, in combination, a cross-linked polyvinylpyrrolidone present in an amount of 0.75 to 1.25 wt % of the composition and xanthan gum present in an amount from about 0.2 to 0.3 wt % of the composition.
2. The composition of claim 1 , wherein the at least one polyphosphate is selected from the group consisting of an alkali metal salt of a pyrophosphate, an alkali metal salt of a tripolyphosphate, and mixtures thereof.
3. The composition of claim 2 , wherein the at least one polyphosphate is selected from the group consisting of tetrasodium pyrophosphate, sodium tripolyphosphate, and mixtures thereof.
4. The composition of claim 3 , wherein the at least one polyphosphate comprises a mixture of tetrasodium pyrophosphate and sodium tripolyphosphate.
5. The composition of claim 4 , wherein the mixture of tetrasodium pyrophosphate and sodium tripolyphosphate comprises tetrasodium pyrophosphate and sodium tripolyphosphate in about a 2:3 weight ratio.
6. The composition of claim 1 , wherein the at least one polyphosphate comprises from 1 to 10 wt % of the composition.
7. The composition of claim 6 , wherein the at least one polyphosphate comprises from 3 to 7 wt % of the composition.
8. The composition of claim 1 , wherein the source of fluoride ions and the source of stannous ions comprises stannous fluoride.
9. The composition of claim 1 , wherein the source of zinc ions comprises a zinc salt of an organic acid.
10. The composition of claim 9 , wherein the source of zinc ions comprises zinc citrate.
11. The composition of claim 1 , further comprising an aqueous buffer system for the source of stannous ions.
12. The composition of claim 11 , wherein the buffer system is adapted to chelate the stannous ions in the composition.
13. The composition of claim 12 , wherein the buffer system comprises at least one of an organic acid or an alkali metal salt thereof.
14. The composition of claim 13 , wherein the organic acid is citric acid.
15. The composition of claim 13 , wherein the buffer system comprises a mixture of citric acid and trisodium citrate.
16. The composition of claim 13 , wherein the buffer system comprises from 0.1 to 10 wt % of the composition.
17. The composition of claim 13 , wherein the buffer system is present, by weight, in an amount which is greater than the amount, by weight, of the source of stannous ions.
18. A method for the treatment and prevention of bacterial plaque accumulation or prevention of tooth erosion, comprising administering to the oral cavity the dentifrice composition according to claim 1 .