Polymers for reversing heparin-based anticoagulation
View Patent ↗Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.
1. A heparin binding polymer, the polymer comprising:
a first dendritic polyol; and
one or more cationic moieties attached to the first dendritic polyol,
wherein the polymer comprises the structure of Formula (I):
wherein L 1 is the first dendritic polyol, L 2 is a second dendritic polyol, L 3 is a third dendritic polyol, L 4 is a fourth dendritic polyol, and L 5 is a fifth dendritic polyol.
2. A heparin binding polymer, the polymer comprising:
a first dendritic polyol; and
one or more cationic moities attached to the first dendritic polyol,
wherein the polymer comprises the structure of Formula (II):
wherein L 1 is the first dendritic polyol and L 2 is a second dendritic polyol, and wherein L 3 is a third dendritic polyol, and L 4 is a fourth dendritic polyol.
3. The heparin binding polymer of claim 1 , wherein at least the first dendritic polyol comprises a polyether polyol, and wherein the polymer is immobilized on a support.
4. The heparin binding polymer of claim 1 , wherein the cationic moiety comprises Formula (VI):
and wherein the heparin binding polymer comprises an average of 4 to 100 cationic moieties.
5. The heparin binding polymer of claim 1 , further comprising a protective moiety covalently attached to the first dendritic polyol.
6. The heparin binding polymer of claim 5 , wherein the protective moiety comprises polyethylene glycol.
7. The heparin binding polymer of claim 6 , wherein the polymer has a polyethelene glycol content of about 75% by weight.
8. The heparin binding polymer of claim 1 , wherein the one or more cationic moieties comprises an amine group.
9. The heparin binding polymer of claim 8 , wherein the amine group is a tetra-amine group, hexa-amine group, or a deca-amine group.
10. The heparin binding polymer of claim 8 , wherein the amine group comprises a methylated amine.
11. The heparin binding polymer of claim 8 , wherein the amine group comprises a methylated tetra-amine group, a methylated hexa-amine group, or a methylated deca-amine group.
12. The heparin binding polymer of claim 1 , wherein the first dendritic polyol comprises a polyether polyol.
13. The heparin binding polymer of claim 12 , wherein the polyether polyol is hyperbranched.
14. The heparin binding polymer of claim 12 , wherein the polyether polyol has a degree of branching in the range of 0.05 to 0.95.
15. The heparin binding polymer of claim 14 , wherein the degree of branching in the range of 0.40-0.65.
16. The heparin binding polymer of claim 2 , wherein at least the first dendritic polyol comprises a polyether polyol, and wherein the polymer is immobilized on a support.
17. The heparin binding polymer of claim 2 , wherein the cationic moiety comprises Formula (VI):
and wherein the heparin binding polymer comprises an average of 4 to 100 cationic moieties.
18. The heparin binding polymer of claim 2 , further comprising a protective moiety covalently attached to the first dendritic polyol.
19. The heparin binding polymer of claim 18 , wherein the protective moiety comprises polyethylene glycol.
20. The heparin binding polymer of claim 19 , wherein the polymer has a polyethelene glycol content of about 75% by weight.
21. The heparin binding polymer of claim 2 , wherein the one or more cationic moieties comprises an amine group.
22. The heparin binding polymer of claim 21 , wherein the amine group is a tetra-amine group, hexa-amine group, or a deca-amine group.
23. The heparin binding polymer of claim 21 , wherein the amine group comprises a methylated amine.
24. The heparin binding polymer of claim 21 , wherein the amine group comprises a methylated tetra-amine group, a methylated hexa-amine group, or a methylated deca-amine group.
25. The heparin binding polymer of claim 2 , wherein the first dendritic polyol comprises a polyether polyol.
26. The heparin binding polymer of claim 25 , wherein the polyether polyol is hyperbranched.
27. The heparin binding polymer of claim 25 , wherein the polyether polyol has a degree of branching in the range of 0.05 to 0.95.
28. The heparin binding polymer of claim 27 , wherein the degree of branching in the range of 0.40-0.65.
29. The heparin binding polymer of claim 2 , wherein the heparin binding polymer binds to heparin selected from at least one of: unfractionated heparin (UFH), low molecular weight heparin (LMWH), ultra low molecular weight heparin (ULMWH), fondaparinux, idraparinux enoxaparin, dalteparin, tinzaparin, semuloparin, or heparinoid.
30. The heparin binding polymer of claim 29 , wherein the heparin binding polymer binds to fondaparinux.
31. The heparin binding polymer of claim 1 , wherein the heparin binding polymer binds to heparin selected from at least one of: unfractionated heparin (UFH), low molecular weight heparin (LMWH), ultra low molecular weight heparin (ULMWH), fondaparinux, idraparinux enoxaparin, dalteparin, tinzaparin, semuloparin, or heparinoid.
32. The heparin binding polymer of claim 31 , wherein the heparin binding polymer binds to fondaparinux.