Use of bethanechol for treatment of xerostomia

1. A method for treating xerostomia, wherein said method comprises buccal administration of bethanechol to a subject in need of such treatment, wherein the bethanechol is administered as a liquid solution containing between 2-25 mg of bethanechol in 0.1-1.0 ml of solution per administration, administered more than once each day, wherein the bethanechol is maintained in the buccal cavity for between 30 seconds-5 minutes and is then swallowed.

2. The method according to claim 1 , wherein the xerostomia is associated with head and neck cancer.

3. The method according to claim 1 , wherein the xerostomia is associated with drug treatment.

4. The method according to claim 1 , wherein the xerostomia is associated with cancer chemotherapy treatment.

5. The method according to claim 1 , wherein the xerostomia is associated with Sjogren's syndrome.

6. The method according to claim 1 , wherein the xerostomia is associated with late-stage cancer.

7. The method according to claim 1 , wherein the bethanechol is in the form of bethanechol chloride.

8. The method according to claim 1 , wherein the bethanechol is in the form of the S-enantiomer.

9. The method according to claim 1 , wherein the bethanechol is maintained in the buccal cavity from 1 to 3 minutes prior to being swallowed.

10. The method according to claim 9 , wherein the bethanechol is maintained in the buccal cavity for 2 minutes prior to being swallowed.