IP Library › Granted Patent US 9,352,041
Granted Patent B2
US 9,352,041 · App. 13/509,416 · Granted May 31, 2016

Use of an oleogel containing triterpene for healing wounds

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Quick Facts
Patent No.
US 9,352,041
App. No.
13/509,416
Granted
May 31, 2016
Kind
B2
Abstract

An oleogel comprising a non-polar liquid and a powder containing triterpene is provided as an oleogel that may be used for healing wounds.

Claims (15)

1. A method for treating epidermolysis bullosa in a patient in need thereof, comprising topically administering to an area of epidermolysis bullosa of the patient an oleogel, wherein the oleogel comprises betulin as an active substance in a powder form, and wherein the fraction of betulin in the powder is greater than 50 weight-percent.

2. The method of claim 1 , wherein the area of epidermolysis bullosa comprises blisters.

3. The method of claim 1 , wherein the powder comprises betulin and lupeol.

4. The method of claim 3 , wherein the joint fraction of betulin and lupeol in the powder is greater than 80 weight-percent.

5. The method of claim 3 , wherein the joint fraction of betulin and lupeol in the powder is greater than 85 weight-percent.

6. The method of claim 1 , wherein the oleogel further comprises a nonpolar liquid.

7. The method of claim 6 , wherein the nonpolar liquid comprises a fraction of between 80 weight-percent and 99 weight-percent in relation to the total weight of the oleogel, and wherein the powder comprises a fraction of between 1 weight-percent and 20 weight-percent in relation to the total weight of the oleogel.

8. The method of claim 6 , wherein the nonpolar liquid is a plant, animal, mineral, or synthetic oil.

9. The method of claim 8 , wherein the plant oil is a vegetable oil which is selected from one of the following: sunflower oil, olive oil, avocado oil, and almond oil.

10. The method of claim 1 , wherein the fraction of betulin in the powder is greater than 60 weight-percent.

11. The method of claim 1 , wherein a mean particle size of the powder is between 20 nm and 50 μm.

12. The method of claim 1 , wherein a mean particle size of the powder is less than 10 μm.

13. The method of claim 1 , wherein the oleogel includes an additional wound healing substance.

14. The method of claim 1 , wherein the powder further comprises betulinic acid, oleanolic acid, and erythrodiol.

15. The method of claim 1 , wherein the patient is a human.

Assignments (5)
MERGER Recorded Jan 12, 2024
From: AMRYT RESEARCH LIMITED
To: AMRYT PHARMACEUTICALS DESIGNATED ACTIVITY COMPANY
Reel/Frame 066110/0568 →
RELEASE OF SECURITY INTEREST Recorded Apr 13, 2023
From: ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
To: AMRYT GENETICS LIMITED; AMRYT PHARMACEUTICALS, INC.; AMRYT ENDO, INC.; AMRYT RESEARCH LIMITED
Reel/Frame 063318/0849 →
SECURITY INTEREST Recorded Feb 18, 2022
From: AMRYT RESEARCH LIMITED
To: ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
Reel/Frame 059049/0328 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2016
From: BIRKEN AG
To: AMRYT RESEARCH LIMITED
Reel/Frame 038700/0466 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2012
From: SCHEFFLER, ARMIN, DR.
To: BIRKEN AG
Reel/Frame 028255/0763 →