Fluorinated oxa or thia heteroarylalkylsulfide derivatives for combating invertebrate pests
View Patent ↗The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R 1 , R 2 , R 3U , X, n and p are defined as in the description.
1. A compound of formula I, or a salt or N-oxide thereof:
wherein
X is O or S(═O) m ;
m is 0, 1 or 2;
n is 0, 1 or 2;
p is 1 or 2
R 3U is C 1 -C 10 -haloalkyl, C 2 -C 6 -haloalkenyl, C 3 -C 6 -haloalkynyl, C 3 -C 6 -halocycloalkyl or C 3 -C 6 -halocycloalkenyl, wherein at least one halogen in said C 1 -C 10 -haloalkyl, C 2 -C 6 -haloalkenyl, C 3 -C 6 -haloalkynyl, C 3 -C 6 -halocycloalkyl or C 3 -C 6 -halocycloalkenyl is fluorine;
U is a 5- to 12-membered monocyclic or bicyclic heteroaromatic ring-system which may contain 1 to 4 heteroatoms selected from O, S and N, wherein the heteroaromatic ring may be substituted by one to four substituents V;
V is independently halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl which may be substituted with halogen atoms, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C(═O)R 4 , C(═S)R 4 , S(O) o R 10 , CN, NO 2 or an amino group which may be substituted or disubstituted by C 1 -C 4 -alkyl or by C 1 -C 4 -acyl;
o is 0, 1 or 2;
R 1 and R 2 are independently of each other selected from the group consisting of hydrogen, halogen, C 1 -C 6 -alkyl which may be substituted by halogen, by C 1 -C 4 -alkoxy, by C 1 -C 4 -alkylthio, by C 1 -C 4 -alkylsulfinyl, by C 1 -C 6 -alkylsulfonyl, by CN, by C(═O)R 4 , by OC(═O)R 4 , by N—(C 1 -C 3 -alkyl) 2 , or by OH, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl which may be substituted by one or more halogen atom(s), CN, C(═O)R 7 , C(═S)R 7 , C(R 11 )═NR 12 and C(R 11 )═N—OR 12 ,
or R 1 and R 2 may form together with the carbon atom whereto they are bonded C 3 -C 6 -cycloalkyl, C═C(R 5 )R 6 or C═N—OR 5 ;
R 4 is hydrogen, hydroxyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy or NR 8 R 9 ;
R 5 is hydrogen or C 1 -C 4 -alkyl;
R 6 is C 1 -C 6 -alkoxy or NR 8 R 9 ;
R 7 is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy which may be substituted by halogen, by C 1 -C 4 -alkoxy, by C 1 -C 4 -alkoxy-C 1 -C 4 -alkoxy, by C 1 -C 4 -alkylthio, by C 1 -C 4 -alkylsulfinyl, by C 1 -C 6 -alkylsulfonyl, by C 3 -C 6 -cycloalkyl, by tetrahydrofuryl, by phenyl, by pyridyl; wherein said phenyl or pyridyl may be substituted by halogen, by CN, by C(═O)OR 12 or by C(═O)NR 11 R 12 , C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyloxy which may be substituted by halogen, C 3 -C 6 -cycloalkylthio which may be substituted by halogen, NR 8 R 9 , C 1 -C 6 -alkylthio, N(R 13 )C(═O)N(R 14 )R 15 or the following groups W to W 5 :
R 8 and R 9 form together with the nitrogen atom to which they are attached an amino, or mono-(C 1 -C 6 -alkyl)amino or di-(C 1 -C 4 -alkyl)amino or a C 2 -C 5 -cyclic amino group;
R 11 , R 12 , R 13 , R 14 and R 15 are independently hydrogen or C 1 -C 6 -alkyl;
R 10 is C 1 -C 6 -alkyl which may be substituted by halogen, by C 1 -C 4 -alkoxy, by C 1 -C 4 -alkoxy-C 1 -C 4 -alkoxy, by S(O) 0 —C 1 -C 6 -alkyl, by phenyl or by tetrahydrofuryl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl or C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl which may be substituted with halogen atoms.
2. A compound according to claim 1 , wherein
U is a 5- to 10-membered monocyclic or bicyclic heteroaromatic ring-system selected from the group consisting of pyridine, pyrimidine, pyrazine, pyridazine, 1,3,5-triazine, quinoline, 1H-indole, 1H-benzoimidazole, benzothiazole, benzooxazole, benzofuran, benzothiophene, 1H-pyrrole, 1H-pyrazole, 1H-1,2,4-triazole, 1H-imidazole, 1H-1,2,3-triazole, 1H-tetrazole, thiophene, thiazole, 1,3,4-thiadiazole, furan, oxazole, isoxazole, 1,2,4-oxadiazole and 1,3,4-oxadiazole, wherein the heteroaromatic ring may be substituted by V;
p is 1;
X is S(═O) m with m being 0, 1 or 2; and
R 3U is C 1 -C 3 -fluoroalkyl.
3. A compound according to claim 1 wherein
U is a 5-membered heteroaromatic ring selected from the group consisting of 1H-pyrrole, 1H-pyrazole, 1H-1,2,4-triazole, 1H-imidazole, 1H-1,2,3-triazole, 1H-tetrazole, thiophene, thiazole, 1,3,4-thiadiazole, furan, oxazole, isoxazole, 1,2,4-oxadiazole and 1,3,4-oxadiazole, wherein the heteroaromatic ring is substituted by V;
p is 1
X is S(═O) m with m being 0 or 1; and
R 3U is C 1 -C 3 -fluoroalkyl.
4. A compound according to claim 1 , wherein:
U is a 5-membered heteroaromatic ring selected from the group consisting of 1H-pyrrole, 1H-pyrazole, 1H-1,2,4-triazole, 1H-imidazole, 1H-1,2,3-triazole, 1H-tetrazole, thiophene, thiazole, 1,3,4-thiadiazole, furan, oxazole, isoxazole, 1,2,4-oxadiazole and 1,3,4-oxadiazole, wherein the heteroaromatic ring is substituted by V; and R 1 and R 2 are independently from each other selected from the group consisting of H, C 1 -C 4 -alkyl, Cl, CN, C(O)—C 1 -C 4 -alkyl, C(O)—C 1 -C 4 -alkoxy, C(O)NH 2 , C(O)NHMe, C(O)NHEt, C(O)NMe 2 , C(O)NMeEt, C(O)NEt 2 , C(S)NH 2 , C(S)NHMe, C(S)NHEt, C(S)NMe 2 , C(S)NMeEt and C(S)NEt 2 .
5. A compound according to claim 1 , wherein:
U is a 5-membered heteroaromatic ring selected from the group consisting of 1H-pyrrole, 1H-pyrazole, 1H-1,2,4-triazole, 1H-imidazole, 1H-1,2,3-triazole, 1H-tetrazole, thiophene, thiazole, 1,3,4-thiadiazole, furan, oxazole, isoxazole, 1,2,4-oxadiazole and 1,3,4-oxadiazole; wherein the heteroaromatic ring is substituted by at least one of the groups selected from halogen, CN, tert-butyl and CF 3 .
6. A compound according to claim 1 , wherein:
U is a 5-membered heteroaromatic ring selected from the group consisting of 1H-pyrazole, 1H-1,2,4-triazole and 1,3,4-thiadiazole; wherein the heteroaromatic ring is substituted by one of the groups selected from Cl, CN, tert-butyl and CF 3 ;
R 1 is selected from the group consisting of H, CN, C(═O)-Me, C(═O)-Et, C(═O)—NH 2 , C(═O)—NMeH, C(═O)—NEtH, C(═O)—NMe 2 , C(═O)—NMeEt, C(═O)—NEt 2 , C(═S)—NH 2 , C(═S)—NMeH, C(═S)—NEtH, C(═S)—NMe 2 , C(═S)—NMeEt and C(═S)—NEt 2 ;
R 2 is selected from the group consisting of H, Cl, Me and Et;
p is 1;
X is S(═O) m with m being 0 or 1; and
R 3U is CF 3 or CHF 2 .
7. A compound of claim 1 , wherein:
U is 1,3,4-thiadiazole;
V is CF 3 or CF 2 CF 3 ;
R 1 is H, CN or CH 2 OH;
R 2 is C 1 -C 6 alkyl which may be substituted by halogen;
X is S(═O) m with m being 0 or 1;
R 3U is C 1 -C 3 -fluoroalkyl;
n is 1 or 2; and
p is 1.
8. A compound of claim 7 , wherein:
R 1 is H;
R 2 is methyl or ethyl;
R 3U is CF 3 ; and
n is 2.
9. A compound of claim 7 , wherein:
R 1 is CN or CH 2 OH;
R 2 is methyl;
X is S(═O) m with m being 0;
R 3U is CF 3 ; and
n is 2.
10. A compound according to claim 1 , of formula 1-xxxx, selected from Table 1:
TABLE 1
1-xxxx
Posi-
No.
tion
V
r
R 1
R 2
R 3U
n
1-01.
2
5-CF 3
0
H
H
CF 3
2
1-02.
2
5-CF 3
0
H
H
CF 2 H
2
1-03.
2
5-CF 3
0
CN
H
CF 3
2
1-04.
2
5-CF 3
0
CN
H
CF 2 H
2
1-05.
2
5-CF 3
0
COOMe
H
CF 3
2
1-06.
2
5-CF 3
0
COOMe
H
CF 2 H
2
1-07.
2
5-CF 3
0
COOEt
H
CF 3
2
1-08.
2
5-CF 3
0
COOEt
H
CF 2 H
2
1-09.
2
5-CF 3
0
COO—i-Pr
H
CF 3
2
1-010.
2
5-CF 3
0
COO—i-Pr
H
CF 2 H
2
1-011.
2
5-CF 3
0
COO—t-Bu
H
CF 3
2
1-012.
2
5-CF 3
0
COO—t-Bu
H
CF 2 H
2
1-013.
2
5-CF 3
0
CON(Me) 2
H
CF 3
2
1-014.
2
5-CF 3
0
CON(Me) 2
H
CF 2 H
2
1-015.
2
5-CF 3
0
H
CF 3
2
1-016.
2
5-CF 3
0
H
CF 2 H
2
1-017.
2
5-CF 3
0
COOMe
F
CF 3
2
1-018.
2
5-CF 3
0
COOMe
F
CF 2 H
2
1-019.
2
5-CF 3
0
COOMe
Cl
CF 3
2
1-020.
2
5-CF 3
0
COOMe
Cl
CF 2 H
2
1-021.
2
5-CF 3
0
COOMe
Me
CF 3
2
1-022.
2
5-CF 3
0
COOMe
Me
CF 2 H
2
1-023.
2
5-CF 3
0
Me
H
CF 3
2
1-024.
2
5-CF 3
0
Me
H
CF 2 H
2
1-025.
2
3-Cl—5-CF 3
0
H
H
CF 3
2
1-026.
2
3-Cl—5-CF 3
0
H
H
CF 2 H
2
1-027.
2
3-Cl—5-CF 3
0
CN
H
CF 3
2
1-028.
2
3-Cl—5-CF 3
0
CN
H
CF 2 H
2
1-029.
2
3-Cl—5-CF 3
0
COOMe
H
CF 3
2
1-030.
2
3-Cl—5-CF 3
0
COOMe
H
CF 2 H
2
1-031.
2
3-Cl—5-CF 3
0
COOEt
H
CF 3
2
1-032.
2
3-Cl—5-CF 3
0
COOEt
H
CF 2 H
2
1-033.
2
5-CN
0
H
H
CF 3
2
1-034.
2
5-CN
0
H
H
CF 2 H
2
1-035.
2
5-CN
0
CN
H
CF 3
2
1-036.
2
5-CN
0
CN
H
CF 2 H
2
1-037.
3
6-Cl
0
H
H
CF 3
0
1-038.
3
6-Cl
0
H
H
CF 2 H
0
1-039.
3
6-Cl
0
H
H
CF 3
1
1-040.
3
6-Cl
0
H
H
CF 2 H
1
1-041.
3
6-Cl
0
H
H
CF 3
2
1-042.
3
6-Cl
0
H
H
CF 2 H
2
1-043.
3
6-Cl
1
H
H
CF 3
2
1-044.
3
6-Cl
1
H
H
CF 2 H
2
1-045.
3
6-Cl
0
Me
H
CF 3
2
1-046.
3
6-Cl
0
Me
H
CF 2 H
2
1-047.
3
6-Cl
0
Me
Me
CF 3
2
1-048.
3
6-Cl
0
Me
Me
CF 2 H
2
1-049.
3
6-Cl
0
H
H
CF 3
0
1-050.
3
6-Cl
0
H
H
CF 2 H
0
1-051.
3
6-Cl
0
H
H
CF 3
1
1-052.
3
6-Cl
0
H
H
CF 2 H
1
1-053.
3
6-Cl
0
H
H
CF 3
2
1-054.
3
6-Cl
0
H
H
(CF 2 )CF 3
0
1-055.
3
6-Cl
0
H
H
(CF 2 )CF 3
1
1-056.
3
6-Cl
0
H
H
(CF 2 )CF 3
2
1-057 .
3
6-Cl
0
Me
H
(CF 2 )CF 3
2
1-058.
3
6-Cl
0
H
H
CF 2 H
2
1-059.
3
6-Cl
0
F
H
CF 3
2
1-060.
3
6-Cl
0
F
H
CF 2 H
2
1-061.
3
6-Cl
0
F
F
CF 3
2
1-062.
3
6-Cl
0
F
F
CF 2 H
2
1-063.
3
6-Cl
0
Cl
H
CF 3
2
1-064.
3
6-Cl
0
Cl
H
CF 2 H
2
1-065.
3
6-Cl
0
Cl
Cl
CF 3
2
1-066.
3
6-Cl
0
Cl
Cl
CF 2 H
2
1-067.
3
6-CF 3
0
H
H
CF 3
0
1-068.
3
6-CF 3
0
H
H
CF 2 H
0
1-069.
3
6-CF 3
0
H
H
CF 3
1
1-070.
3
6-CF 3
0
H
H
CF 2 H
1
1-071.
3
6-CF 3
0
H
H
CF 3
2
1-072.
3
6-CF 3
0
H
H
CF 2 H
2
1-073.
3
6-CF 3
0
Me
H
CF 3
2
1-074.
3
6-CF 3
0
Me
H
CF 2 H
2
1-075.
3
6-CF 3
0
Me
Me
CF 3
2
1-076.
3
6-CF 3
0
Me
Me
CF 2 H
2
1-077.
3
6-CF 3
0
Et
H
CF 3
2
1-078.
3
6-CF 3
0
Et
H
CF 2 H
2
1-079.
3
6-CF 3
0
i-Pr
H
CF 3
2
1-080.
3
6-CF 3
0
i-Pr
H
CF 2 H
2
1-081.
3
6-CF 3
0
Pr
H
CF 3
2
1-082.
3
6-CF 3
0
Pr
H
CF 2 H
2
1-083.
3
6-CF 3
0
s-Bu
H
CF 3
2
1-084.
3
6-CF 3
0
s-Bu
H
CF 2 H
2
1-085.
3
6-CF 3
0
i-Bu
H
CF 3
2
1-086.
3
6-CF 3
0
i-Bu
H
CF 2 H
2
1-087.
3
6-CF 3
0
Bu
H
CF 3
2
1-088.
3
6-CF 3
0
Bu
H
CF 2 H
2
1-089.
3
6-CF 3
0
CH 2 —c-Pr
H
CF 3
2
1-090.
3
6-CF 3
0
CH 2 —c-Pr
H
CF 2 H
2
1-091.
3
6-CF 3
0
CH 2 CH═CH 2
H
CF 3
2
1-092.
3
6-CF 3
0
CH 2 CH═CH 2
H
CF 2 H
2
1-093.
3
6-CF 3
0
CH 2 C═CH
H
CF 3
2
1-094.
3
6-CF 3
0
CH 2 C═CH
H
CF 2 H
2
1-095.
3
6-CF 3
0
COOMe
H
CF 3
2
1-096.
3
6-CF 3
0
COOMe
H
CF 2 H
2
1-097.
3
6-CF 3
0
F
H
CF 3
2
1-098.
3
6-CF 3
0
F
H
CF 2 H
2
1-099.
3
6-CF 3
0
F
F
CF 3
2
1-0100.
3
6-CF 3
0
F
F
CF 2 H
2
1-0101.
3
6-CF 3
0
Cl
H
CF 3
2
1-0102.
3
6-CF 3
0
Cl
H
CF 2 H
2
1-0103.
3
6-CF 3
0
Cl
Cl
CF 3
2
1-0104.
3
6-CF 3
0
Cl
Cl
CF 2 H
2
1-0105.
3
6-CF 3
0
H
H
CF 2 CF 3
0
1-0106.
3
6-CF 3
0
H
H
CF 2 CF 3
1
1-0107.
3
6-CF 3
0
H
H
CF 2 CF 3
2
1-0108.
3
6-OCH 2 CF 3
0
H
H
CF 3
0
1-0109.
3
6-OCH 2 CF 3
0
H
H
CF 2 H
0
1-0110.
3
6-OCH 2 CF 3
0
H
H
CF 3
1
1-0111.
3
6-OCH 2 CF 3
0
H
H
CF 2 H
1
1-0112.
3
6-OCH 2 CF 3
0
H
H
CF 3
2
1-0113.
3
6-OCH 2 CF 3
0
H
H
CF 2 H
2
1-0114.
3
6-C═CH
0
H
H
CF 3
0
1-0115.
3
6-C═CH
0
H
H
CF 2 H
0
1-0116.
3
6-C═CH
0
H
H
CF 3
1
1-0117.
3
6-C═CH
0
H
H
CF 2 H
1
1-0118.
3
6-C═CH
0
H
H
CF 3
2
1-0119.
3
6-C═CH
0
H
H
CF 2 H
2
1-0120.
3
6-C═CH
1
H
H
CF 3
2
1-0121.
3
6-C═CH
1
H
H
CF 2 H
2
1-0122.
3
6-SCF 3
0
H
H
CF 3
0
1-0123.
3
6-SCF 3
0
H
H
CF 2 H
1
1-0124.
3
6-SCF 3
0
H
H
CF 3
2
1-0125.
3
6-SCF 3
0
H
H
CF 2 H
2
1-0126.
3
6-SMe
0
H
H
CF 3
2
1-0127.
3
6-SMe
0
H
H
CF 2 H
2
1-0128.
3
6-SOMe
0
H
H
CF 3
2
1-0129.
3
6-SOMe
0
H
H
CF 2 H
2
1-0130.
3
6-SO 2 Me
0
H
H
CF 3
2
1-0131.
3
6-SO 2 Me
0
H
H
CF 2 H
2
1-0132.
4
2,6-(Cl) 2
0
H
H
CF 3
0
1-0133.
4
2,6-(Cl) 2
0
H
H
CF 2 H
0
1-0134.
4
2,6-(Cl) 2
0
H
H
CF 3
1
1-0135.
4
2,6-(Cl) 2
0
H
H
CF 2 H
1
1-0136.
4
2,6-(Cl) 2
0
H
H
CF 3
2
1-0137.
4
2,6-(Cl) 2
0
H
H
CF 2 H
2
1-0138.
4
2,6-(Cl) 2
0
Me
H
CF 3
2
1-0139.
4
2,6-(Cl) 2
0
Me
H
CF 2 H
2
1-0140.
4
2,3,5,6-(F) 4
0
H
H
CF 3
0
1-0141.
4
2,3,5,6-(F) 4
0
H
H
CF 2 H
0
1-0142.
4
2,3,5,6-(F) 4
0
H
H
CF 3
1
1-0143.
4
2,3,5,6-(F) 4
0
H
H
CF 2 H
1
1-0144.
4
2,3,5,6-(F) 4
0
H
H
CF 3
2
1-0145.
4
2,3,5,6-(F) 4
0
H
H
CF 2 H
2
wherein m is 0 or 1;
Position in Table 1 is the position on the pyridyl group which is substituted by the moiety
and
V, r, R 1 , R 2 , R 3U and n are defined in Table 1.
11. A compound according to claim 1 , of formula 2-xxxx, selected from Table 2:
TABLE 2
2-xxxx
No.
Position
V
R 1
R 2
R 3U
n
2-01.
2
4,6-(Cl) 2
H
H
CF 3
0
2-02.
2
4,6-(Cl) 2
H
H
CF 2 H
0
2-03.
2
4,6-(Cl) 2
H
H
CF 3
1
2-04.
2
4,6-(Cl) 2
H
H
CF 2 H
1
2-05.
2
4,6-(Cl) 2
H
H
CF 3
2
2-06.
2
4,6-(Cl) 2
H
H
CF 2 H
2
2-07.
2
4-CF 3
H
H
CF 3
2
2-08.
2
4-CF 3
H
H
CF 2 H
2
2-09.
2
4-CF 3
COOMe
H
CF 3
2
2-010.
2
4-CF 3
COOMe
H
CF 2 H
2
2-011.
2
4-CF 3
COOEt
H
CF 3
2
2-012.
2
4-CF 3
COOEt
H
CF 2 H
2
2-013.
2
4-CF 3
CN
H
CF 3
2
2-014.
2
4-CF 3
CN
H
CF 2 H
2
2-015.
4
2,6-(Cl) 2
H
H
CF 3
0
2-016.
4
2,6-(Cl) 2
H
H
CF 2 H
0
2-017.
4
2,6-(Cl) 2
H
H
CF 3
1
2-018.
4
2,6-(Cl) 2
H
H
CF 2 H
1
2-019.
4
2,6-(Cl) 2
H
H
CF 3
2
2-020.
4
2,6-(Cl) 2
H
H
CF 2 H
2
2-021.
4
2-CF 3
H
H
CF 3
2
2-022.
4
2-CF 3
H
H
CF 2 H
2
2-023.
4
2-CF 3
COOMe
H
CF 3
2
2-024.
4
2-CF 3
COOMe
H
CF 2 H
2
2-025.
4
2-CF 3
COOEt
H
CF 3
2
2-026.
4
2-CF 3
COOEt
H
CF 2 H
2
2-027.
4
2-CF 3
CN
H
CF 3
2
2-028.
4
2-CF 3
CN
H
CF 2 H
2
2-029.
4
6-CF 3
H
H
CF 3
2
2-030.
4
6-CF 3
H
H
CF 2 H
2
2-031.
4
6-CF 3
COOMe
H
CF 3
2
2-032.
4
6-CF 3
COOMe
H
CF 2 H
2
2-033.
4
6-CF 3
COOEt
H
CF 3
2
2-034.
4
6-CF 3
COOEt
H
CF 2 H
2
2-035.
4
6-CF 3
CN
H
CF 3
2
2-036.
4
6-CF 3
CN
H
CF 2 H
2
2-037.
5
2-CF 3
H
H
CF 3
0
2-038.
5
2-CF 3
H
H
CF 2 H
0
2-039.
5
2-CF 3
H
H
CF 3
1
2-040.
5
2-CF 3
H
H
CF 2 H
1
2-041.
5
2-CF 3
H
H
CF 3
2
2-042.
5
2-CF 3
H
H
CF 2 H
2
2-043.
5
2-CF 3
Me
H
CF 3
2
2.044.
5
2-CF 3
Me
H
CF 2 H
2
2-045.
5
2-CF 3
Me
Me
CF 3
2
2-046.
5
2-CF 3
Me
Me
CF 2 H
2
2-047.
5
2-CF 3
Et
H
CF 3
2
2-048.
5
2-CF 3
Et
H
CF 2 H
2
2-049.
5
2-CF 3
i-Pr
H
CF 3
2
2-050.
5
2-CF 3
i-Pr
H
CF 2 H
2
2-051.
5
2-CF 3
Pr
H
CF 3
2
2-052.
5
2-CF 3
Pr
H
CF 2 H
2
2-053.
5
2-CF 3
s-Bu
H
CF 3
2
2-054.
5
2-CF 3
s-Bu
H
CF 2 H
2
2-055.
5
2-CF 3
i-Bu
H
CF 3
2
2-056.
5
2-CF 3
i-Bu
H
CF 2 H
2
2-057.
5
2-CF 3
Bu
H
CF 3
2
2-058.
5
2-CF 3
Bu
H
CF 2 H
2
2-059.
5
2-CF 3
CH 2 -c-Pr
H
CF 3
2
2-060.
5
2-CF 3
CH 2 -c-Pr
H
CF 2 H
2
2-061.
5
2-CF 3
CH 2 CH═CH 2
H
CF 3
2
2-062.
5
2-CF 3
CH 2 CH═CH 2
H
CF 2 H
2
2-063.
5
2-CF 3
CH 2 CH═CH
H
CF 3
2
2-064.
5
2-CF 3
CH 2 CH═CH
H
CF 2 H
2
2-065.
5
2-CF 3
COOMe
H
CF 3
2
2-066.
5
2-CF 3
COOMe
H
CF 2 H
2
2-067.
5
2-CF 3
CONHEt
H
CF 3
2
2-068.
5
2-CF 3
CONHEt
H
CF 2 H
2
2-069.
5
2-CF 3
CSNHMe
H
CF 3
2
2-070.
5
2-CF 3
CSNHMe
H
CF 2 H
2
2-071.
5
2-CF 3
F
H
CF 3
2
2-072.
5
2-CF 3
F
H
CF 2 H
2
2-073.
5
2-CF 3
F
F
CF 3
2
2-074.
5
2-CF 3
F
F
CF 2 H
2
2-075.
5
2-CF 3
Cl
H
CF 3
2
2-076.
5
2-CF 3
Cl
H
CF 2 H
2
2-077.
5
2-CF 3
Cl
Cl
CF 3
2
2-078.
5
2-CF 3
Cl
Cl
CF 2 H
2
2-079.
5
2-CF 3
H
H
CF 2 CF 3
0
2-080.
5
2-CF 3
H
H
CF 2 CF 3
1
2-081.
5
2-CF 3
H
H
CF 2 CF 3
2
2-082.
5
2-CF 3 -4-Me
H
H
CF 3
0
2-083.
5
2-CF 3 -4-Me
H
H
CF 2 H
0
2-084.
5
2-CF 3 -4-Me
H
H
CF 3
1
2-085.
5
2-CF 3 -4-Me
H
H
CF 2 H
1
2-086.
5
2-CF 3 -4-Me
H
H
CF 3
2
2-087.
5
2-CF 3 -4-Me
H
H
CF 2 H
2
2-088.
5
2-CF 3 -4-Me
Me
H
CF 3
2
2-089.
5
2-CF 3 -4-Me
Me
H
CF 2 H
2
2-090.
5
2-SCF 3 -4-Me
H
H
CF 3
0
2-091.
5
2-SCF 3 -4-Me
H
H
CF 2 H
0
2-092.
5
2-SCF 3 -4-Me
H
H
CF 3
1
2-093.
5
2-SCF 3 -4-Me
H
H
CF 2 H
1
2-094.
5
2-SCF 3 -4-Me
H
H
CF 3
2
2-095.
5
2-SCF 3 -4-Me
H
H
CF 2 H
2
2-096.
5
2-SCF 3 -4-Me
Me
H
CF 3
2
2-097.
5
2-SCF 3 -4-Me
Me
H
CF 2 H
2
2-098.
5
2-c-Pr
H
H
CF 3
0
2-099.
5
2-c-Pr
H
H
CF 2 H
0
2-0100.
5
2-c-Pr
H
H
CF 3
1
2-0101.
5
2-c-Pr
H
H
CF 2 H
1
2-0102.
5
2-c-Pr
H
H
CF 3
2
2-0103.
5
2-c-Pr
H
H
CF 2 H
2
2-0104.
5
2-c-Pr
Me
H
CF 3
2
2-0105.
5
2-c-Pr
Me
H
CF 2 H
2
2-0106.
5
2-t-Bu
H
H
CF 3
0
2-0107.
5
2-t-Bu
H
H
CF 2 H
0
2-0108.
5
2-t-Bu
H
H
CF 3
1
2-0109.
5
2-t-Bu
H
H
CF 2 H
1
2-0110.
5
2-t-Bu
H
H
CF 3
2
2-0111.
5
2-t-Bu
H
H
CF 2 H
2
2-0112.
5
2-t-Bu
Me
H
CF 3
2
2-0113.
5
2-t-Bu
Me
H
CF 2 H
2
wherein m is 0 or 1;
Position in Table 2 is the position on the pyrimidyl group which is substituted by the moiety
and
V, R 1 , R 2 , R 3U and n are defined in Table 2.
12. A compound according to claim 1 , of formula 3-xxxx, selected from Table 3:
TABLE 3
3-xxxx
No.
Y 1
Y 2
Y 3
Y 4
R 1
R 2
R 3U
n
3-01.
C—H
N
C—H
C—Cl
H
H
CF 3
2
3-02.
C—H
N
C—H
C—Cl
H
H
CF 2 H
2
3-03.
C—H
N
C—H
C—Cl
COOMe
H
CF 3
2
3-04.
C—H
N
C—H
C—Cl
COOMe
H
CF 2 H
2
3-05.
C—H
N
C—H
C—Cl
COOMe
H
CF 3
2
3-06.
C—H
N
C—H
C—Cl
COOMe
H
CF 2 H
2
3-07.
C—H
N
C—H
C—Cl
CN
H
CF 3
2
3-08.
C—H
N
C—H
C—Cl
CN
H
CF 2 H
2
3-09.
C—Cl
N
C—CN
C—CN
H
H
CF 3
2
3-010.
C—Cl
N
C—CN
C—CN
H
H
CF 2 H
2
3-011.
C—Cl
N
C—CN
C—CN
COOMe
H
CF 3
2
3-012.
C—Cl
N
C—CN
C—CN
COOMe
H
CF 2 H
2
3-013.
C—Cl
N
C—CN
C—CN
COOEt
H
CF 3
2
3-014.
C—Cl
N
C—CN
C—CN
COOEt
H
CF 2 H
2
3-015.
C—Cl
N
C—CN
C—CN
CN
H
CF 3
2
3-016.
C—Cl
N
C—CN
C—CN
CN
H
CF 2 H
2
3-017.
C—H
N
C—CN
C—CN
H
H
CF 3
2
3-018.
C—H
N
C—CN
C—CN
H
H
CF 2 H
2
3-019.
C—H
N
C—CN
C—CN
COOMe
H
CF 3
2
3-020.
C—H
N
C—CN
C—CN
COOMe
H
CF 2 H
2
3-021.
C—H
N
C—CN
C—CN
COOEt
H
CF 3
2
3-022.
C—H
N
C—CN
C—CN
COOEt
H
CF 2 H
2
3-023.
C—H
N
C—CN
C—CN
CN
H
CF 3
2
3-024.
C—H
N
C—CN
C—CN
CN
H
CF 2 H
2
3-025.
C—H
C—H
C—Cl
N
H
H
CF 3
2
3-026.
C—H
C—H
C—Cl
N
H
H
CF 2 H
2
3-027.
C—H
C—H
C—Cl
N
COOMe
H
CF 3
2
3-028.
C—H
C—H
C—Cl
N
COOMe
H
CF 2 H
2
3-029.
C—H
C—H
C—Cl
N
COOEt
H
CF 3
2
3-030.
C—H
C—H
C—Cl
N
COOEt
H
CF 2 H
2
3-031.
C—H
C—H
C—Cl
N
CN
H
CF 3
2
3-032.
C—H
C—H
C—Cl
N
CN
H
CF 2 H
2
3-033.
C—H
C—H
C—CF 3
N
H
H
CF 3
2
3-034.
C—H
C—H
C—CF 3
N
H
H
CF 2 H
2
3-035.
C—H
C—H
C—CF 3
N
COOMe
H
CF 3
2
3-036.
C—H
C—H
C—CF 3
N
COOMe
H
CF 2 H
2
3-037.
C—H
C—H
C—CF 3
N
COOEt
H
CF 3
2
3-038.
C—H
C—H
C—CF 3
N
COOEt
H
CF 2 H
2
3-039.
C—H
C—H
C—CF 3
N
CN
H
CF 3
2
3-040.
C—H
C—H
C—CF 3
N
CN
H
CF 2 H
2
3-041.
N
C—Cl
N
C—Cl
H
H
CF 3
2
3-042.
N
C—Cl
N
C—Cl
H
H
CF 2 H
2
3-043.
N
C—Cl
N
C—Cl
COOMe
H
CF 3
2
3-044.
N
C—Cl
N
C—Cl
COOMe
H
CF 2 H
2
3-045.
N
C—Cl
N
C—Cl
COOEt
H
CF 3
2
3-046.
N
C—Cl
N
C—Cl
COOEt
H
CF 2 H
2
3-047.
N
C—Cl
N
C—Cl
CN
H
CF 3
2
3-048.
N
C—Cl
N
C—Cl
CN
H
CF 2 H
2
3-049.
N
C—OMe
N
C—OMe
H
H
CF 3
2
3-050.
N
C—OMe
N
C—OMe
H
H
CF 2 H
2
3-051.
N
C—OMe
N
C—OMe
COOMe
H
CF 3
2
3-052.
N
C—OMe
N
C—OMe
COOMe
H
CF 2 H
2
3-053.
N
C—OMe
N
C—OMe
COOEt
H
CF 3
2
3-054.
N
C—OMe
N
C—OMe
COOEt
H
CF 2 H
2
3-055.
N
C—OMe
N
C—OMe
CN
H
CF 3
2
3-056.
N
C—OMe
N
C—OMe
CN
H
CF 2 H
2
3-057.
C—H
C—H
C—CH═CH—CH═CH—C
H
H
CF 3
0
3-058.
C—H
C—H
C—CH═CH—CH═CH—C
H
H
CF 2 H
0
3-059.
C—H
C—H
C—CH═CH—CH═CH—C
H
H
CF 3
1
3-060.
C—H
C—H
C—CH═CH—CH═CH—C
H
H
CF 2 H
1
3-061.
C—H
C—H
C—CH═CH—CH═CH—C
H
H
CF 3
2
3-062.
C—H
C—H
C—CH═CH—CH═CH—C
H
H
CF 2 H
2
wherein m is 0 or 1; and
Y 1 , Y 2 , Y 3 , Y 4 , R 1 , R 2 , R 3U and n are defined in Table 3.
13. A compound according to claim 1 , of formula 7-xxxx, selected from Table 7:
TABLE 7
7-xxxx
No.
V
R 1
R 2
R 3U
n
7-01.
CF 3
H
H
CF 3
0
7-02.
CF 3
H
H
CF 3
1
7-03.
CF 3
H
H
CF 3
2
7-04.
CF 3
Me
H
CF 3
0
7-05.
CF 3
Me
H
CF 3
1
7-06.
CF 3
Me
H
CF 3
2
7-07.
CF 3
Me
Me
CF 3
2
7-08.
CF 3
Me
F
CF 3
2
7-09.
CF 3
Me
Cl
CF 3
2
7-10.
CF 3
Me
CH 2 OMe
CF 3
2
7-11.
CF 3
Me
CH 2 OH
CF 3
2
7-12.
CF 3
Me
CH 2 F
CF 3
2
7-13.
CF 3
Me
CH 2 N(Me) 2
CF 3
2
7-14.
CF 3
Me
CH 2 CN
CF 3
2
7-15.
CF 3
Et
H
CF 3
0
7-16.
CF 3
Et
H
CF 3
1
7-17.
CF 3
Et
H
CF 3
2
7-18.
CF 3
i-Pr
H
CF 3
0
7-19.
CF 3
i-Pr
H
CF 3
1
7-20.
CF 3
i-Pr
H
CF 3
2
7-21.
CF 3
Pr
H
CF 3
2
7-22.
CF 3
s-Bu
H
CF 3
2
7-23.
CF 3
i-Bu
H
CF 3
2
7-24.
CF 3
Bu
H
CF 3
2
7-25.
CF 3
CH 2 -c-Pr
H
CF 3
2
7-26.
CF 3
CH 2 CH═CH 2
H
CF 3
2
7-27.
CF 3
CH 2 CH═CH 2
CH 2 CH═CH 2
CF 3
2
7-28.
CF 3
CH 2 CH═CH
H
CF 3
2
7-29.
CF 3
CH 2 CH═CH
CH 2 C═CH
CF 3
2
7-30.
CF 3
COOMe
H
CF 3
2
7-31.
CF 3
COOMe
Me
CF 3
2
7-32.
CF 3
COOMe
F
CF 3
2
7-33.
CF 3
COOMe
Cl
CF 3
2
7-34.
CF 3
COOEt
H
CF 3
2
7-35.
CF 3
CN
H
CF 3
2
7-36.
CF 3
CHO
H
CF 3
2
7-37.
CF 3
Ac
H
CF 3
2
7-38.
CF 3
COEt
H
CF 3
2
7-39.
CF 3
CO-i-Pr
H
CF 3
2
7-40.
CF 3
COCH 2 Cl
H
CF 3
2
7-41.
CF 3
CON(Me) 2
H
CF 3
2
7-42.
CF 3
F
H
CF 3
2
7-43.
CF 3
F
F
CF 3
2
7-44.
CF 3
Cl
H
CF 3
2
7-45.
CF 3
Cl
Cl
CF 3
2
7-46.
CF 3
═CH—OMe
CF 3
2
7-47.
CF 3
═CH—OEt
CF 3
2
7-48.
CF 3
═C(Me)—OEt
CF 3
2
7-49.
CF 3
═CH—N(Me) 2
CF 3
2
7-50.
CF 3
═N—OH
CF 3
0
7-51.
CF 3
═N—OMe
CF 3
0
7-52.
CF 3
═N—OMe
CF 3
1
7-53.
CF 3
═N—OMe
CF 3
2
7-54.
CF 3
═N—OEt
CF 3
0
7-55.
CF 3
═N—OEt
CF 3
1
7-56.
CF 3
═N—OEt
CF 3
2
7-57.
CF 2 CF 3
Me
H
CF 3
0
7-58.
CF 2 CF 3
Me
H
CF 3
1
7-59.
CF 2 CF 3
Me
H
CF 3
2
7-60.
CF(CF 3 ) 2
Me
H
CF 3
0
7-61.
CF(CF 3 ) 2
Me
H
CF 3
1
7-62.
CF(CF 3 ) 2
Me
H
CF 3
2
7-63.
C(Me)(CF 3 ) 2
Me
H
CF 3
0
7-64.
C(Me)(CF 3 ) 2
Me
H
CF 3
1
7-65.
C(Me)(CF 3 ) 2
Me
H
CF 3
2
7-66.
NH 2
Me
H
CF 3
0
7-67.
Cl
Me
H
CF 3
0
7-68.
Cl
Me
H
CF 3
1
7-69.
Cl
Me
H
CF 3
2
7-70.
Br
Me
H
CF 3
0
7-71.
Br
Me
H
CF 3
1
7-72.
Br
Me
H
CF 3
2
7-73.
I
Me
H
CF 3
0
7-74.
I
Me
H
CF 3
1
7-75.
I
Me
H
CF 3
2
7-76.
Me
Me
H
CF 3
0
7-77.
Me
Me
H
CF 3
1
7-78.
Me
Me
H
CF 3
2
7-79.
Et
Me
H
CF 3
0
7-80.
Et
Me
H
CF 3
1
7-81.
Et
Me
H
CF 3
2
7-82.
i-Pr
Me
H
CF 3
0
7-83.
i-Pr
Me
H
CF 3
1
7-84.
i-Pr
Me
H
CF 3
2
7-85.
c-Pr
Me
H
CF 3
0
7-86.
c-Pr
Me
H
CF 3
1
7-87.
c-Pr
Me
H
CF 3
2
7-88.
t-Bu
Me
H
CF 3
0
7-89.
t-Bu
Me
H
CF 3
1
7-90.
t-Bu
Me
H
CF 3
2
7-91.
CF 3
Cl
H
CF 3
0
7-92.
CF 3
Cl
H
CF 3
1
7-93.
CF 3
COO-t-Bu
H
CF 3
2
7-94.
CF 3
CH 2 Cl
Cl
CF 3
0
7-95.
CF 3
Me
CH 2 OH
CF 3
0
7-96.
CF 3
Me
CH 2 OH
CF 3
1
7-97.
CF 3
Et
CH 2 OH
CF 3
0
7-98.
CF 3
Et
CH 2 OH
CF 3
1
7-99.
CF 3
Et
CH 2 OH
CF 3
2
7-100.
CF 3
Et
CH 2 OMe
CF 3
2
7-101.
CF 3
Et
F
CF 3
2
7-102.
CF 3
Et
Cl
CF 3
2
7-103.
CF 3
Et
CH 2 F
CF 3
2
wherein m is 0 or 1;
V, R 1 , R 2 , and n are defined in Table 7; and
R 3U is CF 2 H or CF 3 .
14. A compound according to claim 1 , of formula 8-xxxx, selected from Table 8:
TABLE 8
8-xxxx
No.
Y 1
Y 2
Y 3
Y 4
R 1
R 2
R 3U
n
8-01.
C—H
C—NO 2
C—H
C—H
H
H
CF 3
0
8-02.
C—H
C—NO 2
C—H
C—H
H
H
CF 3
1
8-03.
C—H
C—NO 2
C—H
C—H
H
H
CF 3
2
8-04.
C—Me
C—Ac
C—Me
C—H
H
H
CF 3
0
8-05.
C—Me
C—Ac
C—Me
C—H
H
H
CF 3
1
8-06.
C—Me
C—Ac
C—Me
C—H
H
H
CF 3
2
8-07.
C—H
N
C—CF 3
C—H
H
H
CF 3
0
8-08.
C—H
N
C—CF 3
C—H
H
H
CF 3
1
8-09.
C—H
N
C—CF 3
C—H
H
H
CF 3
2
8-010.
C—H
N
C—CF 3
C—H
Me
H
CF 3
0
8-011.
C—H
N
C—CF 3
C—H
Me
H
CF 3
1
8-012.
C—H
N
C—CF 3
C—H
Me
H
CF 3
2
8-013.
C—H
N
C—CF 3
C—H
Et
H
CF 3
0
8-014.
C—H
N
C—CF 3
C—H
Et
H
CF 3
1
8-015.
C—H
N
C—CF 3
C—H
Et
H
CF 3
2
8 016.
C—H
N
C—CF 3
C—H
i-Pr
H
CF 3
0
8-017.
C—H
N
C—CF 3
C—H
i-Pr
H
CF 3
1
8-018.
C—H
N
C—CF 3
C—H
i-Pr
H
CF 3
2
8-019.
C—H
N
C—CF 3
C—H
c-Pr
H
CF 3
0
8-020.
C—H
N
C—CF 3
C—H
c-Pr
H
CF 3
1
8-021.
C—H
N
C—CF 3
C—H
c-Pr
H
CF 3
2
8-022.
C—H
N
C—CF 3
C—H
Pr
H
CF 3
0
8-023.
C—H
N
C—CF 3
C—H
Pr
H
CF 3
1
8-024.
C—H
N
C—CF 3
C—H
Pr
H
CF 3
2
8-025.
C—H
N
C—CF 3
C—H
s-Bu
H
CF 3
0
8-026.
C—H
N
C—CF 3
C—H
s-Bu
H
CF 3
1
8-027.
C—H
N
C—CF 3
C—H
s-Bu
H
CF 3
2
8-028.
C—H
N
C—CF 3
C—H
i-Bu
H
CF 3
0
8-029.
C—H
N
C—CF 3
C—H
i-Bu
H
CF 3
1
8-030.
C—H
N
C—CF 3
C—H
i-Bu
H
CF 3
2
8-031.
C—H
N
C—CF 3
C—H
Bu
H
CF 3
0
8-032.
C—H
N
C—CF 3
C—H
Bu
H
CF 3
1
8-033.
C—H
N
C—CF 3
C—H
Bu
H
CF 3
2
8-034.
C—H
N
C—CF 3
C—H
2-Pen
H
CF 3
0
8-035.
C—H
N
C—CF 3
C—H
2-Pen
H
CF 3
1
8-036.
C—H
N
C—CF 3
C—H
2-Pen
H
CF 3
2
8-037.
C—H
N
C—CF 3
C—H
3-Pen
H
CF 3
0
8-038.
C—H
N
C—CF 3
C—H
3-Pen
H
CF 3
1
8-039.
C—H
N
C—CF 3
C—H
3-Pen
H
CF 3
2
8-040.
C—H
N
C—CF 3
C—H
c-Pen
H
CF 3
0
8-041.
C—H
N
C—CF 3
C—H
c-Pen
H
CF 3
1
8-042.
C—H
N
C—CF 3
C—H
c-Pen
H
CF 3
2
8-043.
C—H
N
C—CF 3
C—H
c-Hex
H
CF 3
0
8-044.
C—H
N
C—CF 3
C—H
c-Hex
H
CF 3
1
8-045.
C—H
N
C—CF 3
C—H
c-Hex
H
CF 3
2
8-046.
C—H
N
C—CF 3
C—H
CN
H
CF 3
0
8-047.
C—H
N
C—CF 3
C—H
CN
H
CF 3
1
8-048.
C—H
N
C—CF 3
C—H
CN
H
CF 3
2
8-049.
C—H
N
C—CF 3
C—H
COOMe
H
CF 3
0
8-050.
C—H
N
C—CF 3
C—H
COOMe
H
CF 3
1
8-051.
C—H
N
C—CF 3
C—H
COOMe
H
CF 3
2
8-052.
C—H
N
C—CF 3
C—H
COOEt
H
CF 3
0
8-053.
C—H
N
C—CF 3
C—H
COOEt
H
CF 3
1
8-054.
C—H
N
C—CF 3
C—H
COOEt
H
CF 3
2
8-055.
N
N
C—CF 3
C—H
H
H
CF 3
0
8-056.
N
N
C—CF 3
C—H
H
H
CF 3
1
8-057.
N
N
C—CF 3
C—H
H
H
CF 3
2
8-058.
N
N
C—CF 3
N
H
H
CF 3
0
8-059.
N
N
C—CF 3
N
H
H
CF 3
1
8-060.
N
N
C—CF 3
N
H
H
CF 3
2
8-061.
N
N
C—CF 3
N
Me
H
CF 3
0
8-062.
N
N
C—CF 3
N
Me
H
CF 3
1
8-063.
N
N
C—CF 3
N
Me
H
CF 3
2
8-064.
N
N
C—CF 3
N
Et
H
CF 3
0
8-065.
N
N
C—CF 3
N
Et
H
CF 3
1
8-066.
N
N
C—CF 3
N
Et
H
CF 3
2
8-067.
N
N
C—CF 3
N
i-Pr
H
CF 3
0
8-068.
N
N
C—CF 3
N
i-Pr
H
CF 3
1
8-069.
N
N
C—CF 3
N
i-Pr
H
CF 3
2
8-070.
N
N
C—CF 3
N
c-Pr
H
CF 3
0
8-071.
N
N
C—CF 3
N
c-Pr
H
CF 3
1
8-072.
N
N
C—CF 3
N
c-Pr
H
CF 3
2
8-073.
N
N
C—CF 3
N
Pr
H
CF 3
0
8-074.
N
N
C—CF 3
N
Pr
H
CF 3
1
8-075.
N
N
C—CF 3
N
Pr
H
CF 3
2
8-076.
N
N
C—CF 3
N
s-Bu
H
CF 3
0
8-077.
N
N
C—CF 3
N
s-Bu
H
CF 3
1
8-078.
N
N
C—CF 3
N
s-Bu
H
CF 3
2
8-079.
N
N
C—CF 3
N
i-Bu
H
CF 3
0
8-080.
N
N
C—CF 3
N
i-Bu
H
CF 3
1
8-081.
N
N
C—CF 3
N
i-Bu
H
CF 3
2
8-082.
N
N
C—CF 3
N
Bu
H
CF 3
0
8-083.
N
N
C—CF 3
N
Bu
H
CF 3
1
8-084.
N
N
C—CF 3
N
Bu
H
CF 3
2
8-085.
N
N
C—CF 3
N
2-Pen
H
CF 3
0
8-086.
N
N
C—CF 3
N
2-Pen
H
CF 3
1
8-087.
N
N
C—CF 3
N
2-Pen
H
CF 3
2
8-088.
N
N
C—CF 3
N
3-Pen
H
CF 3
0
8-089.
N
N
C—CF 3
N
3-Pen
H
CF 3
1
8-090.
N
N
C—CF 3
N
3-Pen
H
CF 3
2
8-091.
N
N
C—CF 3
N
c-Pen
H
CF 3
0
8-092.
N
N
C—CF 3
N
c-Pen
H
CF 3
1
8-093.
N
N
C—CF 3
N
c-Pen
H
CF 3
2
8-094.
N
N
C—CF 3
N
c-Hex
H
CF 3
0
8-095.
N
N
C—CF 3
N
c-Hex
H
CF 3
1
8-096.
N
N
C—CF 3
N
c-Hex
H
CF 3
2
8-097.
N
N
C—CF 3
N
CN
H
CF 3
0
8-098.
N
N
C—CF 3
N
CN
H
CF 3
1
8-099.
N
N
C—CF 3
N
CN
H
CF 3
2
8-0100.
N
N
C—CF 3
N
CO 2 Me
H
CF 3
0
8-0101.
N
N
C—CF 3
N
CO 2 Me
H
CF 3
1
8-0102.
N
N
C—CF 3
N
CO 2 Me
H
CF 3
2
8-0103.
N
N
C—CF 3
N
CO 2 Et
H
CF 3
0
8-0104.
N
N
C—CF 3
N
CO 2 Et
H
CF 3
1
8-0105.
N
N
C—CF 3
N
CO 2 Et
H
CF 3
2
8-0106.
N
N
C—CF 3
C—H
CO 2 -t-Bu
H
CF 3
0
8-0107.
N
N
C—CF 3
C—H
CO 2 -t-Bu
H
CF 3
1
8-0108.
N
N
C—CF 3
C—H
CO 2 -t-Bu
H
CF 3
2
8-0109.
C—CF 3
N
C—Et
C—H
CO 2 Me
H
CF 3
2
8-0110.
C—H
N
C—H
C—CF 3
Me
H
CF 3
2
8-0111.
C—Me
N
C—CF 3
C—H
H
H
CF 3
0
8-0112.
C—Me
N
C—CF 3
C—H
H
H
CF 3
1
8-0113.
C—Me
N
C—CF 3
C—H
H
H
CF 3
2
8-0114.
C—CF 3
N
C-t-Bu
C—H
CO 2 -t-Bu
H
CF 3
0
8-0115.
C—CF 3
N
C-t-Bu
C—H
CO 2 -t-Bu
H
CF 3
1
8-0116.
C—CF 3
N
C-t-Bu
C—H
CO 2 -t-Bu
H
CF 3
2
8-0117.
C—H
N
C-t-Bu
C—H
CO 2 -t-Bu
Me
CF 3
0
8-0118.
C—H
N
C-t-Bu
C—H
CO 2 -t-Bu
Me
CF 3
1
8-0119.
C—H
N
C-t-Bu
C—H
CO 2 -t-Bu
Me
CF 3
2
8-0120.
C—H
C—NO 2
C—H
C—H
CO 2 -t-Bu
H
CF 3
0
8-0121.
C—H
C—NO 2
C—H
C—H
CO 2 -t-Bu
Me
CF 3
0
8-0122.
C—H
C—NO 2
C—H
C—H
CO 2 -t-Bu
Me
CF 3
2
wherein m is 1 or 0;
Y 1 , Y 2 , Y 3 , Y 4 , R′, R 2 , and n are defined in Table 8; and
R 3U is CF 2 H or CF 3 .
15. A compound according to claim 1 , of formula 9-xxxx, selected from Table 9:
TABLE 9
9-xxxx
No.
Y 1
Y 2
Y 3
Y 4
R 1
R 2
R 3U
9-01.
O
C—CF 3
C—H
C—H
H
H
CF 3
9-02.
O
C—CF 3
C—H
C—H
H
H
CF 3
9-03.
O
C—CF 3
C—H
C—H
H
H
CF 3
9-04.
O
N
C—CF 3
C—H
H
H
CF 3
9-05.
O
N
C—CF 3
C—H
H
H
CF 3
9-06.
O
N
C—CF 3
C—H
H
H
CF 3
9-07.
O
C—CF 3
N
N
H
H
CF 3
9-08.
O
C—CF 3
N
N
H
H
CF 3
9-09.
O
C—CF 3
N
N
H
H
CF 3
9-010.
O
N
C—CF 3
N
H
H
CF 3
9-011.
O
N
C—CF 3
N
H
H
CF 3
9-012.
O
N
C—CF 3
N
H
H
CF 3
9-013.
O
C—CF 3
C—CN
N
H
H
CF 3
9-014.
O
C—CF 3
C—CN
N
H
H
CF 3
9-015.
O
C—CF 3
C—CN
N
H
H
CF 3
9-016.
S
C—Cl
C—H
C—H
H
H
CF 3
9-017.
S
C—Cl
C—H
C—H
H
H
CF 3
9-018.
S
C—Cl
C—H
C—H
H
H
CF 3
9-019.
S
C—Cl
C—H
C—H
Me
H
CF 3
9-020.
S
C—Cl
C—H
C—H
Me
H
CF 3
9-021.
S
C—Cl
C—H
C—H
Me
H
CF 3
9-022.
S
C—H
C—H
C—H
COOMe
H
CF 3
9-023.
S
C—H
C—H
C—H
COOMe
H
CF 3
9-024.
S
C—H
C—H
C—H
COOMe
H
CF 3
9-025.
S
C—H
C—H
C—H
COOH
H
CF 3
9-026.
S
C—H
C—H
C—H
CON(Me) 2
H
CF 3
9-027.
O
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-028.
O
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-029.
O
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-030.
O
C—CH═CH—CH═CH—C
C—H
Me
H
CF 3
9-031.
O
C—CH═CH—CH═CH—C
C—H
Me
H
CF 3
9-032.
O
C—CH═CH—CH═CH—C
C—H
Me
H
CF 3
9-033.
S
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-034.
S
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-035.
S
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-036.
S
C—CH═CH—CH═CH—C
C—H
Me
H
CF 3
9-037.
S
C—CH═CH—CH═CH—C
C—H
Me
H
CF 3
9-038.
S
C—CH═CH—CH═CH—C
C—H
Me
H
CF 3
9-039.
N—H
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-040.
N—H
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-041.
N—H
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-042.
N—Me
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-043.
N—Me
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-044.
N—Me
C—CH═CH—CH═CH—C
C—H
H
H
CF 3
9-045.
O
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-046.
O
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-047.
O
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-048.
S
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-049.
S
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-050.
S
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-051.
S
C—CH═CH—CH═CH—C
N
Me
H
CF 3
9-052.
S
C—CH═CH—CH═CH—C
N
Me
H
CF 3
9-053.
S
C—CH═CH—CH═CH—C
N
Me
H
CF 3
9-054.
N—H
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-055.
N—H
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-056.
N—H
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-057.
N—Me
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-058.
N—Me
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-059.
N—Me
C—CH═CH—CH═CH—C
N
H
H
CF 3
9-060.
S
C—Cl
N
C—CF 3
H
H
CF 3
9-061.
S
C—Cl
N
C—CF 3
H
H
CF 3
9-062.
S
C—Cl
N
C—CF 3
H
H
CF 3
9-063.
O
C—CH═CH—CH═CH—C
N
Me
H
CF 3
9-064.
O
C—CH═CH—CH═CH—C
N
Me
H
CF 3
9-065.
O
C—CH═CH—CH═CH—C
N
Me
H
CF 3
9-066.
O
N
C—CF 3
C—H
Me
H
CF 3
9-067.
O
N
C—CF 3
C—H
Me
H
CF 3
9-068.
O
N
C—CF 3
C—H
Me
H
CF 3
9-069.
O
N
C-t-Bu
C—H
Me
H
CF 3
9-070.
O
N
C-t-Bu
C—H
Me
H
CF 3
9-071.
O
N
C-t-Bu
C—H
Me
H
CF 3
9-072.
O
C—CH═CF—CH═CH—C
N
Me
H
CF 3
9-073.
O
C—CH═CF—CH═CH—C
N
Me
H
CF 3
9-074.
O
C—CH═CF—CH═CH—C
N
Me
H
CF 3
9-075.
O
C—CH═CH—CF═CH—C
N
Me
H
CF 3
9-076.
O
C—CH═CH—CF═CH—C
N
Me
H
CF 3
9-077.
O
C—CH═CH—CF═CH—C
N
Me
H
CF 3
9-078.
O
C—CH═CH—C(CF 3 )═CH—C
N
Me
H
CF 3
9-079.
O
C—CH═CH—C(CF 3 )═CH—C
N
Me
H
CF 3
9-080.
O
C—CH═CH—C(CF 3 )═CH—C
N
Me
H
CF 3
9-081.
O
C—CF═CF—CF═CF—C
N
Me
H
CF 3
9-082.
O
C—CF═CF—CF═CF—C
N
Me
H
CF 3
9-083.
O
C—CF═CF—CF═CF—C
N
Me
H
CF 3
9-084.
N
O
C—CF 3
C—H
H
H
CF 3
9-085.
N
O
C—CF 3
C—H
H
H
CF 3
9-086.
N
O
C—CF 3
C—H
H
H
CF 3
9-087.
N
O
C—CF 3
C—H
Me
H
CF 3
9-088.
C—H
O
C—Cl
N
H
H
CF 3
9-089.
C—H
O
C—Cl
N
H
H
CF 3
9-090.
C—H
O
C—Cl
N
H
H
CF 3
9-091.
C—H
O
C—Cl
N
Me
H
CF 3
9-092.
C—Cl
S
C—Cl
C—H
Me
H
CF 3
9-093.
C—Cl
S
C—Cl
C—H
Me
H
CF 3
9-094.
C—Cl
S
C—Cl
C—H
Me
H
CF 3
9-095.
C—H
N-t-Bu
N
N
H
H
CF 3
9-096.
C—H
N-t-Bu
N
N
H
H
CF 3
9-097.
C—H
N-t-Bu
N
N
H
H
CF 3
9-098.
N
N—CH═CH 2
N
N
H
H
CF 3
9-099.
N
N—CH═CH 2
N
N
H
H
CF 3
9-0100.
N
N—CH═CH 2
N
N
H
H
CF 3
9-0101.
N
O
C—CF 3
C—H
Me
H
CF 3
9-0102.
N
O
C—CF 3
C—H
Me
H
CF 3
wherein m is 1 or 0;
n is 0, 1, or 2;
Y 1 , Y 2 , Y 3 , Y 4 , R 1 , and R 2 are defined in Table 9; and
R 3U is CF 2 H or CF 3 .
16. A compound of formula 4-xxxx, selected from Table 4:
TABLE 4
4-xxxx
No.
Position
V
R 1
R 2
R 3U
n
4-01.
1
3-CF 3
H
H
CF 3
0
4-02.
1
3-CF 3
H
H
CF 2 H
0
4-03.
1
3-CF 3
H
H
CF 3
1
4-04.
1
3-CF 3
H
H
CF 2 H
1
4-05.
1
3-CF 3
H
H
CF 3
2
4-06.
1
3-CF 3
H
H
CF 2 H
2
4-07.
1
3-CF 3
Me
H
CF 3
0
4-08.
1
3-CF 3
Me
H
CF 2 H
0
4-09.
1
3-CF 3
Me
H
CF 3
1
4-010.
1
3-CF 3
Me
H
CF 2 H
1
4-011.
1
3-CF 3
Me
H
CF 3
2
4-012.
1
3-CF 3
Me
H
CF 2 H
2
4-013.
1
3-CF 3
Et
H
CF 3
0
4-014.
1
3-CF 3
Et
H
CF 2 H
0
4-015.
1
3-CF 3
Et
H
CF 3
1
4-016.
1
3-CF 3
Et
H
CF 2 H
1
4-017.
1
3-CF 3
Et
H
CF 3
2
4-018.
1
3-CF 3
Et
H
CF 2 H
2
4-019.
1
3-CF 3
i-Pr
H
CF 3
0
4-020.
1
3-CF 3
i-Pr
H
CF 2 H
0
4-021.
1
3-CF 3
i-Pr
H
CF 3
1
4-022.
1
3-CF 3
i-Pr
H
CF 2 H
1
4-023.
1
3-CF 3
i-Pr
H
CF 3
2
4-024.
1
3-CF 3
i-Pr
H
CF 2 H
2
4-025.
1
3-CF 3
c-Pr
H
CF 3
0
4-026.
1
3-CF 3
c-Pr
H
CF 2 H
0
4-027.
1
3-CF 3
c-Pr
H
CF 3
1
4-028.
1
3-CF 3
c-Pr
H
CF 2 H
1
4-029.
1
3-CF 3
c-Pr
H
CF 3
2
4-030.
1
3-CF 3
c-Pr
H
CF 2 H
2
4-031.
1
3-CF 3
Pr
H
CF 3
0
4-032.
1
3-CF 3
Pr
H
CF 2 H
0
4-033.
1
3-CF 3
Pr
H
CF 3
1
4-034.
1
3-CF 3
Pr
H
CF 2 H
1
4-035.
1
3-CF 3
Pr
H
CF 3
2
4-036.
1
3-CF 3
Pr
H
CF 2 H
2
4-037.
1
3-CF 3
s-Bu
H
CF 3
0
4-038.
1
3-CF 3
s-Bu
H
CF 2 H
0
4-039.
1
3-CF 3
s-Bu
H
CF 3
1
4-040.
1
3-CF 3
s-Bu
H
CF 2 H
1
4-041.
1
3-CF 3
s-Bu
H
CF 3
2
4-042.
1
3-CF 3
s-Bu
H
CF 2 H
2
4-043.
1
3-CF 3
i-Bu
H
CF 3
0
4-044.
1
3-CF 3
i-Bu
H
CF 2 H
0
4-045.
1
3-CF 3
i-Bu
H
CF 3
1
4-046.
1
3-CF 3
i-Bu
H
CF 2 H
1
4-047.
1
3-CF 3
i-Bu
H
CF 3
2
4-048.
1
3-CF 3
i-Bu
H
CF 2 H
2
4-049.
1
3-CF 3
Bu
H
CF 3
0
4-050.
1
3-CF 3
Bu
H
CF 2 H
0
4-051.
1
3-CF 3
Bu
H
CF 3
1
4-052.
1
3-CF 3
Bu
H
CF 2 H
1
4-053.
1
3-CF 3
Bu
H
CF 3
2
4-054.
1
3-CF 3
Bu
H
CF 2 H
2
4-055.
1
3-CF 3
2-Pen
H
CF 3
0
4-056.
1
3-CF 3
2-Pen
H
CF 2 H
0
4-057.
1
3-CF 3
2-Pen
H
CF 3
1
4-058.
1
3-CF 3
2-Pen
H
CF 2 H
1
4-059.
1
3-CF 3
2-Pen
H
CF 3
2
4-060.
1
3-CF 3
2-Pen
H
CF 2 H
2
4-061.
1
3-CF 3
3-Pen
H
CF 3
0
4-062.
1
3-CF 3
3-Pen
H
CF 2 H
0
4-063.
1
3-CF 3
3-Pen
H
CF 3
1
4-064.
1
3-CF 3
3-Pen
H
CF 2 H
1
4-065.
1
3-CF 3
3-Pen
H
CF 3
2
4-066.
1
3-CF 3
3-Pen
H
CF 2 H
2
4-067.
1
3-CF 3
c-Pen
H
CF 3
0
4-068.
1
3-CF 3
c-Pen
H
CF 2 H
0
4-069.
1
3-CF 3
c-Pen
H
CF 3
1
4-070.
1
3-CF 3
c-Pen
H
CF 2 H
1
4-071.
1
3-CF 3
c-Pen
H
CF 3
2
4-072.
1
3-CF 3
c-Pen
H
CF 2 H
2
4-073.
1
3-CF 3
c-Hex
H
CF 3
0
4-074.
1
3-CF 3
c-Hex
H
CF 2 H
0
4-075.
1
3-CF 3
c-Hex
H
CF 3
1
4-076.
1
3-CF 3
c-Hex
H
CF 2 H
1
4-077.
1
3-CF 3
c-Hex
H
CF 3
2
4-078.
1
3-CF 3
c-Hex
H
CF 2 H
2
4-079.
1
3-CF 3
CN
H
CF 3
0
4-080.
1
3-CF 3
CN
H
CF 2 H
0
4-081.
1
3-CF 3
CN
H
CF 3
1
4-082.
1
3-CF 3
CN
H
CF 2 H
1
4-083.
1
3-CF 3
CN
H
CF 3
2
4-084.
1
3-CF 3
CN
H
CF 2 H
2
4-085.
1
3-CF 3
COOMe
H
CF 3
0
4-086.
1
3-CF 3
COOMe
H
CF 2 H
0
4-087.
1
3-CF 3
COOMe
H
CF 3
1
4-088.
1
3-CF 3
COOMe
H
CF 2 H
1
4-089.
1
3-CF 3
COOMe
H
CF 3
2
4-090.
1
3-CF 3
COOMe
H
CF 2 H
2
4-091.
1
3-CF 3
COOEt
H
CF 3
0
4-092.
1
3-CF 3
COOEt
H
CF 2 H
0
4-093.
1
3-CF 3
COOEt
H
CF 3
1
4-094.
1
3-CF 3
COOEt
H
CF 2 H
1
4-095.
1
3-CF 3
COOEt
H
CF 3
2
4-096.
1
3-CF 3
COOEt
H
CF 2 H
2
4-097.
1
3-CF 3 -5-Me
H
H
CF 3
0
4-098.
1
3-CF 3 -5-Me
H
H
CF 2 H
0
4-099.
1
3-CF 3 -5-Me
H
H
CF 3
1
4-0100.
1
3-CF 3 -5-Me
H
H
CF 2 H
1
4-0101.
1
3-CF 3 -5-Me
H
H
CF 3
2
4-0102.
1
3-CF 3 -5-Me
H
H
CF 2 H
2
4-0103.
1
3-CF 3 -5-Me
Me
H
CF 3
0
4-0104.
1
3-CF 3 -5-Me
Me
H
CF 2 H
0
4-0105.
1
3-CF 3 -5-Me
Me
H
CF 3
1
4-0106.
1
3-CF 3 -5-Me
Me
H
CF 2 H
1
4-0107.
1
3-CF 3 -5-Me
Me
H
CF 3
2
4-0108.
1
3-CF 3 -5-Me
Me
H
CF 2 H
2
4-0109.
1
3-CF 3 -5-Me
CN
H
CF 3
0
4-0110.
1
3-CF 3 -5-Me
CN
H
CF 2 H
0
4-0111.
1
3-CF 3 -5-Me
CN
H
CF 3
1
4-0112.
1
3-CF 3 -5-Me
CN
H
CF 2 H
1
4-0113.
1
3-CF 3 -5-Me
CN
H
CF 3
2
4-0114.
1
3-CF 3 -5-Me
CN
H
CF 2 H
2
4-0115.
1
3-CF 3 -5-Me
COOMe
H
CF 3
0
4-0116.
1
3-CF 3 -5-Me
COOMe
H
CF 2 H
0
4-0117.
1
3-CF 3 -5-Me
COOMe
H
CF 3
1
4-0118.
1
3-CF 3 -5-Me
COOMe
H
CF 2 H
1
4-0119.
1
3-CF 3 -5-Me
COOMe
H
CF 3
2
4-0120.
1
3-CF 3 -5-Me
COOMe
H
CF 2 H
2
4-0121.
1
3-CF 3 -5-Me
COOEt
H
CF 3
0
4-0122.
1
3-CF 3 -5-Me
COOEt
H
CF 2 H
0
4-0123.
1
3-CF 3 -5-Me
COOEt
H
CF 3
1
4-0124.
1
3-CF 3 -5-Me
COOEt
H
CF 2 H
1
4-0125.
1
3-CF 3 -5-Me
COOEt
H
CF 3
2
4-0126.
1
3-CF 3 -5-Me
COOEt
H
CF 2 H
2
4-0127.
1
3-CF 3 -4-CN
H
H
CF 3
0
4-0128.
1
3-CF 3 -4-CN
H
H
CF 2 H
0
4-0129.
1
3-CF 3 -4-CN
H
H
CF 3
1
4-0130.
1
3-CF 3 -4-CN
H
H
CF 2 H
1
4-0131.
1
3-CF 3 -4-CN
H
H
CF 3
2
4-0132.
1
3-CF 3 -4-CN
H
H
CF 2 H
2
4-0133.
1
3-CF 3 -4-CN
H
H
CF 3
2
4-0134.
1
3-CF 3 -4-CN
H
H
CF 2 H
2
4-0135.
1
3-CF 3 -4-CN
Me
H
CF 3
0
4-0136.
1
3-CF 3 -4-CN
Me
H
CF 2 H
0
4-0137.
1
3-CF 3 -4-CN
Me
H
CF 3
1
4-0138.
1
3-CF 3 -4-CN
Me
H
CF 2 H
1
4-0139.
1
3-CF 3 -4-CN
Me
H
CF 3
2
4-0140.
1
3-CF 3 -4-CN
Me
H
CF 2 H
2
4-0141.
1
4-CF 3
H
H
CF 3
0
4-0142.
1
4-CF 3
H
H
CF 2 H
0
4-0143.
1
4-CF 3
H
H
CF 3
1
4-0144.
1
4-CF 3
H
H
CF 2 H
1
4-0145.
1
4-CF 3
H
H
CF 3
2
4-0146.
1
4-CF 3
H
H
CF 2 H
2
4-0147.
1
4-CF 3
Me
H
CF 3
0
4-0148.
1
4-CF 3
Me
H
CF 2 H
0
4-0149.
1
4-CF 3
Me
H
CF 3
1
4-0150.
1
4-CF 3
Me
H
CF 2 H
1
4-0151.
1
4-CF 3
Me
H
CF 3
2
4-0152.
1
4-CF 3
Me
H
CF 2 H
2
4-0153.
1
4-CF 3
Et
H
CF 3
0
4-0154.
1
4-CF 3
Et
H
CF 2 H
0
4-0155.
1
4-CF 3
Et
H
CF 3
1
4-0156.
1
4-CF 3
Et
H
CF 2 H
1
4-0157.
1
4-CF 3
Et
H
CF 3
2
4-0158.
1
4-CF 3
Et
H
CF 2 H
2
4-0159.
1
4-CF 3
i-Pr
H
CF 3
0
4-0160.
1
4-CF 3
i-Pr
H
CF 2 H
0
4-0161.
1
4-CF 3
i-Pr
H
CF 3
1
4-0162.
1
4-CF 3
i-Pr
H
CF 2 H
1
4-0163.
1
4-CF 3
i-Pr
H
CF 3
2
4-0164.
1
4-CF 3
i-Pr
H
CF 2 H
2
4-0165.
1
4-CF 3
c-Pr
H
CF 3
0
4-0166.
1
4-CF 3
c-Pr
H
CF 2 H
0
4-0167.
1
4-CF 3
c-Pr
H
CF 3
1
4-0168.
1
4-CF 3
c-Pr
H
CF 2 H
1
4-0169.
1
4-CF 3
c-Pr
H
CF 3
2
4-0170.
1
4-CF 3
c-Pr
H
CF 2 H
2
4-0171.
1
4-CF 3
Pr
H
CF 3
0
4-0172.
1
4-CF 3
Pr
H
CF 2 H
0
4-0173.
1
4-CF 3
Pr
H
CF 3
1
4-0174.
1
4-CF 3
Pr
H
CF 2 H
1
4-0175.
1
4-CF 3
Pr
H
CF 3
2
4-0176.
1
4-CF 3
Pr
H
CF 2 H
2
4-0177.
1
4-CF 3
s-Bu
H
CF 3
0
4-0178.
1
4-CF 3
s-Bu
H
CF 2 H
0
4-0179.
1
4-CF 3
s-Bu
H
CF 3
1
4-0180.
1
4-CF 3
s-Bu
H
CF 2 H
1
4-0181.
1
4-CF 3
s-Bu
H
CF 3
2
4-0182.
1
4-CF 3
s-Bu
H
CF 2 H
2
4-0183.
1
4-CF 3
i-Bu
H
CF 3
0
4-0184.
1
4-CF 3
i-Bu
H
CF 2 H
0
4-0185.
1
4-CF 3
i-Bu
H
CF 3
1
4-0186.
1
4-CF 3
i-Bu
H
CF 2 H
1
4-0187.
1
4-CF 3
i-Bu
H
CF 3
2
4-0188.
1
4-CF 3
i-Bu
H
CF 2 H
2
4-0189.
1
4-CF 3
Bu
H
CF 3
0
4-0190.
1
4-CF 3
Bu
H
CF 2 H
0
4-0191.
1
4-CF 3
Bu
H
CF 3
1
4-0192.
1
4-CF 3
Bu
H
CF 2 H
1
4-0193.
1
4-CF 3
Bu
H
CF 3
2
4-0194.
1
4-CF 3
Bu
H
CF 2 H
2
4-0195.
1
4-CF 3
2-Pen
H
CF 3
0
4-0196.
1
4-CF 3
2-Pen
H
CF 2 H
0
4-0197.
1
4-CF 3
2-Pen
H
CF 3
1
4-0198.
1
4-CF 3
2-Pen
H
CF 2 H
1
4-0199.
1
4-CF 3
2-Pen
H
CF 3
2
4-0200.
1
4-CF 3
2-Pen
H
CF 2 H
2
4-0201.
1
4-CF 3
3-Pen
H
CF 3
0
4-0202.
1
4-CF 3
3-Pen
H
CF 2 H
0
4-0203.
1
4-CF 3
3-Pen
H
CF 3
1
4-0204.
1
4-CF 3
3-Pen
H
CF 2 H
1
4-0205.
1
4-CF 3
3-Pen
H
CF 3
2
4-0206.
1
4-CF 3
3-Pen
H
CF 2 H
2
4-0207.
1
4-CF 3
c-Pen
H
CF 3
0
4-0208.
1
4-CF 3
c-Pen
H
CF 2 H
0
4-0209.
1
4-CF 3
c-Pen
H
CF 3
1
4-0210.
1
4-CF 3
c-Pen
H
CF 2 H
1
4-0211.
1
4-CF 3
c-Pen
H
CF 3
2
4-0212.
1
4-CF 3
c-Pen
H
CF 2 H
2
4-0213.
1
4-CF 3
c-Hex
H
CF 3
0
4-0214.
1
4-CF 3
c-Hex
H
CF 2 H
0
4-0215.
1
4-CF 3
c-Hex
H
CF 3
1
4-0216.
1
4-CF 3
c-Hex
H
CF 2 H
1
4-0217.
1
4-CF 3
c-Hex
H
CF 3
2
4-0218.
1
4-CF 3
c-Hex
H
CF 2 H
2
4-0219.
1
4-CF 3
CN
H
CF 3
0
4-0220.
1
4-CF 3
CN
H
CF 2 H
0
4-0221.
1
4-CF 3
CN
H
CF 3
1
4-0222.
1
4-CF 3
CN
H
CF 2 H
1
4-0223.
1
4-CF 3
CN
H
CF 3
2
4-0224.
1
4-CF 3
CN
H
CF 2 H
2
4-0225.
1
4-CF 3
COOMe
H
CF 3
0
4-0226.
1
4-CF 3
COOMe
H
CF 2 H
0
4-0227.
1
4-CF 3
COOMe
H
CF 3
1
4-0228.
1
4-CF 3
COOMe
H
CF 2 H
1
4-0229.
1
4-CF 3
COOMe
H
CF 3
2
4-0230.
1
4-CF 3
COOMe
H
CF 2 H
2
4-0231.
1
4-CF 3
COOEt
H
CF 3
0
4-0232.
1
4-CF 3
COOEt
H
CF 2 H
0
4-0233.
1
4-CF 3
COOEt
H
CF 3
1
4-0234.
1
4-CF 3
COOEt
H
CF 2 H
1
4-0235.
1
4-CF 3
COOEt
H
CF 3
2
4-0236.
1
4-CF 3
COOEt
H
CF 2 H
2
4-0237.
3
1-Me-5-OCHF 2
H
H
CF 3
0
4-0238.
3
1-Me-5-OCHF 2
H
H
CF 2 H
0
4-0239.
3
1-Me-5-OCHF 2
H
H
CF 3
1
4-0240.
3
1-Me-5-OCHF 2
H
H
CF 2 H
1
4-0241.
3
1-Me-5-OCHF 2
H
H
CF 3
2
4-0242.
3
1-Me-5-OCHF 2
H
H
CF 2 H
2
4-0243.
4
1-t-Bu
H
H
CF 3
0
4-0244.
4
1-t-Bu
H
H
CF 2 H
0
4-0245.
4
1-t-Bu
H
H
CF 3
1
4-0246.
4
1-t-Bu
H
H
CF 2 H
1
4-0247.
4
1-t-Bu
H
H
CF 3
2
4-0248.
4
1-t-Bu
H
H
CF 2 H
2
4-0249.
4
1-CHF 2
H
H
CF 3
0
4-0250.
4
1-CHF 2
H
H
CF 2 H
0
4-0251.
4
1-CHF 2
H
H
CF 3
1
4-0252.
4
1-CHF 2
H
H
CF 2 H
1
4-0253.
4
1-CHF 2
H
H
CF 3
2
4-0254.
4
1-CHF 2
H
H
CF 2 H
2
4-0255.
4
1-Me-3-CF 3 -5-OCHF 2
H
H
CF 3
0
4-0256.
4
1-Me-3-CF 3 -5-OCHF 2
H
H
CF 2 H
0
4-0257.
4
1-Me-3-CF 3 -5-OCHF 2
H
H
CF 3
1
4-0258.
4
1-Me-3-CF 3 -5-OCHF 2
H
H
CF 2 H
1
4-0259.
4
1-Me-3-CF 3 -5-OCHF 2
H
H
CF 3
2
4-0260.
4
1-Me-3-CF 3 -5-OCHF 2
H
H
CF 2 H
2
4-0261.
5
1-Me-3-OCHF 2
H
H
CF 3
0
4-0262.
5
1-Me-3-OCHF 2
H
H
CF 2 H
0
4-0263.
5
1-Me-3-OCHF 2
H
H
CF 3
1
4-0264.
5
1-Me-3-OCHF 2
H
H
CF 2 H
1
4-0265.
5
1-Me-3-OCHF 2
H
H
CF 3
2
4-0266.
5
1-Me-3-OCHF 2
H
H
CF 2 H
2
4-0267.
1
3-CF 3
CO 2 Me
Me
CF 3
0
4-0268.
1
3-CF 3
CO 2 Me
Me
CF 2 H
0
4-0269.
1
3-CF 3
CO 2 Me
Me
CF 3
1
4-0270.
1
3-CF 3
CO 2 Me
Me
CF 2 H
1
4-0271.
1
3-CF 3
CO 2 Me
Me
CF 3
2
4-0272.
1
3-CF 3
CO 2 Me
Me
CF 2 H
2
4-0273.
1
3-CF 3
CO 2 Et
Me
CF 3
0
4-0274.
1
3-CF 3
CO 2 Et
Me
CF 2 H
0
4-0275.
1
3-CF 3
CO 2 Et
Me
CF 3
1
4-0276.
1
3-CF 3
CO 2 Et
Me
CF 2 H
1
4-0277.
1
3-CF 3
CO 2 Et
Me
CF 3
2
4-0278.
1
3-CF 3
CO 2 Et
Me
CF 2 H
2
4-0279.
1
3-CF 3
CO 2 -i-Pr
Me
CF 3
0
4-0280.
1
3-CF 3
CO 2 -i-Pr
Me
CF 2 H
0
4-0281.
1
3-CF 3
CO 2 -i-Pr
Me
CF 3
1
4-0282.
1
3-CF 3
CO 2 -i-Pr
Me
CF 2 H
1
4-0283.
1
3-CF 3
CO 2 -i-Pr
Me
CF 3
2
4-0284.
1
3-CF 3
CO 2 -i-Pr
Me
CF 2 H
2
4-0285.
1
3-CF 3
CO 2 -i-Pr
Me
CF 3
2
4-0286.
1
3-CF 3
CO 2 -t-Bu
H
CF 2 H
0
4-0287.
1
3-CF 3
CO 2 -t-Bu
H
CF 3
0
4-0288.
1
3-CF 3
CO 2 -t-Bu
H
CF 2 H
1
4-0289.
1
3-CF 3
CO 2 -t-Bu
H
CF 3
1
4-0290.
1
3-CF 3
CO 2 -t-Bu
H
CF 2 H
2
4-0291.
1
3-CF 3
CO 2 -t-Bu
H
CF 3
2
4-0292.
1
3-CF 3
CO 2 -t-Bu
Me
CF 2 H
0
4-0293.
1
3-CF 3
CO 2 -t-Bu
Me
CF 3
0
4-0294.
1
3-CF 3
CO 2 -t-Bu
Me
CF 2 H
1
4-0295.
1
3-CF 3
CO 2 -t-Bu
Me
CF 3
1
4-0296.
1
3-CF 3
CO 2 -t-Bu
Me
CF 2 H
2
4-0297.
1
3-CF 3
CO 2 -t-Bu
Me
CF 3
2
4-0298.
1
3-CF 3
CO 2 -c-Pen
Me
CF 2 H
0
4-0299.
1
3-CF 3
CO 2 -c-Pen
Me
CF 3
0
4-0300.
1
3-CF 3
CO 2 -c-Pen
Me
CF 2 H
1
4-0301.
1
3-CF 3
CO 2 -c-Pen
Me
CF 3
1
4-0302.
1
3-CF 3
CO 2 -c-Pen
Me
CF 2 H
2
4-0303.
1
3-CF 3
CO 2 -c-Pen
Me
CF 3
2
4-0304.
1
3-CF 3
CO 2 CH 2 CF 3
Me
CF 2 H
0
4-0305.
1
3-CF 3
CO 2 CH 2 CF 3
Me
CF 3
0
4-0306.
1
3-CF 3
CO 2 CH 2 CF 3
Me
CF 2 H
1
4-0307.
1
3-CF 3
CO 2 CH 2 CF 3
Me
CF 3
1
4-0308.
1
3-CF 3
CO 2 CH 2 CF 3
Me
CF 2 H
2
4-0309.
1
3-CF 3
CO 2 CH 2 CF 3
Me
CF 3
2
4-0310.
1
3-CF 3
CO 2 (CH 2 ) 2 OMe
Me
CF 2 H
0
4-0311.
1
3-CF 3
CO 2 (CH 2 ) 2 OMe
Me
CF 3
0
4-0312.
1
3-CF 3
CO 2 (CH 2 ) 2 OMe
Me
CF 2 H
1
4-0313.
1
3-CF 3
CO 2 (CH 2 ) 2 OMe
Me
CF 3
1
4-0314.
1
3-CF 3
CO 2 (CH 2 ) 2 OMe
Me
CF 2 H
2
4-0315.
1
3-CF 3
CO 2 (CH 2 ) 2 OMe
Me
CF 3
2
4-0316.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 2 H
0
4-0317.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 3
0
4-0318.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 2 H
1
4-0319.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 3
1
4-0320.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 2 H
2
4-0321.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 3
2
4-0322.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 2 H
0
4-0323.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 3
0
4-0324.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 2 H
1
4-0325.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 3
1
4-0326.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 2 H
2
4-0327.
1
3-CF 3
CO 2 CH(Me)CH 2 OMe
Me
CF 3
2
4-0328.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 2 H
0
4-0329.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 3
0
4-0330.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 2 H
1
4-0331.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 3
1
4-0332.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 2 H
2
4-0333.
1
3-CF 3
CO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
Me
CF 3
2
4-0334.
1
3-CF 3
CO 2 (CH 2 ) 2 SMe
Me
CF 2 H
0
4-0335.
1
3-CF 3
CO 2 (CH 2 ) 2 SMe
Me
CF 3
0
4-0336.
1
3-CF 3
CO 2 (CH 2 ) 2 SO 2 Me
Me
CF 2 H
2
4-0337.
1
3-CF 3
CO 2 (CH 2 ) 2 SO 2 Me
Me
CF 3
2
4-0338.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 2 H
0
4-0339.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 3
0
4-0340.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 2 H
1
4-0341.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 3
1
4-0342.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 2 H
2
4-0343.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 3
2
4-0344.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 2 H
0
4-0345.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 3
0
4-0346.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 2 H
1
4-0347.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 3
1
4-0348.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 2 H
2
4-0349.
1
3-CF 3
CO 2 CH(CH 3 )CONH 2
Me
CF 3
2
4-0350.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 2 H
0
4-0351.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 3
0
4-0352.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 2 H
1
4-0353.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 3
1
4-0354.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 3
2
4-0355.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 2 H
2
4-0356.
1
3-CF 3
CO 2 CH 2 CH 2 Cl
Me
CF 3
0
4-0357.
1
3-CF 3
CO 2 CH 2 CH 2 Cl
Me
CF 2 H
0
4-0358.
1
3-CF 3
CO 2 CH 2 CH 2 Cl
Me
CF 3
1
4-0359.
1
3-CF 3
CO 2 CH 2 CH 2 Cl
Me
CF 2 H
1
4-0360.
1
3-CF 3
CO 2 CH 2 CH 2 Cl
Me
CF 3
2
4-0361.
1
3-CF 3
CO 2 CH 2 CH 2 Cl
Me
CF 2 H
2
4-0362.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
H
CF 3
0
4-0363.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
H
CF 2 H
0
4-0364.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
H
CF 3
1
4-0365.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
H
CF 2 H
1
4-0366.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
H
CF 3
2
4-0367.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
H
CF 2 H
2
4-0368.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
Me
CF 3
0
4-0369.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
Me
CF 2 H
0
4-0370.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
Me
CF 3
1
4-0371.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
Me
CF 2 H
1
4-0372.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
Me
CF 3
2
4-0373.
1
3-CF 3
CO 2 C(Me) 2 CO 3 Et
Me
CF 2 H
2
4-0374.
1
3-CF 3
COO-E 2
Me
CF 3
0
4-0375.
1
3-CF 3
COO-E 2
Me
CF 2 H
0
4-0376.
1
3-CF 3
COO-E 2
Me
CF 3
1
4-0377.
1
3-CF 3
COO-E 2
Me
CF 2 H
1
4-0378.
1
3-CF 3
COO-E 2
Me
CF 3
2
4-0379.
1
3-CF 3
COO-E 2
Me
CF 2 H
2
4-0380.
1
3-CF 3
COO-E 3
Me
CF 3
0
4-0381.
1
3-CF 3
COO-E 3
Me
CF 2 H
0
4-0382.
1
3-CF 3
COO-E 3
Me
CF 3
1
4-0383.
1
3-CF 3
COO-E 3
Me
CF 2 H
1
4-0384.
1
3-CF 3
COO-E 3
Me
CF 3
2
4-0385.
1
3-CF 3
COO-E 3
Me
CF 2 H
2
4-0386.
1
3-CF 3
COO-E 4
Me
CF 3
0
4-0387.
1
3-CF 3
COO-E 4
Me
CF 2 H
0
4-0388.
1
3-CF 3
COO-E 4
Me
CF 3
1
4-0389.
1
3-CF 3
COO-E 4
Me
CF 2 H
1
4-0390.
1
3-CF 3
COO-E 4
Me
CF 3
2
4-0391.
1
3-CF 3
COO-E 4
Me
CF 2 H
2
4-0392.
1
3-CF 3
COOCH 2 -E 1
Me
CF 3
0
4-0393.
1
3-CF 3
COOCH 2 -E 1
Me
CF 2 H
0
4-0394.
1
3-CF 3
COOCH 2 -E 1
Me
CF 3
1
4-0395.
1
3-CF 3
COOCH 2 -E 1
Me
CF 2 H
1
4-0396.
1
3-CF 3
COOCH 2 -E 1
Me
CF 3
2
4-0397.
1
3-CF 3
COOCH 2 -E 1
Me
CF 2 H
2
4-0398.
1
3-CF 3
COOCH 2 -E 2
Me
CF 3
0
4-0399.
1
3-CF 3
COOCH 2 -E 2
Me
CF 2 H
0
4-0400.
1
3-CF 3
COOCH 2 -E 2
Me
CF 3
1
4-0401.
1
3-CF 3
COOCH 2 -E 2
Me
CF 2 H
1
4-0402.
1
3-CF 3
COOCH 2 -E 2
Me
CF 3
2
4-0403.
1
3-CF 3
COOCH 2 -E 2
Me
CF 2 H
2
4-0404.
1
3-CF 3
CONH-i-Pr
Me
CF 3
0
4-0405.
1
3-CF 3
CONH-i-Pr
Me
CF 2 H
0
4-0406.
1
3-CF 3
CONH-i-Pr
Me
CF 3
1
4-0407.
1
3-CF 3
CONH-i-Pr
Me
CF 2 H
1
4-0408.
1
3-CF 3
CONH-i-Pr
Me
CF 3
2
4-0409.
1
3-CF 3
CONH-i-Pr
Me
CF 2 H
2
4-0410.
1
3-CF 3
Ac
H
CF 3
0
4-0411.
1
3-CF 3
Ac
H
CF 2 H
0
4-0412.
1
3-CF 3
Ac
H
CF 3
1
4-0413.
1
3-CF 3
Ac
H
CF 2 H
1
4-0414.
1
3-CF 3
Ac
H
CF 3
2
4-0415.
1
3-CF 3
Ac
H
CF 2 H
2
4-0416.
1
3-CF 3
Ac
Me
CF 3
0
4-0417.
1
3-CF 3
Ac
Me
CF 2 H
0
4-0418.
1
3-CF 3
Ac
Me
CF 3
1
4-0419.
1
3-CF 3
Ac
Me
CF 2 H
1
4-0420.
1
3-CF 3
Ac
Me
CF 3
2
4-0421.
1
3-CF 3
Ac
Me
CF 2 H
2
4-0422.
1
3-CF 3 -4-Cl
COO-t-Bu
H
CF 3
0
4-0423.
1
3-CF 3 -4-Cl
COO-t-Bu
H
CF 2 H
0
4-0424.
1
3-CF 3 -4-Cl
COO-t-Bu
H
CF 3
1
4-0425.
1
3-CF 3 -4-Cl
COO-t-Bu
H
CF 2 H
1
4-0426.
1
3-CF 3 -4-Cl
COO-t-Bu
H
CF 3
2
4-0427.
1
3-CF 3 -4-Cl
COO-t-Bu
H
CF 2 H
2
4-0428.
1
3-CF 3 -4-Cl
COO-t-Bu
Me
CF 3
0
4-0429.
1
3-CF 3 -4-Cl
COO-t-Bu
Me
CF 2 H
0
4-0430.
1
3-CF 3 -4-Cl
COO-t-Bu
Me
CF 3
1
4-0431.
1
3-CF 3 -4-Cl
COO-t-Bu
Me
CF 2 H
1
4-0432.
1
3-CF 3 -4-Cl
COO-t-Bu
Me
CF 3
2
4-0433.
1
3-CF 3 -4-Cl
COO-t-Bu
Me
CF 2 H
2
4-0434.
1
3-CF 3 -4-NO 2
COO-t-Bu
H
CF 3
0
4-0435.
1
3-CF 3 -4-NO 2
COO-t-Bu
H
CF 2 H
0
4-0436.
1
3-CF 3 -4-NO 2
COO-t-Bu
H
CF 3
1
4-0437.
1
3-CF 3 -4-NO 2
COO-t-Bu
H
CF 2 H
1
4-0438.
1
3-CF 3 -4-NO 2
COO-t-Bu
H
CF 3
2
4-0439.
1
3-CF 3 -4-NO 2
COO-t-Bu
H
CF 2 H
2
4-0440.
1
3-CF 3 -4-NO 2
COO-t-Bu
Me
CF 3
0
4-0441.
1
3-CF 3 -4-NO 2
COO-t-Bu
Me
CF 2 H
0
4-0442.
1
3-CF 3 -4-NO 2
COO-t-Bu
Me
CF 3
1
4-0443.
1
3-CF 3 -4-NO 2
COO-t-Bu
Me
CF 2 H
1
4-0444.
1
3-CF 3 -4-NO 2
COO-t-Bu
Me
CF 3
2
4-0445.
1
3-CF 3 -4-NO 2
COO-t-Bu
Me
CF 2 H
2
4-0446.
1
3-CF 3 -5-Me
COO-t-Bu
H
CF 3
0
4-0447.
1
3-CF 3 -5-Me
COO-t-Bu
H
CF 2 H
0
4-0448.
1
3-CF 3 -5-Me
COO-t-Bu
H
CF 3
1
4-0449.
1
3-CF 3 -5-Me
COO-t-Bu
H
CF 2 H
1
4-0450.
1
3-CF 3 -5-Me
COO-t-Bu
H
CF 3
2
4-0451.
1
3-CF 3 -5-Me
COO-t-Bu
H
CF 2 H
2
4-0452.
1
3-CF 3 -5-Me
COO-t-Bu
Me
CF 3
0
4-0453.
1
3-CF 3 -5-Me
COO-t-Bu
Me
CF 2 H
0
4-0454.
1
3-CF 3 -5-Me
COO-t-Bu
Me
CF 3
1
4-0455.
1
3-CF 3 -5-Me
COO-t-Bu
Me
CF 2 H
1
4-0456.
1
3-CF 3 -5-Me
COO-t-Bu
Me
CF 3
2
4-0457.
1
3-CF 3 -5-Me
COO-t-Bu
Me
CF 2 H
2
4-0458.
1
5-CF 3
COOMe
H
CF 3
0
4-0459.
1
5-CF 3
COOMe
H
CF 2 H
0
4-0460.
1
5-CF 3
COOMe
H
CF 3
1
4-0461.
1
5-CF 3
COOMe
H
CF 2 H
1
4-0462.
1
5-CF 3
COOMe
H
CF 3
2
4-0463.
1
5-CF 3
COOMe
H
CF 2 H
2
4-0464.
1
3-t-Bu
COO-t-Bu
Me
CF 3
0
4-0465.
1
3-t-Bu
COO-t-Bu
Me
CF 2 H
0
4-0466.
1
3-t-Bu
COO-t-Bu
Me
CF 3
1
4-0467.
1
3-t-Bu
COO-t-Bu
Me
CF 2 H
1
4-0468.
1
3-t-Bu
COO-t-Bu
Me
CF 3
2
4-0469.
1
3-t-Bu
COO-t-Bu
Me
CF 2 H
2
4-0470.
4
1-t-Bu-3-CF 3 -5-Cl
H
H
CF 3
0
4-0471.
4
1-t-Bu-3-CF 3 -5-Cl
H
H
CF 2 H
0
4-0472.
4
1-t-Bu-3-CF 3 -5-Cl
H
H
CF 3
1
4-0473.
4
1-t-Bu-3-CF 3 -5-Cl
H
H
CF 2 H
1
4-0474.
4
1-t-Bu-3-CF 3 -5-Cl
H
H
CF 3
2
4-0475.
4
1-t-Bu-3-CF 3 -5-Cl
H
H
CF 2 H
2
4-0476.
4
1-t-Bu-3-CF 3 -5-Cl
Me
H
CF 3
2
4-0477.
4
1-t-Bu-3-CF 3 -5-Cl
Me
H
CF 2 H
2
4-0478.
4
1-t-Bu-3-CF 3
Me
H
CF 3
2
4-0479.
4
1-t-Bu-3-CF 3
Me
H
CF 2 H
2
4-0480.
1
CF 3
COO-i-Pr
H
CF 3
0
4-0481.
1
CF 3
COO-i-Pr
H
CF 2 H
0
4-0482.
1
CF 3
COO-i-Pr
H
CF 3
1
4-0483.
1
CF 3
COO-i-Pr
H
CF 2 H
1
4-0484.
1
CF 3
COO-i-Pr
H
CF 3
2
4-0485.
1
CF 3
COO-i-Pr
H
CF 2 H
2
4-0486.
1
CF 3
COOH
Me
CF 3
0
4-0487.
1
CF 3
COOH
Me
CF 2 H
0
wherein m is 0 or 1;
Position in Table 4 is the position on the pyrazoyl group which is substituted by the moiety
V, R 1 , R 2 , R 3U and n are defined in Table 4; and
E 1 , E 2 , E 3 and E 4 are the following structures:
17. A compound of formula 5-xxxx, selected from Table 5:
TABLE 5
5-xxxx
No.
position
V
R 1
R 2
R 3U
n
5-01.
1
3-CF 3
H
H
CF 3
0
5-02.
1
3-CF 3
H
H
CF 3
1
5-03.
1
3-CF 3
H
H
CF 3
2
5-04.
1
3-CF 3
Me
H
CF 3
0
5-05.
1
3-CF 3
Me
H
CF 3
1
5-06.
1
3-CF 3
Me
H
CF 3
2
5-07.
1
3-CF 3
Me
Me
CF 3
2
5-08.
1
3-CF 3
Et
H
CF 3
0
5-09.
1
3-CF 3
Et
H
CF 3
1
5-010.
1
3-CF 3
Et
H
CF 3
2
5-011.
1
3-CF 3
i-Pr
H
CF 3
0
5-012.
1
3-CF 3
i-Pr
H
CF 3
1
5-013.
1
3-CF 3
i-Pr
H
CF 3
2
5-014.
1
3-CF 3
c-Pr
H
CF 3
0
5-015.
1
3-CF 3
c-Pr
H
CF 3
1
5-016.
1
3-CF 3
c-Pr
H
CF 3
2
5-017.
1
3-CF 3
Pr
H
CF 3
0
5-018.
1
3-CF 3
Pr
H
CF 3
1
5-019.
1
3-CF 3
Pr
H
CF 3
2
5-020.
1
3-CF 3
s-Bu
H
CF 3
0
5-021.
1
3-CF 3
s-Bu
H
CF 3
1
5-022.
1
3-CF 3
s-Bu
H
CF 3
2
5-023.
1
3-CF 3
i-Bu
H
CF 3
0
5-024.
1
3-CF 3
i-Bu
H
CF 3
1
5-025.
1
3-CF 3
i-Bu
H
CF 3
2
5-026.
1
3-CF 3
Bu
H
CF 3
0
5-027.
1
3-CF 3
Bu
H
CF 3
1
5-028.
1
3-CF 3
Bu
H
CF 3
2
5-029.
1
3-CF 3
2-Pen
H
CF 3
0
5-030.
1
3-CF 3
2-Pen
H
CF 3
1
5-031.
1
3-CF 3
2-Pen
H
CF 3
2
5-032.
1
3-CF 3
3-Pen
H
CF 3
0
5-033.
1
3-CF 3
3-Pen
H
CF 3
1
5-034.
1
3-CF 3
3-Pen
H
CF 3
2
5-035.
1
3-CF 3
c-Pen
H
CF 3
0
5-036.
1
3-CF 3
c-Pen
H
CF 3
1
5-037.
1
3-CF 3
c-Pen
H
CF 3
2
5-038.
1
3-CF 3
c-Hex
H
CF 3
0
5-039.
1
3-CF 3
c-Hex
H
CF 3
1
5-040.
1
3-CF 3
c-Hex
H
CF 3
2
5-041.
1
3-CF 3
CN
H
CF 3
0
5-042.
1
3-CF 3
CN
H
CF 3
1
5-043.
1
3-CF 3
CN
H
CF 3
2
5-044.
1
3-CF 3
COOMe
H
CF 3
0
5-045.
1
3-CF 3
COOMe
H
CF 3
1
5-046.
1
3-CF 3
COOMe
H
CF 3
2
5-047.
1
3-CF 3
COOEt
H
CF 3
0
5-048.
1
3-CF 3
COOEt
H
CF 3
1
5-049.
1
3-CF 3
COOEt
H
CF 3
2
5-050.
1
3-SCF 3
H
H
CF 3
0
5-051.
1
3-SCF 3
H
H
CF 3
1
5-052.
1
3-SCF 3
H
H
CF 3
2
5-053.
1
3-SCF 3
Me
H
CF 3
0
5-054.
1
3-SCF 3
Me
H
CF 3
1
5-055.
1
3-SCF 3
Me
H
CF 3
2
5-056.
1
3-CF 3 -5-Me
H
H
CF 3
0
5-057.
1
3-CF 3 -5-Me
H
H
CF 3
1
5-058.
1
3-CF 3 -5-Me
H
H
CF 3
2
5-059.
1
3-CF 3 -5-Me
Me
H
CF 3
0
5-060.
1
3-CF 3 -5-Me
Me
H
CF 3
1
5-061.
1
3-CF 3 -5-Me
Me
H
CF 3
2
5-062.
1
3-CF 3 -5-Me
CN
H
CF 3
0
5-063.
1
3-CF 3 -5-Me
CN
H
CF 3
1
5-064.
1
3-CF 3 -5-Me
CN
H
CF 3
2
5-065.
1
3-CF 3 -5-Me
COOMe
H
CF 3
0
5-066.
1
3-CF 3 -5-Me
COOMe
H
CF 3
1
5-067.
1
3-CF 3 -5-Me
COOMe
H
CF 3
2
5-068.
1
3-CF 3 -5-Me
COOEt
H
CF 3
0
5-069.
1
3-CF 3 -5-Me
COOEt
H
CF 3
1
5-070.
1
3-CF 3 -5-Me
COOEt
H
CF 3
2
5-071.
3
—
H
H
CF 3
0
5-072.
3
1-CH 2 CF 3
H
H
CF 3
0
5-073.
3
1-CH 2 CF 3
H
H
CF 3
1
5-074.
3
1-CH 2 CF 3
H
H
CF 3
2
5-075.
3
1-CBrF 2
H
H
CF 3
0
5-076.
3
1-CBrF 2
H
H
CF 3
1
5-077.
3
1-CBrF 2
H
H
CF 3
2
5-078.
3
1-CHF 2
H
H
CF 3
0
5-079.
3
1-CHF 2
H
H
CF 3
1
5-080.
3
1-CHF 2
H
H
CF 3
2
5-081.
3
1-CH 2 —c-Pr
H
H
CF 3
0
5-082.
3
1-CH 2 —c-Pr
H
H
CF 3
1
5-083.
3
1-CH 2 —c-Pr
H
H
CF 3
2
5-084.
3
1-CF 2 CHF 2
H
H
CF 3
0
5-085.
3
1-CF 2 CHF 2
H
H
CF 3
1
5-086.
3
1-CF 2 CHF 2
H
H
CF 3
2
5-087.
3
1-CF═F 2
H
H
CF 3
0
5-088.
3
1-CF═F 2
H
H
CF 3
1
5-089.
3
1-CF═F 2
H
H
CF 3
2
5-090.
5
1-CBrF 2
H
H
CF 3
0
5-091.
5
1-CBrF 2
H
H
CF 3
1
5-092.
5
1-CBrF 2
H
H
CF 3
2
5-093.
1
3-CF 3
CH 2 OH
H
CF 3
0
5-094.
1
3-CF 3
CH 2 OH
H
CF 3
1
5-095.
1
3-CF 3
CH 2 OH
H
CF 3
2
5-096.
1
3-CF 3
CH 2 OH
Me
CF 3
0
5-097.
1
3-CF 3
CH 2 OH
Me
CF 3
1
5-098.
1
3-CF 3
CH 2 OH
Me
CF 3
2
5-099.
1
3-CF 3
CH 2 OMe
Me
CF 3
0
5-0100.
1
3-CF 3
CH 2 OMe
Me
CF 3
1
5-0101.
1
3-CF 3
CH 2 OMe
Me
CF 3
2
5-0102.
1
3-CF 3
CH 2 OAc
Me
CF 3
0
5-0103.
1
3-CF 3
CH 2 OAc
Me
CF 3
1
5-0104.
1
3-CF 3
CH 2 OAc
Me
CF 3
2
5-0105.
1
3-CF 3
CH 2 OCO—t-Bu
Me
CF 3
0
5-0106.
1
3-CF 3
CH 2 OCO—t-Bu
Me
CF 3
1
5-0107.
1
3-CF 3
CH 2 OCO—t-Bu
Me
CF 3
2
5-0108.
1
3-CF 3
CH 2 OCONMe 2
Me
CF 3
0
5-0109.
1
3-CF 3
CH 2 OCONMe 2
Me
CF 3
1
5-0110.
1
3-CF 3
CH 2 OCONMe 2
Me
CF 3
2
5-0111.
1
3-CF 3
CH(Me)OH
Me
CF 3
0
5-0112.
1
3-CF 3
CH(Me)OH
Me
CF 3
2
5-0113.
1
3-CF 3
CH(Me)OMe
Me
CF 3
0
5-0114.
1
3-CF 3
CH(Me)OMe
Me
CF 3
2
5-0115.
1
3-CF 3
CH(OH)—t-Bu
Me
CF 3
0
5-0116.
1
3-CF 3
COOH
Me
CF 3
0
5-0117.
1
3-CF 3
COOMe
Me
CF 3
0
5-0118.
1
3-CF 3
COOMe
Me
CF 3
1
5-0119.
1
3-CF 3
COOMe
Me
CF 3
2
5-0120.
1
3-CF 3
COOEt
Me
CF 3
0
5-0121.
1
3-CF 3
COOEt
Me
CF 3
1
5-0122.
1
3-CF 3
COOEt
Me
CF 3
2
5-0123.
1
3-CF 3
COO—i-Pr
H
CF 3
0
5-0124.
1
3-CF 3
COO—i-Pr
H
CF 3
1
5-0125.
1
3-CF 3
COO—i-Pr
H
CF 3
2
5-0126.
1
3-CF 3
COO—i-Pr
Me
CF 3
0
5-0127.
1
3-CF 3
COO—i-Pr
Me
CF 3
1
5-0128.
1
3-CF 3
COO—i-Pr
Me
CF 3
2
5-0129.
1
3-CF 3
COO—t-Bu
H
CF 3
0
5-0130.
1
3-CF 3
COO—t-Bu
H
CF 3
1
5-0131.
1
3-CF 3
COO—t-Bu
H
CF 3
2
5-0132.
1
3-CF 3
COO—t-Bu
Me
CF 3
0
5-0133.
1
3-CF 3
COO—t-Bu
Me
CF 3
1
5-0134.
1
3-CF 3
COO—t-Bu
Me
CF 3
2
5-0135.
1
3-CF 3
COO—i-Bu
Me
CF 3
0
5-0136.
1
3-CF 3
COO—i-Bu
Me
CF 3
1
5-0137.
1
3-CF 3
COO—i-Bu
Me
CF 3
2
5-0138.
1
3-CF 3
COO—s-Bu
Me
CF 3
0
5-0139.
1
3-CF 3
COO—s-Bu
Me
CF 3
1
5-0140.
1
3-CF 3
COO—s-Bu
Me
CF 3
2
5-0141.
1
3-CF 3
COO—c-Pen
Me
CF 3
0
5-0142.
1
3-CF 3
COO—c-Pen
Me
CF 3
1
5-0143.
1
3-CF 3
COO—c-Pen
Me
CF 3
2
5-0144.
1
3-CF 3
COOCH 2 —t-Bu
Me
CF 3
0
5-0145.
1
3-CF 3
COOCH 2 —t-Bu
Me
CF 3
1
5-0146.
1
3-CF 3
COOCH 2 —t-Bu
Me
CF 3
2
5-0147.
1
3-CF 3
COOCH 2 —c-Pr
Me
CF 3
0
5-0148.
1
3-CF 3
COOCH 2 —c-Pr
Me
CF 3
1
5-0149.
1
3-CF 3
COOCH 2 —c-Pr
Me
CF 3
2
5-0150.
1
3-CF 3
COOCH 2 CF 3
Me
CF 3
0
5-0151.
1
3-CF 3
COOCH 2 CF 3
Me
CF 3
1
5-0152.
1
3-CF 3
COOCH 2 CF 3
Me
CF 3
2
5-0153.
1
3-CF 3
CO 2 CH 2 C═CH
Me
CF 3
0
5-0154.
1
3-CF 3
CO 2 CH 2 C═CH
Me
CF 3
1
5-0155.
1
3-CF 3
CO 2 CH 2 C═CH
Me
CF 3
2
5-0156.
1
3-CF 3
CO 2 CH 2 CH═CH 2
Me
CF 3
0
5-0157.
1
3-CF 3
CO 2 CH 2 CH═CH 2
Me
CF 3
1
5-0158.
1
3-CF 3
CO 2 CH 2 CH═CH 2
Me
CF 3
2
5-0159.
1
3-CF 3
CO 2 CH 2 CH 2 OMe
Me
CF 3
0
5-0160.
1
3-CF 3
CO 2 CH 2 CH 2 OMe
Me
CF 3
1
5-0161.
1
3-CF 3
CO 2 CH 2 CH 2 OMe
Me
CF 3
2
5-0162.
1
3-CF 3
CO 2 CH 2 CH 2 SMe
Me
CF 3
0
5-0163.
1
3-CF 3
CO 2 CH 2 CH 2 SO 2 Me
Me
CF 3
0
5-0164.
1
3-CF 3
CO 2 CH 2 CH 2 SO 2 Me
Me
CF 3
1
5-0165.
1
3-CF 3
CO 2 CH 2 CH 2 SO 2 Me
Me
CF 3
2
5-0166.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 3
0
5-0167.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 3
1
5-0168.
1
3-CF 3
CO 2 CH 2 CONH 2
Me
CF 3
2
5-0169.
1
3-CF 3
CO 2 CH(Me)C═CH
Me
CF 3
0
5-0170.
1
3-CF 3
CO 2 CH(Me)C═CH
Me
CF 3
1
5-0171.
1
3-CF 3
CO 2 CH(Me)C═CH
Me
CF 3
2
5-0172.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 3
0
5-0173.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 3
1
5-0174.
1
3-CF 3
CO 2 CH(Me)CN
Me
CF 3
2
5-0175.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 3
0
5-0176.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 3
1
5-0177.
1
3-CF 3
CO 2 CH(Me)CONH 2
Me
CF 3
2
5-0178.
1
3-CF 3
CO 2 C(Me) 2 COOEt
H
CF 3
0
5-0179.
1
3-CF 3
CO 2 C(Me) 2 COOEt
H
CF 3
1
5-0180.
1
3-CF 3
CO 2 C(Me) 2 COOEt
H
CF 3
2
5-0181.
1
3-CF 3
CO 2 C(Me) 2 COOEt
Me
CF 3
0
5-0182.
1
3-CF 3
CO 2 C(Me) 2 COOEt
Me
CF 3
1
5-0183.
1
3-CF 3
CO 2 C(Me) 2 COOEt
Me
CF 3
2
5-0184.
1
3-CF 3
COOCH 2 —E 1
Me
CF 3
0
5-0185.
1
3-CF 3
COOCH 2 —E 1
Me
CF 3
1
5-0186.
1
3-CF 3
COOCH 2 —E 1
Me
CF 3
2
5-0187.
1
3-CF 3
COO—E 2
Me
CF 3
0
5-0188.
1
3-CF 3
COO—E 2
Me
CF 3
1
5-0189.
1
3-CF 3
COO—E 2
Me
CF 3
2
5-0190.
1
3-CF 3
COO—E 3
Me
CF 3
0
5-0191.
1
3-CF 3
COO—E 3
Me
CF 3
1
5-0192.
1
3-CF 3
COO—E 3
Me
CF 3
2
5-0193.
1
3-CF 3
COO—E 4
Me
CF 3
0
5-0194.
1
3-CF 3
COO—E 4
Me
CF 3
1
5-0195.
1
3-CF 3
COO—E 4
Me
CF 3
2
5-0196.
1
3-CF 3
COOCH 2 Ph
Me
CF 3
0
5-0197.
1
3-CF 3
COOCH 2 Ph
Me
CF 3
1
5-0198.
1
3-CF 3
COOCH 2 Ph
Me
CF 3
2
5-0199.
1
3-CF 3
CO 2 CH(Me)—E 6
Me
CF 3
0
5-0200.
1
3-CF 3
CO 2 CH(Me)—E 6
Me
CF 3
1
5-0201.
1
3-CF 3
CO 2 CH(Me)—E 6
Me
CF 3
2
5-0202.
1
3-CF 3
COO—E 7
Me
CF 3
0
5-0203.
1
3-CF 2
COO—E 7
Me
CF 3
1
5-0204.
1
3-CF 3
COO—E 7
Me
CF 3
2
5-0205.
1
3-CF 3
COS—i-Pr
Me
CF 3
0
5-0206.
1
3-CF 3
COS—i-Pr
Me
CF 3
1
5-0207.
1
3-CF 3
COS—i-Pr
Me
CF 3
2
5-0208.
1
3-CF 3
COS—t-Bu
Me
CF 3
0
5-0209.
1
3-CF 3
COS—t-Bu
Me
CF 3
1
5-0210.
1
3-CF 3
COS—t-Bu
Me
CF 3
2
5-0211.
1
3-CF 3
COS—c-Hex
Me
CF 3
0
5-0212.
1
3-CF 3
COS—c-Hex
Me
CF 3
1
5-0213.
1
3-CF 3
COS—c-Hex
Me
CF 3
2
5-0214.
1
3-CF 3
CONHMe
Me
CF 3
2
5-0215.
1
3-CF 3
CONH—i-Pr
Me
CF 3
2
5-0216.
1
3-CF 3
CONHCONH 2
Me
CF 3
0
5-0217.
1
3-CF 3
CONHCONH 2
Me
CF 3
1
5-0218.
1
3-CF 3
CONHCONH 2
Me
CF 3
2
5-0219.
1
3-CF 3
CONHCONHMe
Me
CF 3
0
5-0220.
1
3-CF 3
CON(Me)CONH 2
Me
CF 3
0
5-0221.
1
3-CF 3
CON(Me)CONH 2
Me
CF 3
2
5-0222.
1
3-CF 3
CON(Me)CONHMe
Me
CF 3
0
5-0223.
1
3-CF 3
CON(Me)CONHMe
Me
CF 3
2
5-0224.
1
3-CF 3
CN
H
CF 3
0
5-0225.
1
3-CF 3
CN
Me
CF 3
0
5-0226.
1
3-CF 3
CN
Me
CF 3
1
5-0227.
1
3-CF 3
CN
Me
CF 3
2
5-0228.
1
3-CF 3
CHO
Me
CF 3
0
5-0229.
1
3-CF 3
Ac
H
CF 3
0
5-0230.
1
3-CF 3
Ac
Me
CF 3
0
5-0231.
1
3-CF 3
Ac
Me
CF 3
1
5-0232.
1
3-CF 3
Ac
Me
CF 3
2
5-0233.
1
3-CF 3
CO—i-Pr
Me
CF 3
0
5-0234.
1
3-CF 3
CO—t-Bu
Me
CF 3
0
5-0235.
1
3-CF 3
CO—t-Bu
Me
CF 3
1
5-0236.
1
3-CF 3
CO—t-Bu
Me
CF 3
2
5-0237.
1
3-CF 3
CH═N—OH
Me
CF 3
0
5-0238.
1
3-CF 3
CH═N—OH
Me
CF 3
1
5-0239.
1
3-CF 3
CH═N—OH
Me
CF 3
2
5-0240.
1
3-CF 3
CH═N—OMe
Me
CF 3
0
5-0241.
1
3-CF 3
CH═N—OMe
Me
CF 3
1
5-0242.
1
3-CF 3
CH═N—OMe
Me
CF 3
2
5-0243.
1
3-CF 3
C(Me)═N—OH
Me
CF 3
0
5-0244.
1
3-CF 3
C(Me)═N—OH
Me
CF 3
1
5-0245.
1
3-CF 3
C(Me)═N—OH
Me
CF 3
2
5-0246.
1
3-CF 3
C(Me)═N—OMe
H
CF 3
0
5-0247.
1
3-CF 3
C(Me)═N—OMe
H
CF 3
1
5-0248.
1
3-CF 3
C(Me)═N—OMe
H
CF 3
2
5-0249.
1
3-CF 3
C(Me)═N—i-Pr
Me
CF 3
0
5-0250.
1
3-CF 3 -5-Me
COO—t-Bu
H
CF 3
0
5-0251.
1
3-CF 3 -5-Me
COO—t-Bu
H
CF 3
1
5-0252.
1
3-CF 3 -5-Me
COO—t-Bu
H
CF 3
2
5-0253.
1
3-CF 3 -5-Me
COO—t-Bu
Me
CF 3
0
5-0254.
1
3-CF 3 -5-Me
COO—t-Bu
Me
CF 3
1
5-0255.
1
3-CF 3 -5-Me
COO—t-Bu
Me
CF 3
2
5-0256.
1
3-CF 3 -5-CF 3
COO—t-Bu
H
CF 3
0
5-0257.
1
3-CF 3 -5-CF 3
COO—t-Bu
H
CF 3
1
5-0258.
1
3-CF 3 -5-CF 3
COO—t-Bu
H
CF 3
2
5-0259.
1
3-CF 3 -5-CF 3
COO—t-Bu
Me
CF 3
0
5-0260.
1
3-CF 3 -5-CF 3
COO—t-Bu
Me
CF 3
1
5-0261.
1
3-CF 3 -5-CF 3
COO—t-Bu
Me
CF 3
2
5-0262.
1
3-CF 3 -5-NH 2
COO—t-Bu
H
CF 3
0
5-0253.
1
3-CF 3 -5-NH 2
COO—t-Bu
H
CF 3
2
5-0264.
1
3-CF 3 -5-NH 2
COO—t-Bu
Me
CF 3
0
5-0265.
1
3-CF 3 -5-NH 2
COO—t-Bu
Me
CF 3
2
5-0266.
1
3-CF 3 -5-NMe 2
COO—t-Bu
Me
CF 3
0
5-0267.
1
3-CF 3 -5-NMe 2
COO—t-Bu
Me
CF 3
2
5-0268.
1
3-CF 3 -5-NHAc
COO—t-Bu
Me
CF 3
0
5-0269.
1
3-CF 3 -5-NHAc
COO—t-Bu
Me
CF 3
2
5-0270.
1
3-CF 3 -5-SMe
COOEt
H
CF 3
0
5-0271.
1
3-CF 3 -5-SMe
COOEt
H
CF 3
1
5-0272.
1
3-CF 3 -5-SMe
COOEt
Me
CF 3
0
5-0273.
1
3-CF 3 -5-SMe
COOEt
Me
CF 3
1
5-0274.
1
3-CF 3 -5-SO 2 Me
COOEt
Me
CF 3
2
5-0275.
1
3-CF 3 -5-SMe
COO—i-Pr
Me
CF 3
0
5-0276.
1
3-CF 3 -5-SO 2 Me
COO—i-Pr
Me
CF 3
2
5-0277.
1
3-CF 3 -5-SMe
COO—t-Bu
H
CF 3
0
5-0278.
1
3-CF 3 -5-SO 2 Me
COO—t-Bu
H
CF 3
2
5-0279.
1
3-CF 3 -5-SMe
COO—i-Bu
Me
CF 3
0
5-0280.
1
3-CF 3 -5-SO 2 Me
COO—i-Bu
Me
CF 3
2
5-0281.
1
3-CF 3 -5-SMe
COO—s-Bu
Me
CF 3
0
5-0282.
1
3-CF 3 -5-SO 2 Me
COO—s-Bu
Me
CF 3
2
5-0283.
1
3-CF 3 -5-SMe
CO 2 CH 2 CH 2 OMe
H
CF 3
0
5-0284.
1
3-CF 3 -5-SMe
CO 2 CH 2 CH 2 OMe
Me
CF 3
0
5-0285.
1
3-CF 3 -5-SO 2 Me
CO 2 CH 2 CH 2 OMe
Me
CF 3
2
5-0286.
1
3-CF 3 -5-SMe
CO 2 CH 2 CONH 2
H
CF 3
0
5-0287.
1
3-CF 3 -5-SMe
CO 2 CH 2 CONH 2
Me
CF 3
0
5-0288.
1
3-CF 3 -5-SO 2 Me
CO 2 CH 2 CONH 2
Me
CF 3
2
5-0289.
1
3-CF 3 -5-SO 2 Me
Me
H
CF 3
2
5-0290.
1
3-CF 3 -5-SMe
Ac
H
CF 3
0
5-0291.
1
3-CF 3 -5-SMe
Ac
Me
CF 3
0
5-0292.
1
3-CF 3 -5-SO 2 Me
Ac
Me
CF 3
2
5-0293.
1
3-CF 3 -5-SEt
COO—t-Bu
H
CF 3
0
5-0294.
1
3-CF 3 -5-SEt
COO—t-Bu
Me
CF 3
0
5-0295.
1
3-CF 3 -5-SO 2 Et
COO—t-Bu
Me
CF 3
2
5-0296.
1
3-CF 3 -5-S—Pr
COOEt
H
CF 3
0
5-0297.
1
3-CF 3 -5-S—Pr
COOEt
Me
CF 3
0
5-0298.
1
3-CF 3 -5-SO 2 —Pr
COOEt
Me
CF 3
2
5-0299.
1
3-CF 3 -5-SO 2 —Pr
Me
H
CF 3
2
5-0300.
1
3-CF 3 -5-S—i-Pr
COOEt
H
CF 3
0
5-0301.
1
3-CF 3 -5-S—i-Pr
COOEt
Me
CF 3
0
5-0302.
1
3-CF 3 -5-SO 2 —i-Pr
COOEt
Me
CF 3
2
5-0303.
1
3-CF 3 -5-SO 2 —i-Pr
Me
H
CF 3
2
5-0304.
1
3-CF 3 -5-S—Bu
COOMe
H
CF 3
0
5-0305.
1
3-CF 3 -5-S—Bu
COOMe
Me
CF 3
0
5-0306.
1
3-CF 3 -5-SO 2 —Bu
COOMe
Me
CF 3
2
5-0307.
1
3-CF 3 -5-S—i-Bu
COOMe
H
CF 3
0
5-0308.
1
3-CF 3 -5-S—i-Bu
COOMe
Me
CF 3
0
5-0309.
1
3-CF 3 -5-SO 2 —i-Bu
COOMe
Me
CF 3
2
5-0310.
1
3-CF 3 -5-S—s-Bu
COOMe
H
CF 3
0
5-0311.
1
3-CF 3 -5-S—s-Bu
COOMe
Me
CF 3
0
5-0312.
1
3-CF 3 -5-SO 2 —s-Bu
COOMe
Me
CF 3
2
5-0313.
1
3-CF 3 -5-S—c-Pen
COOMe
H
CF 3
0
5-0314.
1
3-CF 3 -5-S—c-Pen
COOMe
Me
CF 3
0
5-0315.
1
3-CF 3 -5-SO 2 —c-Pen
COOMe
Me
CF 3
2
5-0316.
1
3-CF 3 -5-SCH 2 —c-Pr
COOMe
H
CF 3
0
5-0317.
1
3-CF 3 -5-SCH 2 —c-Pr
COOMe
Me
CF 3
0
5-0318.
1
3-CF 3 -5-SO 2 CH 2 —c-Pr
COOMe
Me
CF 3
2
5-0319.
1
3-CF 3 -5-SCH 2 CF 3
COOEt
H
CF 3
0
5-0320.
1
3-CF 3 -5-SCH 2 CF 3
COOEt
Me
CF 3
0
5-0321.
1
3-CF 3 -5-SCH 2 CF 3
COOEt
Me
CF 3
1
5-0322.
1
3-CF 3 -5-SOCH 2 CF 3
COOEt
Me
CF 3
2
5-0323.
1
3-CF 3 -5-S(CH 2 ) 2 CF 3
COOMe
Me
CF 3
0
5-0324.
1
3-CF 3 -5-SO 2 (CH 2 ) 2 CF 3
COOMe
Me
CF 3
2
5-0325.
1
3-CF 3 -5-S(CH 2 ) 2 OMe
COOEt
H
CF 3
0
5-0326.
1
3-CF 3 -5-SO 2 (CH 2 ) 2 OMe
COOEt
H
CF 3
2
5-0327.
1
3-CF 3 -5-S(CH 2 ) 2 OMe
COOEt
Me
CF 3
0
5-0328.
1
3-CF 3 -5-SO 2 (CH 2 ) 2 OMe
COOEt
Me
CF 3
2
5-0329.
1
3-CF 3 -5-S(CH 2 ) 2 OEt
COOMe
H
CF 3
0
5-0330.
1
3-CF 3 -5-S(CH 2 ) 2 OEt
COOMe
Me
CF 3
0
5-0331.
1
3-CF 3 -5-SO 2 (CH 2 ) 2 OEt
COOMe
Me
CF 3
2
5-0332.
1
3-CF 3 -5-S(CH 2 ) 2 O(CH 2 ) 2 OMe
COOEt
H
CF 3
0
5-0333.
1
3-CF 3 -5-S(CH 2 ) 2 O(CH 2 ) 2 OMe
COOEt
Me
CF 3
0
5-0334.
1
3-CF 3 -5-SO 2 (CH 2 ) 2 O(CH 2 ) 2 OMe
COOEt
Me
CF 3
2
5-0335.
1
3-CF 3 -5-SCH 2 —E 1
COOEt
H
CF 3
0
5-0336.
1
3-CF 3 -5-SCH 2 —E 1
COOEt
Me
CF 3
0
5-0337.
1
3-CF 2 -5-SO 2 CH 2 —E 1
COOEt
Me
CF 3
2
5-0338.
1
3-CF 3 -5-SCH 2 Ph
COOEt
H
CF 3
0
5-0339.
1
3-CF 3 -5-SO 2 CH 2 Ph
COOEt
H
CF 3
2
5-0340.
1
3-CF 2 -5-SCH 2 Ph
COOEt
Me
CF 3
0
5-0341.
1
3-CF 2 -5-SO 2 CH 2 Ph
COOEt
Me
CF 3
2
5-0342.
1
3-CF 3 -5-F
COOMe
H
CF 3
0
5-0343.
1
3-CF 3 -5-F
COOMe
H
CF 3
2
5-0344.
1
3-CF 3 -5-F
COOMe
Me
CF 3
0
5-0345.
1
3-CF 3 -5-F
COOMe
Me
CF 3
2
5-0346.
1
3-CF 3 -5-Cl
COOMe
H
CF 3
0
5-0347.
1
3-CF 3 -5-Cl
COOMe
H
CF 3
2
5-0348.
1
3-CF 3 -5-Cl
COOMe
Me
CF 3
0
5-0349.
1
3-CF 3 -5-Cl
COOMe
Me
CF 3
2
5-0350.
1
3-CF 3 -5-Br
COOMe
H
CF 3
0
5-0351.
1
3-CF 3 -5-Br
COOMe
H
CF 3
2
5-0352.
1
3-CF 3 -5-Br
COOMe
Me
CF 3
0
5-0353.
1
3-CF 3 -5-Br
COOMe
Me
CF 3
2
5-0354.
1
3-CF 3 -5-COOEt
COO—t-Bu
H
CF 3
0
5-0355.
1
3-CF 3 -5-COOEt
COO—t-Bu
Me
CF 3
0
5-0356.
1
3-CF 3 -5-COOEt
COO—t-Bu
Me
CF 3
2
5-0357.
1
3-CF 3 -5-CN
COO—t-Bu
H
CF 3
0
5-0358.
1
3-CF 3 -5-CN
COO—t-Bu
Me
CF 3
0
5-0359.
1
3-CF 3 -5-CN
COO—t-Bu
Me
CF 3
2
5-0360.
1
3-t-Bu
Me
H
CF 3
0
5-0361.
1
3-t-Bu
Me
H
CF 3
1
5-0362.
1
3-t-Bu
Me
H
CF 3
2
5-0363.
1
3-t-Bu
COOH
Me
CF 3
0
5-0364.
1
3-t-Bu
COOMe
H
CF 3
0
5-0365.
1
3-t-Bu
COOMe
Me
CF 3
0
5-0366.
1
3-t-Bu
COOMe
Me
CF 3
2
5-0367.
1
3-t-Bu
COOEt
Me
CF 3
0
5-0368.
1
3-t-Bu
COOEt
Me
CF 3
2
5-0369.
1
3-t-Bu
COO—i-Pr
Me
CF 3
0
5-0370.
1
3-t-Bu
COO—i-Pr
Me
CF 3
2
5-0371.
1
3-t-Bu
COOCH 2 CH 2 OMe
Me
CF 3
0
5-0372.
1
3-t-Bu
COOCH 2 CH 2 OMe
Me
CF 3
2
5-0373.
1
3-t-Bu
COOCH 2 CONH 2
Me
CF 3
0
5-0374.
1
3-t-Bu
COOCH 2 CONH 2
Me
CF 3
2
5-0375.
1
3-t-Bu
COO—t-Bu
H
CF 3
0
5-0376.
1
3-t-Bu
COO—t-Bu
H
CF 3
1
5-0377.
1
3-t-Bu
COO—t-Bu
H
CF 3
2
5-0378.
1
3-t-Bu
COO—t-Bu
Me
CF 3
0
5-0379.
1
3-t-Bu
COO—t-Bu
Me
CF 3
1
5-0380.
1
3-t-Bu
COO—t-Bu
Me
CF 3
2
5-0381.
1
3-t-Bu-5-SMe
COO—t-Bu
Me
CF 3
0
5-0382.
1
3-t-Bu-5-SO 2 Me
COO—t-Bu
Me
CF 3
2
5-0383.
1
3-t-Bu-5-F
COOEt
H
CF 3
0
5-0384.
1
3-t-Bu-5-F
COOEt
H
CF 3
2
5-0385.
1
3-t-Bu-5-F
COOEt
Me
CF 3
0
5-0386.
1
3-t-Bu-5-F
COOEt
Me
CF 3
2
5-0387.
1
3-t-Bu-5-Cl
COOEt
H
CF 3
0
5-0388.
1
3-t-Bu-5-Cl
COOEt
H
CF 3
2
5-0389.
1
3-t-Bu-5-Cl
COOEt
Me
CF 3
0
5-0390.
1
3-t-Bu-5-Cl
COOEt
Me
CF 3
2
5-0391.
1
3-t-Bu-5-Br
COOEt
H
CF 3
0
5-0392.
1
3-t-Bu-5-Br
COOEt
H
CF 3
2
5-0393.
1
3-t-Bu-5-Br
COOEt
Me
CF 3
0
5-0394.
1
3-t-Bu-5-Br
COOEt
Me
CF 3
2
5-0395.
1
3-c-Pr
COO—t-Bu
H
CF 3
0
5-0396.
1
3-c-Pr
COO—t-Bu
H
CF 3
1
5-0397.
1
3-c-Pr
COO—t-Bu
H
CF 3
2
5-0398.
1
3-c-Pr
COO—t-Bu
Me
CF 3
0
5-0399.
1
3-c-Pr
COO—t-Bu
Me
CF 3
1
5-0400.
1
3-c-Pr
COO—t-Bu
Me
CF 3
2
5-0401.
1
5-c-Pr
COO—t-Bu
Me
CF 3
2
5-0402.
1
3-CHF 2
COOEt
H
CF 3
0
5-0403.
1
3-CHF 2
COOEt
H
CF 3
1
5-0404.
1
3-CHF 2
COOEt
H
CF 3
2
5-0405.
1
3-CHF 2
COOEt
Me
CF 3
0
5-0406.
1
3-CHF 2
COOEt
Me
CF 3
1
5-0407.
1
3-CHF 2
COOEt
Me
CF 3
2
5-0408.
1
3-CF 2 CF 3
COO—t-Bu
H
CF 3
0
5-0409.
1
3-CF 2 CF 3
COO—t-Bu
H
CF 3
1
5-0410.
1
3-CF 2 CF 3
COO—t-Bu
H
CF 3
2
5-0411.
1
3-CF 2 CF 3
COO—t-Bu
Me
CF 3
0
5-0412.
1
S-CF 2 CF 3
COO—t-Bu
Me
CF 3
1
5-0413.
1
3-CF 2 CF 3
COO—t-Bu
Me
CF 3
2
5-0414.
1
3-CF 2 CF 3
Me
H
CF 3
0
5-0415.
1
S-CF 2 CF 3
Me
H
CF 3
1
5-0416.
1
3-CF 2 CF 3
Me
H
CF 3
2
5-0417.
1
3-CH(CF 3 ) 2
COO—t-Bu
H
CF 3
0
5-0418.
1
3-CH(CF 3 ) 2
COO—t-Bu
H
CF 3
1
5-0419.
1
3-CH(CF 3 ) 2
COO—t-Bu
H
CF 3
2
5-0420.
1
3-CH(CF 3 ) 2
COO—t-Bu
Me
CF 3
0
5-0421.
1
3-CH(CF 3 ) 2
COO—t-Bu
Me
CF 3
1
5-0422.
1
3-CH(CF 3 ) 2
COO—t-Bu
Me
CF 3
2
5-0423.
1
3-CH(CF 3 ) 2
Me
H
CF 3
0
5-0424.
1
3-CH(CF 3 ) 2
Me
H
CF 3
1
5-0425.
1
3-CH(CF 3 ) 2
Me
H
CF 3
2
5-0426.
1
—
COO—t-Bu
H
CF 3
0
5-0427.
1
—
COO—t-Bu
H
CF 3
1
5-0428.
1
—
COO—t-Bu
H
CF 3
2
5-0429.
1
—
COO—t-Bu
Me
CF 3
0
5-0430.
1
—
COO—t-Bu
Me
CF 3
1
5-0431.
1
—
COO—t-Bu
Me
CF 3
2
5-0432.
1
3-NO 2
COO—t-Bu
Me
CF 3
0
5-0433.
1
3-NO 2
COO—t-Bu
Me
CF 3
1
5-0434.
1
3-NO 2
COO—t-Bu
Me
CF 3
2
5-0435.
1
3-NHAc
COO—t-Bu
Me
CF 3
0
5-0436.
1
3-NHAc
COO—t-Bu
Me
CF 3
1
5-0437.
1
3-NHAc
COO—t-Bu
Me
CF 3
2
5-0438.
1
3-SCF 3
COO—t-Bu
H
CF 3
0
5-0439.
1
3-SCF 3
COO—t-Bu
Me
CF 3
0
5-0440.
1
3-SOCF 3
COO—t-Bu
Me
CF 3
2
5-0441.
1
3-SMe
COO—t-Bu
H
CF 3
0
5-0442.
1
3-SMe
COO—t-Bu
Me
CF 3
0
5-0443.
1
3-SO 2 Me
Me
H
CF 3
2
5-0444.
1
3,5-(SMe) 2
COO—t-Bu
H
CF 3
0
5-0445.
1
3,5-(SO 2 Me) 2
COO—t-Bu
H
CF 3
2
5-0446.
1
3,5-(SMe) 2
COO—t-Bu
Me
CF 3
0
5-0447.
1
3,5-(SO 2 Me) 2
COO—t-Bu
Me
CF 3
2
5-0448.
1
3-SMe-5-CF 2
COOEt
H
CF 3
0
5-0449.
1
3-SMe-5-CF 3
COOEt
Me
CF 3
0
5-0450.
1
3-SO 2 Me-5-CF 3
COOEt
Me
CF 3
2
5-0451.
1
3-SO 2 Me-5-CF 3
Me
H
CF 3
2
5-0452.
1
3-SEt-5-CF 3
COO—t-Bu
Me
CF 3
0
5-0453.
1
3-SO 2 Et-5-CF 3
COO—t-Bu
Me
CF 3
2
5-0454.
1
3-SO 2 Et-5-CF 3
Me
H
CF 3
2
5-0455.
1
3-S—Pr-5-CF 3
COO—t-Bu
Me
CF 3
0
5-0456.
1
3-SO 2 —Pr-5-CF 3
COO—t-Bu
Me
CF 3
2
5-0457.
1
3-SO 2 —Pr-5-CF 3
Me
H
CF 3
2
5-0458.
1
3-SO 2 (CH 2 ) 2 CF 3 -5-CF 3
COOMe
Me
CF 3
2
5-0459.
1
3-SO 2 (CH 2 ) 2 CF 3 -5-CF 3
Me
H
CF 3
2
5-0460.
1
3-COOEt-5-CF 3
COO—t-Bu
H
CF 3
0
5-0461.
1
3-COOEt-5-CF 3
COO—t-Bu
H
CF 3
2
5-0462.
1
3-COOEt-5-CF 3
COO—t-Bu
Me
CF 3
0
5-0463.
1
3-COOEt-5-CF 3
COO—t-Bu
Me
CF 3
2
5-0464.
3
1-Me-5-CF 3
H
H
CF 3
0
5-0465.
3
1-Me-5-CF 3
H
H
CF 3
1
5-0466.
3
1-Me-5-CF 3
H
H
CF 3
2
5-0467.
3
1-Me-5-CF 3
Me
H
CF 3
0
5-0468.
3
1-Me-5-CF 3
Me
H
CF 3
1
5-0469.
3
1-Me-5-CF 3
Me
H
CF 3
2
5-0470.
5
1-Me-3-CF 3
H
H
CF 3
0
5-0471.
5
1-Me-3-CF 3
H
H
CF 3
1
5-0472.
5
1-Me-5-CF 3
H
H
CF 3
2
5-0473.
5
1-Me-5-CF 3
Me
H
CF 3
0
5-0474.
5
1-Me-3-CF 3
Me
H
CF 3
1
5-0475.
5
1-Me-3-CF 3
Me
H
CF 3
2
5-0476.
5
1-Me-3-CF 3
Me
Me
CF 3
2
5-0477.
1
3-CF 3 -5-COOEt
COO—t-Bu
H
CF 3
2
5-0478.
1
3-CF 3 -5-SCH 2 CH═CH 2
COOMe
H
CF 3
0
5-0479.
1
3-CF 3 -5-SCH 2 CH═CH 2
COOMe
Me
CF 3
0
5-0480.
1
3-CF 3 -5-SO 2 CH 2 CH═CH 2
COOMe
Me
CF 3
2
5-0481.
1
3-CF 3 -5-SCH 2 CH═CHCl
COOMe
H
CF 3
0
5-0482.
1
3-CF 3 -5-SCH 2 CH═CHCl
COOMe
Me
CF 3
0
5-0483.
1
3-CF 3 -5-SO 2 CH 2 CH═CHCl
COOMe
Me
CF 3
2
5-0484.
1
3-CF 3 -5-SCH 2 CH═CH
COOMe
H
CF 3
0
5-0485.
1
3-CF 3 -5-SCH 2 CH═CH
COOMe
Me
CF 3
0
5-0486.
1
3-CF 3 -5-SO 2 CH 2 CH═CH
COOMe
Me
CF 3
2
wherein m is 0 or 1;
Position in Table 5 is the position on the 1,2,4-triazolyl group which is substituted by the moiety
V, R 1 , R 2 , and n are defined in Table 5;
R 3U is CF 3 or CF 2 H; and
E 1 , E 2 , E 3 , E 4 , E 6 and E 7 are the following structures:
18. A compound of formula 6-xxxx, selected from Table 6:
TABLE 6
6-xxxx
No.
Position
V
R 1
R 2
R 3U
n
6-01.
2
4-CF 3
H
H
CF 3
0
6-02.
2
4-CF 3
H
H
CF 3
1
6-03.
2
4-CF 3
H
H
CF 3
2
6-04.
2
4-CF 3
Me
H
CF 3
0
6-05.
2
4-CF 3
Me
H
CF 3
1
6-06.
2
4-CF 3
Me
H
CF 3
2
6-07.
2
4-CF 3
Me
F
CF 3
2
6-08.
2
4-CF 3
Me
Cl
CF 3
2
6-09.
2
4-CF 3
Me
CH 2 CH 2 Cl
CF 3
2
6-010.
2
4-CF 3
Me
CH 2 OMe
CF 3
2
6-011.
2
4-CF 3
Me
CH 2 CH 2 OMe
CF 3
2
6-012.
2
4-CF 3
Me
CH 2 OH
CF 3
2
6-013.
2
4-CF 3
Me
CH 2 F
CF 3
2
6-048.
5
2-CF 3
Me
H
CF 3
2
6-049.
5
2-CF 3
Me
Me
CF 3
2
6-050.
5
2-CF 3
Et
H
CF 3
2
6-051.
5
2-CF 3
Et
Et
CF 3
2
6-052.
5
2-CF 3
i-Pr
H
CF 3
2
6-053.
5
2-CF 3
Pr
H
CF 3
2
6-054.
5
2-CF 3
Pr
Pr
CF 3
2
6-065.
5
2-CF 3
s-Bu
H
CF 3
2
6-056.
5
2-CF 3
i-Bu
H
CF 3
2
6-057.
5
2-CF 3
Bu
H
CF 3
2
6-058.
5
2-CF 3
CH 2 —c-Pr
H
CF 3
2
6-059.
5
2-CF 3
CH 2 CH═CH 2
H
CF 3
2
6-060.
5
2-CF 3
CH 2 CH═CH 2
CH 2 CH═CH 2
CF 3
2
6-061.
5
2-CF 3
CH 2 C≡CH
H
CF 3
2
6-062.
5
2-CF 3
CH 2 C≡CH
CH 2 C≡CH
CF 3
2
6-063.
5
2-CF 3
CH 2 C(Cl)═CH 2
H
CF 3
2
6-064.
5
2-CF 3
F
H
CF 3
2
6-065.
5
2-CF 3
F
F
CF 3
2
6-066.
5
2-CF 3
Cl
H
CF 3
2
6-067.
5
2-CF 3
Cl
Cl
CF 3
2
6-068.
5
2-CF 3
COOMe
H
CF 3
2
6-069.
5
2-CF 3
COOEt
H
CF 3
2
6-070.
5
2-CF 3
CH 2 CN
H
CF 3
2
6-071.
5
2-CF 3
CH 2 COOMe
H
CF 3
2
6-072.
5
2-CF 3
CONH 2
H
CF 3
2
6-073.
5
2-CF 3
CONHEt
H
CF 3
2
6-074.
5
2-CF 3
CSNHMe
H
CF 3
2
6-075.
5
2-CF 3
CON(Me) 2
H
CF 3
2
6-076.
5
2-CF 3
CHO
H
CF 3
2
6-077.
5
2-CF 3
Ac
H
CF 3
2
6-078.
5
2-CF 3
COEt
H
CF 3
2
6-079.
5
2-CF 3
CO—i-Pr
H
CF 3
2
6-080.
5
2-CF 3
COCH 2 Cl
H
CF 3
2
6-081.
5
2-CF 3
—CH 2 —CH 2 —
CF 3
2
6-082.
5
2-CF 3
—CH 2 —CH 2 —CH 2 —
CF 3
2
6-083.
5
2-CF 3
—CH 2 —CH 2 —CH 2 —CH 2 —
CF 3
2
6-084.
5
2-CF 3
═CH—N(Me) 2
CF 3
2
6-085.
5
2-CF 3
═CH—NHMe
CF 3
2
6-086.
5
2-CF 3
═CH—NH 2
CF 3
2
6-087.
5
2-CF 3
CF 3
2
6-088.
5
2-CF 3
═CH—OMe
CF 3
2
6-089.
5
2-CF 3
═CH—OEt
CF 3
2
6-090.
5
2-CF 3
═C(Me)—OEt
CF 3
2
6-091.
5
2-CF 3
═N—OH
2-CF 3
0
6-092.
5
2-CF 3
═N—OMe
2-CF 3
0
6-093.
5
2-CF 3
═N—OMe
2-CF 3
1
6-094.
5
2-CF 3
═N—OMe
2-CF 3
2
6-095.
5
2-CF 3
═N—OEt
2-CF 3
0
6-096.
5
2-CF 3
═N—OEt
2-CF 3
1
6-097.
5
2-CF 3
═N—OEt
2-CF 3
2
6-098.
5
2-CF 3
H
H
CF 2 CF 3
0
6-099.
5
2-CF 3
H
H
CF 2 CF 3
1
6-0100.
5
2-CF 3
H
H
CF 2 CF 3
2
6-0101.
5
2-CF 3
H
H
CF 2 CF 2 CF 3
0
6-0102.
5
2-CF 3
H
H
CF 2 CF 2 CF 3
1
6-0103.
5
2-CF 3
H
H
CF 2 CF 2 CF 3
2
6-0104.
5
2-CF 3 -4-Me
H
H
CF 3
0
6-0105.
5
2-CF 3 -4-Me
H
H
CF 3
1
6-0106.
5
2-CF 3 -4-Me
H
H
CF 3
2
6-0107.
5
2-CF 3 -4-Me
Me
H
CF 3
2
6-0108.
5
2-Cl
H
H
CF 3
0
6-0109.
5
2-Cl
H
H
CF 3
1
6-0110.
5
2-Cl
H
H
CF 3
2
6-0111.
5
2-Cl
Me
H
CF 3
2
6-0112.
5
2-Cl
H
H
CF 3
0
6-0113.
5
2-Cl
H
H
CF 3
1
6-0114.
5
2-Cl
H
H
CF 3
2
6-0115.
5
2-Cl
H
H
CF 2 CF 2 CF 3
0
6-0116.
5
2-Cl
H
H
CF 2 CF 2 CF 3
1
6-0117.
5
2-Cl
H
H
CF 2 CF 2 CF 3
2
6-0118.
5
2-Me
H
H
CF 3
0
6-0119.
5
2-Me
H
H
CF 3
1
6-0120.
5
2-Me
H
H
CF 3
2
6-0121.
5
2-Et
H
H
CF 3
0
6-0122.
5
2-Et
H
H
CF 3
1
6-0123.
5
2-Et
H
H
CF 3
2
6-0124.
5
2-i-Pr
H
H
CF 3
0
6-0125.
5
2-i-Pr
H
H
CF 3
1
6-0126.
5
2-i-Pr
H
H
CF 3
2
6-0127.
5
2-c-Pr
H
H
CF 3
0
6-0128.
5
2-c-Pr
H
H
CF 3
1
6-0129.
5
2-c-Pr
H
H
CF 3
2
6-0130.
5
2-t-Bu
H
H
CF 3
0
6-0131.
5
2-t-Bu
H
H
CF 3
1
6-0132.
5
2-t-Bu
H
H
CF 3
2
6-0133.
4
2-CF 3
Me
H
CF 3
2
wherein m is 0 or 1;
Position in Table 6 is the position on the thiazolyl group which is substituted by the moiety
V, R 1 , R 2 , and n are defined in Table 6; and
R 3U is as defined in Table 6 or CF 2 H.
19. An agricultural composition comprising at least one compound of any one of claims 1 , 16 , 17 or 18 and at least one agriculturally acceptable carrier.
20. A veterinary composition comprising at least one compound of any one of claim 1 , 16 , 17 or 18 and at least one veterinarily acceptable carrier.
21. A method for controlling invertebrate pests which method comprises treating the pests, their food supply, their habitat or their breeding ground or a plant, plant propagation material, soil, area, material or environment in which the pests are growing or may grow, or the materials, plants, plant propagation material, soils, surfaces or spaces to be protected from invertebrate pest attack or infestation with a pesticidally effective amount of at least one compound of any one of claim 1 , 16 , 17 or 18 .
22. A method for protecting plants from attack or infestation by invertebrate pests, which method comprises treating the plants with a pesticidally effective amount of at least one compound of any one of claim 1 , 16 , 17 or 18 .
23. A method for protecting plant propagation material or the plants which grow therefrom from attack or infestation by invertebrate pests, which method comprises treating the plant propagation material with a pesticidally effective amount of at least one compound of any one of claim 1 , 16 , 17 or 18 .
24. Plant propagation material, comprising at least one compound of any one of claim 1 , 16 , 17 or 18 .
25. A method for treating, controlling, preventing or protecting an animal from infestation or infection by invertebrate pests which comprises bringing the animal in contact with a pesticidally effective amount of at least one compound of any one of claim 1 , 16 , 17 or 18 .