Targeting monomers and polymers having targeting blocks

1. A monomer of Formula M1

wherein

M 1 and M 2 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclo, and substituted carbonyl, provided, however, M 1 and M 2 are not each selected from the group consisting of aryl, heteroaryl, and heterosubstituted carbonyl;

M 3 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclo, or substituted carbonyl, and

M 4 is —C(O)OM 40 , —C(O)SM 40 , —C(O)NM 40 M 41 , —Ar-M 40 or -Het-M 40 , Ar is arylene, Het is heteroarylene, M 41 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, substituted heterohydrocarbyl, or heterocyclo, and M 40 contains, as a terminal moiety, a targeting moiety selected from the group consisting of folate and folate analogs, provided M 3 and M 4 are not each selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, and heterosubstituted carbonyl.

2. The monomer of claim 1 wherein M 3 is hydrogen, methyl, ethyl, or propyl.

3. The monomer of claim 1 wherein M 40 is a substituted hydrocarbyl or a substituted heterohydrocarbyl containing the terminal targeting moiety.

4. The monomer of claim 1 wherein M 3 is hydrogen, methyl, ethyl, or propyl; and M 40 is a substituted hydrocarbyl or a substituted heterohydrocarbyl containing the terminal targeting moiety.

5. The monomer of claim 1 wherein M 3 is hydrogen, methyl, ethyl, or propyl; and M 4 is —C(O)OM 40 , —C(O)SM 40 , or —C(O)NM 40 M 41 .

6. The monomer of claim 1 wherein M 40 contains, as the terminal targeting moiety, a moiety having the formula

wherein the symbol, , designates the point of attachment of the targeting moiety to the remainder of M 40 , T 4 is hydroxy, optionally substituted alkoxy, or amino, T 5 is hydrogen or alkyl, and T 6 is hydrogen or optionally substituted alkyl.

7. A monomer of Formula M10

wherein M 3 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclo, or substituted carbonyl; Y is a bond or a linking group selected from the group consisting of hydrocarbylene, substituted hydrocarbylene, heterohydrocarbyl, and substituted heterohydrocarbyl; T 4 is hydroxy, optionally substituted alkoxy, or amino; T 5 is hydrogen or alkyl, T 6 is hydrogen, alkyl, substituted alkyl, heterohydrocarbyl, or substituted heterohydrocarbyl; Z is —C(O)O—, —C(O)S—, —C(O)N(M 41 )-, —Ar-M 49 - or Het-M 49 -; Ar is arylene; Het is heteroarylene; M 41 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, substituted heterohydrocarbyl, or heterocyclo; M 49 is oxygen, sulfur, or —N(M 50 )-; and M 50 is hydrogen, hydrocarbyl or substituted hydrocarbyl.

8. The monomer of claim 7 wherein M 3 is hydrogen, methyl, ethyl, or propyl, T 4 is hydroxy, and T 5 and T 6 are hydrogen.

9. The monomer of claim 7 wherein M 3 and T 6 are independently hydrogen, methyl, ethyl, or propyl; Z is —C(O)O—, —C(O)S—, or —C(O)N(M 41 )-; and M 41 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, substituted heterohydrocarbyl, or heterocyclo.

10. The monomer of claim 7 wherein Y is alkylene or (poly)alkylene oxide.

11. The monomer of claim 7 wherein M 3 and T 6 are independently hydrogen, methyl, ethyl, or propyl, Z is —C(O)O—, —C(O)S—, or —C(O)N(M 41 )-; Y is alkylene or (poly)alkylene oxide; and M 41 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, substituted heterohydrocarbyl, or heterocyclo.

12. The monomer of claim 7 wherein Z is —C(O)O— or —C(O)S— and the is of Formula M11 or M12

wherein M 3 is hydrogen, methyl, ethyl, or propyl, Y is a linking group selected from the group consisting of hydrocarbylene, substituted hydrocarbylene, heterohydrocarbyl, and substituted heterohydrocarbyl; T 4 is hydroxy, optionally substituted alkoxy, or amino; T 5 is hydrogen or alkyl, and T 6 is hydrogen, alkyl or substituted alkyl.

13. The monomer of claim 5 , wherein M 40 is a substituted hydrocarbyl or a substituted heterohydrocarbyl containing the terminal targeting moiety.