Pirfenidone therapy and inducers of cytochrome P450
View Patent ↗The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
1. A method of increasing the effectiveness of pirfenidone therapy by avoiding decreased exposure to pirfenidone, in a patient in need of pirfenidone therapy and taking a strong inducer of cytochrome P450 1A2 (CYP1A2), comprising administering to the patient a therapeutically effective amount of pirfenidone, and avoiding the strong inducer of a cytochrome P450 1A2 (CYP1A2).
2. The method of claim 1 , wherein the patient has idiopathic pulmonary fibrosis.
3. The method of claim 1 , wherein the patient suffers from a fibrosis condition.
4. The method of claim 1 , wherein the pirfenidone is administered at a total daily dosage of at least 1800 mg.
5. The method of claim 2 , wherein the pirfenidone is administered at a total daily dosage of at least 1800 mg.
6. The method of claim 1 , wherein the pirfenidone is administered at a total daily dosage of 2400 mg or 2403 mg.
7. The method of claim 2 , wherein the pirfenidone is administered at a total daily dosage of 2400 mg or 2403 mg.
8. The method of claim 1 , wherein each dose of pirfenidone administered is 801 mg.
9. The method of claim 6 , wherein pirfenidone is administered three times a day.
10. The method of claim 9 , wherein pirfenidone is administered with food.
11. The method of claim 1 , wherein the strong CYP1A2 inducer is cigarette smoke.
12. The method of claim 11 , wherein the patient has idiopathic pulmonary fibrosis.
13. The method of claim 11 , wherein the patient suffers from a fibrosis condition.
14. The method of claim 11 , wherein the pirfenidone is administered at a total daily dosage of at least 1800 mg.
15. The method of claim 12 , wherein the pirfenidone is administered at a total daily dosage of at least 1800 mg.
16. The method of claim 11 , wherein the pirfenidone is administered at a total daily dosage of 2400 mg or 2403 mg.
17. The method of claim 12 , wherein the pirfenidone is administered at a total daily dosage of 2400 mg or 2403 mg.
18. The method of claim 16 , wherein pirfenidone is administered three times a day.
19. The method of claim 18 , wherein pirfenidone is administered with food.