5-amino-4-hydroxypentoyl amides

1. A compound formula I:

wherein

R 1 is halo, C 1-4 alkoxy, trifluoromethoxy;

R 2 is a group of formula:

R 3 is a group of formula:

R 4 is a group of formula:

n is 0 or 1;

each A independently is CH or N;

R 5 and R 6 independently are hydrogen, C 1-4 alkyl, or halo;

R 7 is C 1-4 alkyl or C 1-4 alkoxyC 1-4 -alkyl;

R 8 is C 1-4 -alkyl or C 1-4 -alkoxyC 1-4 -alkyl;

each R 9 independently is C 1-4 alkyl, cyclopropyl, trifluoromethyl, C 1-4 alkoxy, or dimethylamino;

R 10 is hydrogen, C 1-4 alkyl, cyclopropyl, trifluoromethyl, C 1-4 alkoxy, or dimethylamino;

R 11 is hydrogen or C 1-4 alkyl;

the pharmaceutically acceptable addition salts and the pharmaceutically acceptable solvates thereof.

2. The compound of claim 1 wherein R 1 is halo or methoxy.

3. The compound of claim 1 wherein R 1 is fluoro or chloro; which fluoro or chloro is substituted in ortho position; or R 1 is methoxy; which methoxy is substituted in meta position.

4. The compound of any of claim 1 , wherein R 2 is a group of formula

5. The compound of claim 1 , wherein R 2 is a group of formula

6. The compound of claim 1 , wherein R 5 is hydrogen, and R 6 is halo or C 1-4 alkyl; R 5 is halo and R 6 is hydrogen; R 5 is halo or C 1-4 alkyl, and R 6 is hydrogen; or R 5 and R 6 are both hydrogen, or are both halo; R 11 is C 1-4 alkyl.

7. The compound of claim 1 , wherein R 5 is hydrogen and R 6 is fluoro or chloro; R 5 is fluoro or chloro and R 6 is hydrogen; R 5 is hydrogen and R 6 is methyl; R 5 and R 6 are both hydrogen, or R 5 is chloro and R 6 is fluoro; more in particular wherein R 5 is hydrogen and R 6 is fluoro; R 5 is chloro and R 6 is hydrogen; R 5 is hydrogen and R 6 is methyl; R 5 and R 6 are both hydrogen, or R 5 is chloro and R 6 is fluoro; and

R 11 is methyl.

8. The compound of any of claim 1 , wherein R 3 is a group of formula

9. The compound of any of claim 1 , wherein R 3 is a group of formula

10. The compound of claim 9 wherein R 8 is methyl or 2-methoxyethyl.

11. The compound of claim 1 wherein R 9 is C 1-2 alkoxy or dimethylamino.

12. The compound of any of claim 1 , wherein R 4 is a group having the chemical structure specified in claim 1 , but wherein in the first group R 9 is R 9a in the second group R 9 is R 9b in the third group R 9 is R 9c in the fourth group R 9 is R 9d in the fifth and in the sixth group R 9 is R 9e ; which groups can be represented as follows:

wherein each A independently is CH or N; or wherein each A is CH;

R 9a is C 1-4 alkoxy or dimethylamino;

R 9b is C 1-4 -alkoxy or dimethylamino;

R 9c is C 1-4 alkoxy or dimethylamino;

R 9d is C 1-4 alkyl, cyclopropyl, trifluoromethyl;

R 10 is hydrogen, C 1-4 alkyl, cyclopropyl, or trifluoromethyl; or R 10 is hydrogen, methyl, cyclopropyl, or trifluoromethyl;

each R 9e independently is C 1-4 alkyl, cyclopropyl, C 1-4 alkoxy, or dimethylamino.

13. The compound of claim 12 wherein in R 9a , R 9b , R 9c , R 9d , or R 9e C 1-4 alkoxy is methoxy and C 1-4 alkyl is methyl.

14. The compound of any of claim 1 wherein R 4 is:

wherein A is CH and R 9a is methoxy or dimethylamino.

15. The compound of claim 1 having the formula

16. The compound of claim 1 having the formula

17. The compound of claim 1 having the formula

18. A pharmaceutical composition comprising an effective amount of a compound of formula I as defined in claim 1 and a carrier.

19. A pharmaceutical composition comprising an effective amount of a compound of formula I as defined in claim 15 and a carrier.

20. A pharmaceutical composition comprising an effective amount of a compound of formula I as defined in claim 16 and a carrier.

21. A pharmaceutical composition comprising an effective amount of a compound of formula I as defined in claim 17 and a carrier.