Heteroarylcarboxylic acid ester derivative
Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
1. 3-[5-(4-amidino-2-fluorophenoxycarbonyl)thiophen-2-yl]-2,2-dimethylpropanoic acid:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof according to claim 1 and at least one pharmaceutically acceptable carrier or excipient.
3. N-[3-{5-(4-amidino-2-fluorophenoxycarbonyl)thiophen-2-yl}-2,2-dimethylpropanoyl]glycine:
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof according to claim 3 and at least one pharmaceutically acceptable carrier or excipient.
5. N-[3-{5-(4-amidino-2-fluorophenoxycarbonyl)thiophen-2-yl}-2,2-Dimethylpropanoyl]-L-serine:
or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof according to claim 5 and at least one pharmaceutically acceptable carrier or excipient.
7. N-allyl-N-[3-{5-(4-amidino-2-fluorophenoxycarbonyl)thiophen-2-yl}-2,2-dimethylpropanoyl]glycine:
or a pharmaceutically acceptable salt thereof.
8. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof according to claim 7 and at least one pharmaceutically acceptable carrier or excipient.