Cartridge interface assembly

1. A combination cartridge and cartridge interface assembly comprising:

a rotationally immobile cartridge ( 22 ) having an inner cylindrical surface, a first stopper ( 24 ) slidingly inserted in the cartridge ( 22 ), a distal end and a substance therein for administration to a subject; and

a cartridge interface assembly ( 80 ) comprising:

a driving plunger ( 82 ) comprising a first shaft ( 84 ), the driving plunger ( 82 ) having an abutting surface and one or more outer surfaces in contact with the inner cylindrical surface of the cartridge ( 22 );

a driver ( 86 ) comprising a gear wheel and a second shaft ( 88 ) rotatably fixed to the gear wheel, said second shaft ( 88 ) mating with said first shaft ( 84 ), so that said shafts are movable telescopically with respect to one another, wherein rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance in a direction away from said driver ( 86 ), the arrangement being such that on insertion of the cartridge interface assembly ( 80 ) in the rotationally immobile cartridge ( 22 ), the one or more outer surfaces of the driving plunger ( 82 ) and the inner cylindrical surface of the cartridge ( 22 ) have a frictional relationship such that it is easier for the driving plunger ( 82 ) to move linearly than rotate within the cartridge, wherein the frictional relationship is the only force impeding rotation of the driving plunger ( 82 ) with respect to the cartridge ( 22 ) such that rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance only towards the distal end until the abutting surface of the driving plunger ( 82 ) abuts against the stopper ( 24 ) whereupon the driving plunger ( 82 ) urges the stopper ( 24 ) towards the distal end for metering substance from the cartridge; and

a locking assembly that permits said driver ( 86 ) to rotate in a first rotational direction and blocks rotation of said driver ( 86 ) in a second rotational direction opposite to the first rotational direction.

2. The combination according to claim 1 , wherein said second shaft ( 88 ) is threadedly received inside a hollow portion of said first shaft ( 84 ).

3. The combination according to claim 1 , wherein said driving plunger ( 82 ) is at a distal end of said first shaft ( 84 ).

4. A combination cartridge and cartridge interface assembly comprising:

a rotationally immobile cartridge ( 22 ) having an inner cylindrical surface, a first stopper ( 24 ) slidingly inserted in the cartridge ( 22 ), a distal end and a substance therein for administration to a subject: and

a cartridge interface assembly ( 80 ) comprising:

a driving plunger ( 82 ) comprising a first shaft ( 84 ), the driving plunger ( 82 ) having an abutting surface and one or more outer surfaces in contact with the inner cylindrical surface of the cartridge ( 22 );

a driver ( 86 ) comprising a second shaft ( 88 ). said second shaft ( 88 ) mating with said first shaft ( 84 ), so that said shafts are movable telescopically with respect to one another, wherein rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance in a direction away from said driver ( 86 ), the arrangement being such that on insertion of the cartridge interface assembly ( 80 ) in the rotationally immobile cartridge ( 22 ), the one or more outer surfaces of the driving plunger ( 82 ) and the inner cylindrical surface of the cartridge ( 22 ) have a frictional relationship such that it is easier for the driving plunger ( 82 ) to move linearly than rotate within the cartridge, wherein the frictional relationship is the only force impeding rotation of the driving plunger ( 82 ) with respect to the cartridge ( 22 ) such that rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance only towards the distal end until the abutting surface of the driving plunger ( 82 ) abuts against the stopper ( 24 ) whereupon the driving plunger ( 82 ) urges the stopper ( 24 ) towards the distal end for metering substance from the cartridge, an intermediate shaft ( 90 ) being threadedly received inside a hollow portion of said first shaft ( 84 ), said second shaft ( 88 ) being threadedly received inside a hollow portion of said intermediate shaft ( 90 ); and

a locking assembly that permits said driver ( 86 ) to rotate in a first rotational direction and blocks rotation of said driver ( 86 ) in a second rotational direction opposite to the first rotational direction.

5. A combination cartridge and cartridge interface assembly comprising:

a rotationally immobile cartridge ( 22 ) having an inner cylindrical surface, a first stopper ( 24 ) slidingly inserted in the cartridge ( 22 ), a distal end and a substance therein for administration to a subject; and

a cartridge interface assembly ( 80 ) comprising:

a driving plunger ( 82 ) comprising a first shaft ( 84 ), the driving plunger ( 82 ) having an abutting surface and one or more outer surfaces in contact with the inner cylindrical surface of the cartridge ( 22 );

a driver ( 86 ) comprising a second shaft ( 88 ), said second shaft ( 88 ) mating with said first shaft ( 84 ), so that said shafts are movable telescopically with respect to one another, wherein rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance in a direction away from said driver ( 86 ), the arrangement being such that on insertion of the cartridge interface assembly ( 80 ) in the rotationally immobile cartridge ( 22 ), the one or more outer surfaces of the driving plunger ( 82 ) and the inner cylindrical surface of the cartridge ( 22 ) have a frictional relationship such that it is easier for the driving plunger ( 82 ) to move linearly than rotate within the cartridge, wherein the frictional relationship is the only force impeding rotation of the driving plunger ( 82 ) with respect to the cartridge ( 22 ) such that rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance only towards the distal end until the abutting surface of the driving plunger ( 82 ) abuts against the stopper ( 24 ) whereupon the driving plunger ( 82 ) urges the stopper ( 24 ) towards the distal end for metering substance from the cartridge, a threaded fastener ( 102 ) protrudes from a distal end of said cartridge interface assembly ( 100 ) that mates with a threaded hole ( 1 26 ) formed in said plunger ( 1 24 ); and

a locking assembly that permits said driver ( 86 ) to rotate in a first rotational direction and blocks rotation of said driver ( 86 ) in a second rotational direction opposite to the first rotational direction.

6. A combination cartridge and cartridge interface assembly comprising:

a rotationally immobile cartridge ( 22 ) having an inner cylindrical surface, a first stopper ( 24 ) slidingly inserted in the cartridge ( 22 ), a distal end and a substance therein for administration to a subject; and

a cartridge interface assembly ( 80 ) comprising:

a driving plunger ( 82 ) comprising a first shaft ( 84 ), the driving plunger ( 82 ) having an abutting surface and one or more outer surfaces in contact with the inner cylindrical surface of the cartridge ( 22 );

a driver ( 86 ) comprising a second shaft ( 88 ), said second shaft ( 88 ) mating with said first shaft ( 84 ), so that said shafts are movable telescopically with respect to one another, wherein rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance in a direction away from said driver ( 86 ), the arrangement being such that on insertion of the cartridge interface assembly ( 80 ) in the rotationally immobile cartridge ( 22 ), the one or more outer surfaces of the driving plunger ( 82 ) and the inner cylindrical surface of the cartridge ( 22 ) have a frictional relationship such that it is easier for the driving plunger ( 82 ) to move linearly than rotate within the cartridge, wherein the frictional relationship is the only force impeding rotation of the driving plunger ( 82 ) with respect to the cartridge ( 22 ) such that rotation of said driver ( 86 ) causes said driving plunger ( 82 ) to linearly advance only towards the distal end until the abutting surface of the driving plunger ( 82 ) abuts against the stopper ( 24 ) whereupon the driving plunger ( 82 ) urges the stopper ( 24 ) towards the distal end for metering substance from the cartridge, said driver ( 86 ) being formed with a recess ( 104 ), bounded by a wall ( 105 ) and a first locking tooth ( 106 ), and a proximal end of a body ( 103 ) of said cartridge interface assembly ( 80 , 100 ) is formed with a second locking tooth ( 108 ), which in a final assembly position, is received in said recess ( 104 ), and wherein said first and second locking teeth ( 106 , 108 ) are formed with slanted walls ( 110 , 112 ) which can glide over each other in the first rotational direction, but said second locking tooth ( 108 ) cannot move past said wall ( 105 ) in the second rotational direction.

7. A cartridge interface assembly ( 100 ), comprising:

a rotatable driver ( 86 ), linkable to a stopper ( 24 ), slidingly disposed in a cartridge ( 22 ) for advancing said stopper ( 24 ) distally in said cartridge for dispensing a substance from said cartridge ( 22 ), wherein a locking assembly permits said driver ( 86 ) to rotate in a first rotational direction and blocks rotation of said driver ( 86 ) in a second rotational direction opposite to the first rotational direction, wherein said driver ( 86 ) is formed with a recess ( 104 ), bounded by a wall ( 105 ) and a first locking tooth ( 106 ), and a proximal end of a body ( 103 ) of said cartridge interface assembly ( 100 ) is formed with a second locking tooth ( 108 ), which in a final assembly position, is received in said recess ( 104 ), and wherein said first and second locking teeth ( 106 , 108 ) are formed with slanted walls ( 110 , 112 ) which can glide over each other in the first rotational direction, but said second locking tooth ( 108 ) cannot move past said wall ( 105 ) in the second rotational direction.