TOPICAL ANTIVIRAL FORMULATIONS
The disclosure provides antiviral pharmaceutical compositions comprising one or more antiviral compounds and 2-deoxy-D-glucose in the form of lip-balms, creams and ointments. A specific embodiment discloses a lip-balm composition comprising acyclovir and 2-deoxy-D-glucose.
1 . A pharmaceutical composition comprising a therapeutically effective amount of an antiviral compound selected from one or more of the group consisting of acyclovir, vidarabine, azidothymidine, ganciclovir, famciclovir, penciclovir, brivudine, cidofovir, trifluridine, foscarnet, and a pharmaceutically acceptable salt or hydrate thereof; and
a therapeutically effective amount of 2-deoxy-D-glucose.
2 . The composition of claim 1 , wherein the antiviral compound is selected from the group consisting of acyclovir, famciclovir, penciclovir, and foscarnet.
3 . The composition of claim 2 wherein the antiviral compound is acyclovir.
4 . The composition of claim 1 in a form selected from a lip-balm, stick, cream or ointment.
5 . The composition of claim 4 in a lip-balm form.
6 . The composition of claim 5 , further comprising one or more polyethylene glycols.
7 . The composition of claim 6 , further comprising one or more sweeteners or flavorings.
8 . The composition of claim 7 wherein the sweetener is stevioside.
9 . The composition of claim 7 wherein the flavoring is spearmint oil.
10 . The composition of claim 3 wherein the composition comprises from about 3 wt % to about 7 wt % of acyclovir and from about 0.1 wt % to about 5 wt % of 2-deoxy-D-glucose.
11 . The composition of claim 10 wherein the composition comprises about 5 wt % of acyclovir and about 0.2 wt % of 2-deoxy-D-glucose.
12 . A method of treating a herpes viral infection of a patient in need thereof comprising administering a pharmaceutical composition comprising a therapeutically effective amount of an antiviral compound selected from the group consisting of acyclovir, vidarabine, azidothymidine, ganciclovir, famciclovir, penciclovir, brivudine, cidofovir, trifluridine, foscarnet, and a pharmaceutically acceptable salt thereof; and a therapeutically effective amount of 2-deoxy-D-glucose.
13 . The method of claim 12 , wherein the antiviral compound is acyclovir.
14 . The method of claim 12 , wherein the composition is in a form selected from a lip-balm, stick, cream or ointment.
15 . The method of claim 14 , wherein the composition is in a lip-balm form.
16 . The method of claim 13 , wherein the composition comprises from about 3 wt % to about 7 wt % of acyclovir and from about 0.1 wt % to about 5 wt % of 2-deoxy-D-glucose.
17 . The method of claim 16 , wherein the topical comprises about 5 wt % of acyclovir and about 0.2 wt % of 2-deoxy-D-glucose.
18 . The method of claim 12 , wherein the treatment is for latent infection of herpes simplex type 1 infection.
19 . The method of claim 12 , wherein the treatment is for latent infection of herpes simplex type 2 infection.
20 . The method of claim 12 , wherein the infection is an orofacial herpes infection.
21 . A method of reducing the duration of a herpes viral infection outbreak in a mammal in need thereof comprising administering a pharmaceutical composition comprising a therapeutically effective amount of an antiviral compound selected from the group consisting of acyclovir, vidarabine, azidothymidine, ganciclovir, famciclovir, penciclovir, brivudine, cidofovir, trifluridine, foscarnet, and a pharmaceutically acceptable salt thereof; and a therapeutically effective amount of 2-deoxy-D-glucose.
22 . The method of claim 21 , wherein the antiviral compound is selected from the group consisting of acyclovir, famciclovir, penciclovir, and foscarnet.
23 . The method of claim 21 , wherein the antiviral compound is acyclovir.
24 . The method of claim 21 wherein the treatment is for latent infection of herpes simplex type 1 infection.
25 . The method of claim 21 , wherein the treatment is for latent infection of herpes simplex type 2 infection.
26 . The method of claim 21 , wherein the infection is an orofacial herpes infection.