IP Library Granted Patent US 8,535,736
Granted Patent B2
US 8,535,736 · App. 13/523,512 · Granted Sep 17, 2013

Methods and compositions for the treatment of infection or infectious colonization of the eyelid, ocular surface, skin or ear

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Quick Facts
Patent No.
US 8,535,736
App. No.
13/523,512
Granted
Sep 17, 2013
Kind
B2
Abstract

The instant invention provides methods and compositions for the treatment of infection or infectious colonization of the eyelid and/or ocular surface for the treatment and prevention of ocular disorders and eyelid disorders.

Claims (13)

1. A method of cleaning skin of a subject in need thereof consisting essentially of topically applying an aqueous gel or foam composition to the skin of said subject consisting essentially of 0.7 wt. % to about 1.5 wt. % linalool, 0.0125 wt. % to about 0.050 wt % tea tree oil and a chelator selected from the group consisting of EDTA, nitrilotriacetate, sodium hexametaphosphate, acetylsalicylate and ascorbate and wherein the aqueous gel or foam composition is bacteriostatic or bactericidal against gram negative bacteria and gram positive bacteria.

2. The method of claim 1 , wherein the linalool is present in a concentration of between about 0.80% and about 1.25% by weight.

3. The method of claim 1 , wherein the concentration of the linalool is about 0.90% by weight.

4. The method of claim 1 , wherein the tea tree oil is present in a concentration of between about 0.02% to about 0.04% by weight.

5. The method of claim 1 , wherein the concentration of the tree tea oil is about 0.025% by weight.

6. The method of claim 1 , wherein the membrane permeablizer is trisodium EDTA.

7. The method of claim 1 wherein the membrane permeablizer is trisodium EDTA and the concentration of the trisodium EDTA is about 0.03% by weight.

8. The method of claim 1 wherein the aqueous gel or foam composition is topically applied to the eyelid.

9. The method of claim 8 wherein the aqueous gel or foam composition membrane has about 0.03% by weight trisodium EDTA.

10. The method of claim 8 , wherein the linalool is present in a concentration of between about 0.80% and about 1.25% by weight.

11. The method of claim 8 , wherein the concentration of the linalool is about 0.90% by weight.

12. The method of claim 8 , wherein the tea tree oil is present in a concentration of between about 0.02% to about 0.04% by weight.

13. The method of claim 8 , wherein the concentration of the tree tea oil is about 0.025% by weight.

Assignments (20)
SECURITY INTEREST Recorded Jul 24, 2026
From: MEDTECH PRODUCTS INC.; INSIGHT PHARMACEUTICALS CORPORATION; DENTEK ORAL CARE, INC.
To: CITIBANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 075392/0725 →
RELEASE OF SECURITY INTEREST IN CERTAIN PATENTS @ REELS AND FRAMES: 053954/0755 AND 053955/0060 Recorded Jul 7, 2023
From: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS ADMINISTRATIVE AGENT
To: AKORN OPERATING COMPANY LLC
Reel/Frame 064234/0872 →
CORRECTION BY DECLARATION TO CORRECT THE 10 ERRONEOUSLY NULLIFIED PROPERTIES ON COVER SHEET AT REEL 057970 FRAME 0475. ASSIGNOR HEREBY CONFIRMS THAT THE 10 PROPERTIES LISTED THERE AND HEREIN SHOULD NOT HAVE BEEN NULLIFIED. Recorded Nov 12, 2021
From: AKORN OPERATING COMPANY LLC
To: MEDTECH PRODUCTS INC.
Reel/Frame 058104/0741 →
CORRECTION BY NULLIFICATION TO CORRECT INCORRECTLY RECORDED PROPERTY NUMBERS AT REEL/FRAME 57222/0489. ASSIGNOR HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 25, 2021
From: AKORN OPERATING COMPANY LLC
To: MEDTECH PRODUCTS INC.
Reel/Frame 057970/0475 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2021
From: AKORN OPERATING COMPANY LLC
To: MEDTECH PRODUCTS INC.
Reel/Frame 057222/0489 →
RELEASE OF SECURITY INTEREST Recorded Jul 8, 2021
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: AKORN, INC.; AKORN INTERMEDIATE COMPANY LLC; AKORN OPERATING COMPANY, LLC
Reel/Frame 056794/0730 →
RELEASE OF SECURITY INTEREST Recorded Jul 8, 2021
From: MIDCAP FUNDING IV TRUST
To: AKORN OPERATING COMPANY, LLC
Reel/Frame 056794/0811 →
RELEASE OF SECURITY INTEREST RECORDED AT 032714/0440 Recorded May 10, 2021
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: ADVANCED VISION RESEARCH, INC.
Reel/Frame 056194/0806 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 052753/0356 Recorded May 3, 2021
From: WILMINGTON SAVINGS FUND SOCIETY, FSB
To: ADVANCED VISION RESEARCH, INC.
Reel/Frame 056122/0720 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 032714/0411 Recorded Mar 29, 2021
From: JPMORGAN CHASE BANK, N.A.
To: ADVANCED VISION RESEARCH, INC.
Reel/Frame 055759/0646 →
CORRECTIVE ASSIGNMENT TO CORRECT THE SCHEDULE OF PATENT APPLICATIONS AND GRANTED PATENTS TO BE ASSIGNED TO AKORN OPERATING COMPANY LLC PREVIOUSLY RECORDED ON REEL 054202 FRAME 0382. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Dec 1, 2020
From: AKORN, INC.; ADVANCED VISION RESEARCH, LLC; HI-TECH PHARMACAL CO., LLC
To: AKORN OPERATING COMPANY, LLC
Reel/Frame 055326/0694 →
ENTITY CONVERSION Recorded Nov 24, 2020
From: ADVANCED VISION RESEARCH, INC.
To: ADVANCED VISION RESEARCH, LLC
Reel/Frame 054513/0338 →
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Nov 5, 2020
From: AKORN OPERATING COMPANY LLC
To: MIDCAP FUNDING IV TRUST
Reel/Frame 054333/0247 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2020
From: AKORN, INC.; ADVANCED VISION RESEARCH, LLC; HI-TECH PHARMACAL CO., LLC
To: AKORN OPERATING COMPANY, LLC
Reel/Frame 054202/0382 →
SECURITY INTEREST Recorded Oct 1, 2020
From: AKORN OPERATING COMPANY LLC
To: WILMINGTON SAVINGS FUND SOCIETY, FSB
Reel/Frame 053954/0755 →
SECURITY INTEREST Recorded Oct 1, 2020
From: AKORN OPERATING COMPANY LLC
To: WILMINGTON SAVINGS FUND SOCIETY, FSB
Reel/Frame 053955/0060 →
SECURITY INTEREST Recorded May 26, 2020
From: ADVANCED VISION RESEARCH, INC.
To: WILMINGTON SAVINGS FUND SOCIETY, FSB
Reel/Frame 052753/0356 →
SECURITY INTEREST Recorded Apr 1, 2020
From: JPMORGAN CHASE BANK, N.A., AS RESIGNING ADMINISTRATIVE AGENT
To: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS SUCCESSOR ADMINISTRATIVE AGENT
Reel/Frame 052284/0618 →
SECURITY INTEREST (ABL) Recorded Apr 18, 2014
From: ADVANCED VISION RESEARCH, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 032714/0411 →
SECURITY INTEREST (TERM LOAN) Recorded Apr 18, 2014
From: ADVANCED VISION RESEARCH, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 032714/0440 →