IP Library › Granted Patent US 8,536,150
Granted Patent B2
US 8,536,150 · App. 13/525,223 · Granted Sep 17, 2013

Methods of myocardial perfusion imaging

Inventors: Luiz Belardinelli (Palo Alto, CA); Brent K. Blackburn (Los Altos, CA); Zhenhai Gao (San Jose, CA)
Assignee: Gilead Sciences, Inc.
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Quick Facts
Patent No.
US 8,536,150
App. No.
13/525,223
Granted
Sep 17, 2013
Kind
B2
Abstract

The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.

Claims (3)

1. A method of myocardial perfusion imaging in a human in need thereof comprising: administering to the human (a) CVT-3146, also known as (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide, in an amount of 0.2 to 9 μg/kg by a single intravenous bolus dose of a liquid pharmaceutical composition comprising CVT-3146 and (b) a radionuclide, and thereafter determining areas of insufficient blood flow.

2. The method of claim 1 , wherein the amount of CVT-3146 administered is 1 to 9 μg/kg.

3. The method of claim 1 , wherein the pharmaceutical composition is administered before the radionuclide is administered.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2013
From: BELARDINELLI, LUIZ; BLACKBURN, BRENT K.; GAO, ZHENHAI
To: CV THERAPEUTICS, INC.
Reel/Frame 031353/0353 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2013
From: APEX MERGER SUB, INC.; CV THERAPEUTICS, INC.
To: GILEAD PALO ALTO, INC.
Reel/Frame 031353/0358 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2013
From: GILEAD PALO ALTO, INC.
To: GILEAD SCIENCES, INC.
Reel/Frame 031353/0873 →
Continuity (8)
Continuation 13286069 · Oct 31, 2011
Continuation 12435176 · May 4, 2009
Continuation 11070768 · Mar 2, 2005
Continuation 10614702 · Jul 3, 2003
Continuation 09792617 · Feb 23, 2001
Provisional Application 60184296 · Feb 23, 2000
Provisional Application 60219876 · Jul 21, 2000
Related Publication 20120251440A1 · Oct 4, 2012