Method for lowering cholesterol
The present invention relates to a method of lowering cholesterol in a patient in need thereof by administering to said patient a therapeutic effective amount of a compound selected from the group of Dihydroxyacetone phosphate (DHAP); 1-acyl-DHAP; 1-alkyl-DHAP; 1-alkyl-glyceraldehyde-3-phosphate (G3P); 1-alkyl, 2-acyl-G3P; 1-alkyl, 2-acyl-glycerol; 1-alkyl,2-acyl-glycerylphosphatidylethanolamine (GPE), 1-alkyl, diacyl glycerol (sn-1=16:0, sn-2=docosohexaenoic acid (DHA); sn-3=DHA) (sn-1 position has an alkyl ether bond, sn-2 and sn-3 positions have acyl bonds); 1-alkyl diacyl glycerol (sn-1=16:0, sn-2=18:1, sn-3=18:1) (sn-1 position has an alkyl ether bond, sn-2 and sn-3 positions have acyl bonds); triacyl glycerol (sn-1=16:0, sn-2=DHA, sn-3=DHA) (all three positions have acyl bonds); and triacyl glycerol (sn-1=16:0, sn-2=18:1, sn-3=18:1) (all three positions have acyl bonds) and pharmaceutically acceptable salts thereof.
1. A method of lowering cholesterol in a patient in need thereof by administering to said patient a therapeutic effective amount of a 1-alkyl, 2-acyl-glycerol wherein the side chains are:
16:0, 18:0, 18:1, 18:2, or 18:3 as alkyl at the sn-1 position, and
18:1, 18:2, 18:3, 20:4, 20:5, 20:6, 22:4, 22:5, 22:6, 24:4, 24:5, or 24:6 as acyl at the sn-2 position,
or pharmaceutically acceptable salts thereof.
2. The method of claim 1 wherein the side chains are:
16:0 or 18:0 as alkyl at the sn-1 position, and
22:6 as acyl at the sn-2 position.
3. A method of lowering cholesterol in a patient in need thereof by administering to said patient a therapeutically effective amount of a 1-alkyl, 2-acyl-glycerol of the formula:
or a pharmaceutically acceptable salt thereof.