IP Library Granted Patent US 11,047,791
Granted Patent B2
US 11,047,791 · App. 13/526,223 · Granted Jun 29, 2021

Systems and methods for sample display and review

Inventors: David Zahniser (Wellesley, MA); Michael Zahniser (Jamaica Plain, MA); Adam Yie (Wellesley, MA)
Assignee: Roche Diagnostics Hematology, Inc.
G01N15/1475G06T7/0012G06T7/136G01N15/1429G01N2015/0073G01N2015/1465G01N2015/1472G01N2035/0091G06T2207/10056G06T2207/30024
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,047,791
App. No.
13/526,223
Granted
Jun 29, 2021
Kind
B2
Abstract

Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells.

Claims (32)

1. A method of displaying images of cells in a sample, the method comprising:

obtaining a first set of images of a plurality of cells in the sample;

determining values of a property for each one of the cells based on the first set of images; and

displaying a second set of cell images in an ordered array on a display device,

wherein each member of the second set of cell images corresponds to one of the plurality of cells and is displayed as a user-selectable control on the display device;

wherein each member of the second set of cell images is ordered in the array based on the value of the property determined for the cell that corresponds to the member; and

wherein, when one of the user-selectable controls is selected, the method further comprises displaying a third image on the display device, the third image having a field of view that is different from the member of the second set of cell images corresponding to the selected control, and the third image showing the cell associated with the selected control and one or more neighboring cells in the sample.

2. The method of claim 1 , wherein the sample comprises blood and the cells comprise red blood cells.

3. The method of claim 1 , wherein the sample comprises blood and the cells comprise platelets.

4. The method of claim 1 , wherein the property comprises a cell hemoglobin content of each of the cells.

5. The method of claim 1 , wherein the property comprises a cell volume of each of the cells.

6. The method of claim 1 , wherein the property comprises a cell size of each of the cells.

7. The method of claim 1 , wherein the property comprises an optical density of each of the cells.

8. The method of claim 1 , wherein the property comprises a shape of each of the cells.

9. A system for visual inspection of cells, the system comprising:

a light source configured to illuminate a sample;

a detector configured to obtain a first set of images of a plurality of cells in the sample;

a display device configured to display images of cells; and

an electronic processor connected to the detector and the display device, and configured to:

determine values of a property for each one of the cells based on the first set of images; and

display a second set of cell images in an ordered array on the display device,

wherein each member of the second set of cell images corresponds to one of the plurality of cells and is displayed as a user-selectable control on the display device;

wherein each member of the second set of cell images is ordered in the array based on the value of the property determined for the cell that corresponds to the member; and

wherein the electronic processor is configured so that when one of the user-selectable controls is selected, the electronic processor displays a third image on the display device, the third image having a field of view that is different from the member of the second set of cell images corresponding to the selected control, and the third image showing the cell associated with the selected control and one or more neighboring cells in the sample.

10. The system of claim 9 , wherein the property comprises a cell hemoglobin content of each of the cells.

11. The system of claim 9 , wherein the property comprises a cell volume of each of the cells.

12. The system of claim 9 , wherein the property comprises a member selected from the group consisting of a cell size of each of the cells, an optical density of each of the cells, and a shape of each of the cells.

13. The system of claim 9 , wherein the electronic processor is further configured to analyze the first set of images to identify inclusions in the cells, and wherein the property is a property related to the inclusions and comprises a size of the inclusions, a shape of the inclusions, or a number of the inclusions.

14. The method of claim 1 , wherein each member of the second set of cell images corresponds to and shows only one of the plurality of cells.

15. The method of claim 1 , wherein the sample comprises blood and the cells comprise white blood cells.

16. The method of claim 1 , wherein the third image overlays at least a portion of the second set of cell images on the display device.

17. The method of claim 1 , wherein the third image comprises a classification control configured to allow selection of a classification for the cell associated with the selected control, the method further comprising, when the classification control is selected, assigning the selected classification to the cell.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2014
From: CONSTITUTION MEDICAL, INC.
To: ROCHE DIAGNOSTICS HEMATOLOGY, INC.
Reel/Frame 031972/0675 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2012
From: ZAHNISER, DAVID; ZAHNISER, MICHAEL; YIE, ADAM
To: CONSTITUTION MEDICAL, INC.
Reel/Frame 029007/0674 →
Continuity (5)
Provisional Application 61498456 · Jun 17, 2011
Provisional Application 61510614 · Jul 22, 2011
Provisional Application 61510696 · Jul 22, 2011
Provisional Application 61510710 · Jul 22, 2011
Related Publication 20130002847A1 · Jan 3, 2013