Solvent/polymer solutions as suspension vehicles
View Patent ↗A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
1. A stable, nonaqueous suspension formulation, comprising:
a particle formulation comprising an active agent and an excipient, wherein the active agent comprises a peptide, polypeptide, or protein, and the excipient comprises methionine; and
a nonaqueous, single-phase vehicle consisting essentially of about 10% to about 90% (w/w) polyvinylpyrrolidone and about 90% to about 10% (w/w) benzyl benzoate, wherein the vehicle has a viscosity of between approximately 10,000 poise to approximately 20,000 poise measured at 37° C.
2. The suspension formulation of claim 1 , wherein the particle formulation comprises one or more additional excipients.
3. The suspension formulation of claim 2 , wherein the one or more additional excipients are selected from the group consisting of citrate buffer, sucrose, succinate, and dextran.
4. The suspension formulation of claim 2 , wherein the one or more additional excipients comprise sucrose and citrate buffer.
5. The suspension formulation of claim 1 , wherein the single-phase vehicle consists essentially of about 25% to about 75% (w/w) polyvinylpyrrolidone and about 75% to about 25% (w/w) benzyl benzoate.
6. The suspension formulation of claim 1 , wherein the particle formulation is formed by lyophilization, spray-drying, or freeze-drying.
7. The suspension formulation of claim 1 , wherein the particle formulation is present in the suspension formulation in a range from approximately 0.1 to 50 wt %.
8. The suspension formulation of claim 1 , wherein the particle formulation is present in the suspension formulation in a range from approximately 3 to 12 wt %.
9. A method of making the suspension formulation of claim 1 , the method comprising
blending the polyvinylpyrrolidone and benzyl benzoate to form the single-phase vehicle, wherein a vacuum is applied during blending to remove air bubbles; and
adding the particle formulation to form the suspension formulation.
10. The method of claim 9 , wherein the vacuum is between about −5 to about −10 Hg.
11. The method of claim 10 , further comprising increasing the vacuum after the polyvinylpyrrolidone is incorporated into the benzyl benzoate to about −30 Hg.