Method for treating pathologies associated with hypoxia using MIF inhibitors
View Patent ↗Methods are provided for treating pathologies associated with hypoxia with an MIF inhibitor. Methods are also provided for treating a subject having, or at risk for pulmonary hypertension, with an MIF inhibitor. Methods are also provided for treating a subject having, or at risk from, a CNS disorder associated with hypoxia, with an MIF inhibitor. Methods are also provided of treating severe chronic lung disease, hypoxia-induced right ventricular hypertrophy or hypoxia-induced pulmonary vascular remodeling with an MIF inhibitor. Methods of diagnosing a subject with pulmonary hypertension are also provided.
1. A method for treating a disorder associated with hypoxia in a subject comprising administering to the subject an amount of a small molecule macrophage migration inhibitory factor (MIF) inhibitor effective to treat pulmonary hypertension associated with hypoxia.
2. The method of claim 1 , wherein the disorder is hypoxia-induced pulmonary hypertension.
3. The method of claim 1 , wherein the subject has chronic obstructive pulmonary disease or has interstitial lung disease.
4. The method of claim 3 , wherein the subject has chronic obstructive pulmonary disease.
5. The method of claim 3 , wherein the subject has interstitial lung disease.
6. The method of claim 1 , wherein the subject has previously been diagnosed as having pulmonary hypertension.
7. The method of claim 1 , wherein the subject has hypoxia-induced right ventricular hypertrophy.
8. The method of claim 1 , wherein the subject has hypoxia-induced pulmonary vascular remodeling.
9. The method of claim 1 , wherein the MIF inhibitor is administered inhalationally.
10. The method of claim 1 , wherein the small molecule MIF inhibitor has the structure:
11. A method for treating hypoxia-induced right ventricular hypertrophy or hypoxia-induced pulmonary vascular remodeling in a subject comprising administering to the subject an amount of a small molecule macrophage migration inhibitory factor (MIF) inhibitor effective to treat hypoxia-induced right ventricular hypertrophy or effective to treat hypoxia-induced pulmonary vascular remodeling.