Method of modulating stress-activated protein kinase system
View Patent ↗Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.
1. A compound having the structure of Genus Ia:
wherein
R 2 is selected from the group consisting of phenyl and substituted phenyl;
R 1 , R 3 , and R 4 are H; and
X 1 , X 2 , X 3 , X 4 , and X 5 are independently selected from the group consisting of H, halogen, C 1 -C 10 alkoxy, and hydroxy.
2. The compound of claim 1 , wherein R 2 is substituted phenyl.
3. The compound of claim 2 , wherein R 2 is phenyl substituted with halogen.
4. The compound of claim 3 , wherein R 2 is phenyl substituted with fluorine.
5. The compound of claim 1 , wherein X 1 , X 2 , X 3 , X 4 , and X 5 are independently selected from the group consisting of H and halogen.