Cleanser compositions and methods for using the same
View Patent ↗The present invention is directed to anti-microbial cleanser compositions comprising linalool, hinokitiol and dipropylene glycol. The present invention further provides methods for using these compositions to maintain eyelid hygiene, to treat an ocular disorder or to clean a skin surface. The cleanser compositions of the present invention can be in the form of a foam, gel or liquid.
1. A method of cleansing the eyelid or the skin surrounding the eyelid of a subject consisting essentially of applying to the eyelid or the skin surrounding the eyelid of the subject a cleanser composition consisting essentially of 0.5-2% by weight linalool in the total composition, 0.01-5% by weight hinokitiol in the total composition and 1-50% by weight in the total composition of a compound selected from the group consisting of propylene glycol, ethylene glycol and dipropylene glycol in the total composition.
2. The method of claim 1 , wherein the cleanser composition is applied as a foam, gel or liquid.
3. The method of claim 1 wherein the body surface is cleaned to treat an ocular disorder.
4. The method of claim 3 , wherein the ocular disorder is selected from the group consisting of dry eye, excessive bacteria on the eyelid dermis, Meibomian gland dysfunction, blepharitis, acne rosacea, scalp dandruff, seborrheic dermatitis, chalazion, hordeolum, sty infectious conjunctivitis, corneal ulcer, demodex infestation, and any combination thereof.
5. The method of claim 4 , wherein the ocular disorder is anterior or posterior blepharatis.
6. The method of claim 1 , wherein the composition is effective against at least one of the following microorganisms: Staphylococcus aureus, Pseudomonas aeruginosa, Branhamella catarrhalis, Escherichia coli, Serratia marcescens, Staphylococcus epidermidis , and Pityrosporum ovale.
7. The method of claim 6 , wherein the Staphylococcus aureus is methicillin resistant Staphylococcus aureus.
8. A method of cleansing the eyelid or the skin surrounding the eyelid of a subject consisting essentially of applying to the eyelid or the skin surrounding the eyelid of the subject an aqueous cleanser composition consisting essentially of the following components in approximately the following concentrations as a percent by weight in the total composition:
(a) a blend of PEG-80, sorbitan laurate,
0.5-10.0%;
sodium trideceth sulfate, cocamidopropyl
betaine, sodium lauroamphoacetate,
PEG-150 distearate, and sodium
laureth-13 carboxylate
(b) Decyl Glucoside
0.2-10.0%;
(c) Linalool
0.5-2.0%;
(d) Cocamidopropyl PG-Dimonium
0.01-5.0%;
Chloride Phosphate
(e) Trisodium EDTA
0.01-1.0%;
(f) Allantoin
0.01-1.0%;
(g) Panthenol
0.01-1.0%;
(h) Hinokitiol
0.01-5.0%;
(i) Tea Tree Oil
0.005-2.0%;
(j) Vitamin E Acetate
0.005-2.0%;
(k) Water
0.0-98.15%;
(l) Dipropylene glycol
1.0-50.0%; and
(m) Cocamidopropyl betaine
0.1-20.0%.
9. A method of cleansing the eyelid or the skin surrounding the eyelid of a subject consisting essentially of applying to the eyelid or the skin surrounding the eyelid of the subject an aqueous cleanser composition consisting essentially of the following components in approximately the following amounts as a percent by weight in the total composition:
(a) a blend of PEG-80, sorbitan laurate, sodium trideceth sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, PEG-150 distearate, and sodium laureth-13 carboxylate 3.8%;
(b) Decyl Glucoside
1.7%
(c) Linalool
0.9%;
(d) Cocamidopropyl PG-
0.2%;
Dimonium Chloride Phosphate
(e) Trisodium EDTA
0.1%;
(f) Allantoin
0.1%;
(g) Panthenol
0.1%
(h) Hinokitiol
0.05%;
(i) Tea Tree Oil
0.025%;
(j) Vitamin E Acetate
0.01%;
(k) Water
68.215%;
(l) Dipropylene glycol
23.0%; and
(m) Cocamidopropyl betaine
2.0%.
10. The method of claim 1 , wherein the pH range of the cleanser composition is about 4.5-6.0.
11. The method of claim 1 , wherein the pH range of the cleanser composition is about 5.3-5.7.
12. A method of cleansing the eyelid or the skin surrounding the eyelid of a subject consisting essentially of applying to the eyelid or the skin surrounding the eyelid of the subject an aqueous cleanser composition consisting essentially of 0.5-2% by weight linalool in the total composition, 0.01-5% by weight hinokitiol in the total composition, 1-50% by weight in the total composition of a compound selected from the group consisting of propylene glycol, ethylene glycol and dipropylene glycol in the total composition, and cocamidopropyl PG-dimonium chloride phosphate.
13. The method of claim 1 , wherein the composition is in the form of a foam.
14. The method of claim 1 , wherein the cleanser composition is formulated such that upon application to the body surface of the subject the cleanser composition does not substantially damage or irritate the body surface.
15. A method of cleansing the eyelid or the skin surrounding the eyelid of a subject consisting essentially of applying to the eyelid or the skin surrounding the eyelid of the subject an aqueous cleanser composition consisting essentially of 0.5-2% linalool in the total composition, 0.01-5% by weight hinokitiol in the total composition, 1-50% by weight in the total composition of a compound selected from the group consisting of propylene glycol, ethylene glycol and dipropylene glycol in the total composition, and between about 0.1% and about 20% by weight cocamidopropyl betaine in the total composition.
16. The method of claim 15 wherein the concentration of cocamidopropyl betaine is between about 0.5% and about 10% by weight in the total composition.
17. The method of claim 15 wherein the concentration of cocamidopropyl betaine is about 2% by weight in the total composition.
18. The method of claim 15 wherein the cleanser composition is applied as a foam.
19. The method of claim 15 wherein the pH range of the cleanser composition is about 4.5-6.0.
20. The method of claim 15 wherein the pH range of the cleanser composition is about 5.3-5.7.