Method of improving electrode tissue interface
A critical element of a retinal prosthesis is the stimulating electrode array, which is placed in close proximity to the retina. It is via this interface that a retinal prosthesis electrically stimulates nerve cells to produce the perception of light. The impedance load seen by the current driver consists of the tissue resistance and the complex electrode impedance. The results show that the tissue resistance of the retina is significantly greater than that of the vitreous humor in the eye. Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance.
1. An implantable system for measuring tissue impedance comprising: at least one electrode suitable to be implanted in the vicinity of retinal tissue; an electrical signal generator generating a first electrical signal at a first frequency, followed by a second electrical signal at a second frequency, different from said first frequency, both between 100 Hz and 10,000 Hz; a meter measuring impedance of the retinal tissue after said first and a said second electrical signals; and a processor controlling said electrical signal generator and said meter, wherein the processor is adapted to control said generating and said measuring.
2. The system for measuring tissue impedance according to claim 1 , further comprising means for attaching the at least one electrode to tissue.
3. The system for measuring tissue impedance according to claim 1 , wherein the electrical signal generator generates a series of signals between 500 Hz and 5,000 Hz.
4. The system for measuring tissue impedance according to claim 1 , further comprising a plurality of electrodes with an electrode spacing from 1 mm to 5 mm.
5. The system for measuring tissue impedance according to claim 4 where the electrode spacing is 2 mm-3 mm.
6. The system for measuring tissue impedance according to claim 4 , wherein the electrode spacing is 2.2 mm to 2.5 mm.
7. The system for measuring tissue impedance according to claim 1 , wherein the diameter of the at least one electrode is from 10 μm to 250μm.
8. The system for measuring tissue impedance according to claim 1 , wherein the diameter of the at least one electrode is from 40 μm to 250 μm.
9. The system for measuring tissue impedance according to claim 4 , wherein the electrode spacing is between 600 μm and 1000 μm center to center in the horizontal and vertical direction.
10. The system for measuring tissue impedance according to claim 1 , wherein series resistance ranges from 1 kilo ohm to 80 kilo ohms.
11. The system for measuring tissue impedance according to claim 1 , wherein a magnitude of a constant phase element ranges from 20 nano siemens to 400 nano siemens.
12. The system for measuring tissue impedance according to claim 1 , further comprising adjusting at least one of amplitude and duration of a full set or subset of one or more pulses based on said impedance measurement.
13. The system for measuring tissue impedance according to claim 1 , wherein the frequency range is from 10 Hz to 100 kHz.
14. The system for measuring tissue impedance according to claim 1 , further comprising modeling the electrode tissue interface using a circuit model, the circuit model comprising a series resistance and a polarization impedance, wherein:
values of each of the series resistance and the polarization impedance is based on the impedance measurement, and
the series resistance is a function of the location of the at least one electrode and the polarization impedance is a function of surface quality of each electrode in the at least one electrode.
15. The system for measuring tissue impedance according to claim 1 , further comprising modeling the electrode tissue interface using a circuit model, wherein:
the circuit model comprises a series resistance and a constant phase element in series, and
magnitude and phase of each of the series resistance and the constant phase element is a function of the impedance measurement.
16. An implantable system for measuring tissue impedance comprising:
at least one electrode suitable to be implanted in the vicinity of retinal tissue;
an electrical signal generator generating a first electrical signal at a first frequency, followed by a second electrical signal at a second frequency, different from said first frequency, both between 100 Hz and 10,000 Hz.; a meter measuring impedance of the retinal tissue after said first and said second electrical signals; a memory for storing impedance values; and means for altering further electrical stimulation based on the stored impedance values.
17. The system for measuring tissue impedance according to claim 16 , further comprising means for attaching the at least one electrode to tissue.
18. The system for measuring tissue impedance according to claim 16 , wherein the signal generator generates a series of signals between 500 Hz and 5,000 Hz.
19. The system for measuring tissue impedance according to claim 16 , further comprising a plurality of electrodes with an electrode spacing from 1 mm to 5 mm.
20. The system for measuring tissue impedance according to claim 19 , where the electrode spacing is 2 mm-3 mm.