Pressure support ventilation of patients
View Patent ↗A methodology and apparatus for determining ventilator settings including an end expiratory pressure setting, pressure swing, resistive unloading and target ventilation for delivering ventilatory support based upon generalized patient ventilation characteristics and/or disease classifications. An apparatus may be programmed with the instructions to accomplish the methodology interactively by prompting the user/physician during setup and calculating settings based upon measurements or input responses. Pre-assigned values associated with ventilation characteristics or disease classifications may be combined with a base pressure value or measured values to provide patient customized settings or adjustments to determine pressure levels for the delivery of ventilatory support.
1. An automated method for determining a target ventilation setting of a ventilator, the method comprising:
measuring a patient's partial pressure of CO 2 and ventilation during a partially-assisted awake acclimatization respiratory session,
determining whether the patient's partial pressure of CO 2 is adequate; and
when the patient's measured partial pressure of CO 2 is adequate, automatically calculating a target ventilation based on the measured ventilation,
the calculated target ventilation is adjusted based on different functions depending on whether the patient's measured partial pressure of CO 2 is determined to be above or below a predetermined threshold, the calculated target ventilation is adjusted by multiplying (a) the calculated target ventilation by (b) a function that includes a product of (1) a difference between a measure of the patient's partial pressure of CO 2 and a partial pressure threshold value and (2) a percentage value;
adjusting the ventilator target ventilation setting to the adjusted target ventilation, and
delivering servo controlled ventilator support to the patient according to the adjusted target ventilation setting,
wherein the percentage value differs depending on whether the patient's partial pressure of CO 2 is greater than or less than the predetermined threshold.
2. The method of claim 1 , wherein when the patient's measured partial pressure of CO 2 is inadequate, setting the target ventilation from empirical data.
3. The method of claim 2 , wherein when the patient's measured partial pressure of CO 2 is unacceptable, setting the target ventilation at 70 ml/Kg/min.
4. The method of claim 2 , wherein the target ventilation is further adjusted according to blood gases.
5. The method of claim 4 , wherein the target ventilation is set at 90% of a median ventilation of the session.
6. The method of claim 4 , further comprising setting a backup rate to a median respiratory rate during the awake acclimatization respiratory session.
7. The method of claim 4 , further comprising manually making additional adjustments to the target ventilation based on the partial pressure of CO 2 .
8. The method of claim 1 , wherein when the patient's measured partial pressure of CO 2 is adequate, further measuring the patient's spontaneous ventilation during the partially assisted awake acclimatization respiratory session and setting the target ventilation based on the session.
9. The method of claim 8 , wherein the awake acclimatization respiratory session extends for 60 minutes and the target ventilation is set at 90% of a median ventilation of a final 40 minutes of the session.
10. The method of claim 1 , wherein the calculated target ventilation is adjusted from an absolute value of the difference.
11. The method of claim 1 , wherein the percentage value is 1%.
12. The method of claim 1 , wherein the percentage value is 0.5%.
13. The method of claim 1 , wherein, when the patient's measured partial pressure of CO 2 is equal to a partial pressure threshold value, the target ventilation is calculated without the patient's partial pressure of CO 2 .
14. The method of claim 1 , wherein further comprising receiving input comprising the patient's general ventilation related characteristics and determining, from the general ventilation related characteristics, adjustable settings for unloading the patent's awake ventilatory work.
15. An apparatus for automatically determining a target ventilation setting of a ventilator, the apparatus comprising:
a servo-controlled blower for providing controlled pressurized air to a patient;
a transducer operable to generate a flow signal representative of patient airflow;
a blood gas monitor to generate a PCO 2 signal representative of a measure of patient partial pressure of CO 2 ; and
a processor configured using instructions stored in a memory to
(a) measure a patient's partial pressure of CO 2 and ventilation during a partially-assisted awake acclimatization respiratory session,
(b) access data from the flow signal and the PCO 2 signal, and
(c) when the patient's measure of partial pressure of CO 2 is adequate, automatically calculate a target ventilation based on the ventilation measure form the partially-assisted awake acclimatization respiratory session,
the target ventilation being calculated based on different functions depending on whether the patient's measure of partial pressure of CO 2 is determined to be above or below a predetermined threshold,
the calculated target ventilation is adjusted by multiplying (a) the calculated target ventilation by (b) a function that includes a product of (1) a difference between a measure of the patient's partial pressure of CO 2 and a partial pressure threshold value and (2) a percentage value;
adjusting the ventilator target ventilation setting to the adjusted target ventilation,
wherein the percentage value differs depending on whether the patient's partial pressure of CO 2 is greater than or less than the predetermined threshold.
16. The apparatus of claim 15 , wherein the target ventilation is set at 70 ml/Kg/min when the patient's measure of partial pressure of CO 2 is inadequate.
17. The apparatus of claim 15 , wherein the processor is further operable to adjust the target ventilation based on measurements by the blood gas monitor.
18. The apparatus of claim 15 , wherein the processor is operable to automatically set the target ventilation based on a patient's spontaneous ventilation during the partially-assisted awake acclimatization respiratory session when the processor determines that the patient's partial pressure of CO 2 is adequate.
19. The apparatus of claim 18 , wherein the target ventilation is set at 90% of a median ventilation of the session.
20. The apparatus of claim 19 , wherein the awake acclimatization respiratory session extends for 60 minutes and the target ventilation is set at 90% of a median ventilation of a final 40 minutes of the session.
21. The apparatus of claim 18 , wherein the processor is further configured to set a backup rate to a median respiratory rate based on the awake acclimatization respiratory session.
22. The apparatus of claim 18 , wherein the processor is configured to receive additional adjustments to the target ventilation from a user.
23. The apparatus of claim 15 , wherein the calculated target ventilation is adjusted from an absolute value of the difference.
24. The apparatus of claim 15 , wherein the percentage value differs depending on whether the patent's partial pressure of CO 2 is greater or less than the partial pressure predetermined threshold value.
25. The apparatus of claim 24 , wherein the percentage value is 1%.
26. The apparatus of claim 24 , wherein the percentage value is 0.5%.
27. The apparatus of claim 15 , wherein, when the patient's measure of partial pressure of CO 2 is equal to a partial pressure threshold value, the target ventilation is calculated without the patient's partial pressure of CO 2 .
28. The apparatus of claim 15 , wherein the processor is configured to control the servo-controlled blower in accordance with adjustable settings for unloading awake ventilatory work of the patient calculated from input general ventilation related characteristics of the patient.